DEPENDENCE OF OUTCOMES OF HYPERTROPHIC SCARS LASER TREATMENT ON THE INITIAL REACTIVITY

The purpose of the study was to identify the relationship between the initial state of the organism and the result of the treatment of hypertrophic scars. 38 women of 16-35years of age were examined on the 5-7th days of the menstrual cycle, 16 of them had normotrophic scars and 22 - hypertrophic sca...

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Autores principales:	M. V. Kobets, L. S. Vasilyeva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	treatment of hypertrophic scars reactivity pathogenesis of hypertrophic scars Science Q
Acceso en línea:	https://doaj.org/article/fc08567495924a36bc1a61d9247e739b
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spelling	oai:doaj.org-article:fc08567495924a36bc1a61d9247e739b2021-11-23T06:14:36ZDEPENDENCE OF OUTCOMES OF HYPERTROPHIC SCARS LASER TREATMENT ON THE INITIAL REACTIVITY2541-94202587-959610.12737/23736https://doaj.org/article/fc08567495924a36bc1a61d9247e739b2016-11-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/321https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The purpose of the study was to identify the relationship between the initial state of the organism and the result of the treatment of hypertrophic scars. 38 women of 16-35years of age were examined on the 5-7th days of the menstrual cycle, 16 of them had normotrophic scars and 22 - hypertrophic scars. The quality of scars, lipid profile, the concentration of thyrotropin, free fraction of thyroxine, growth hormone (GH), luteinizing and follicle stimulating hormone (FSH), cortisol, prolactin, estradiol, testosterone, progesterone, the concentration of TNF-a, lL-4, lL-6, lL-10, and the level of autoantibodies to DNA, lFN-a, lFN-y, b2-glycoprotein, Fc-fragments, collagen-2 were determined. Further on the laser treatment was performed: the scar surface was treated by multiple perforations under local anesthesia. Treatment outcome was assessed in 3 months by the clinical characteristics of the scar. lt was found that in 10 women hypertrophic scars reformed in normotrophic scars after the treatment, and 12 women still had hypertrophic scars. Patients with a positive result of treatment had a low concentration of GH (0.5 ± 0.1) and high concentrations of progesterone (6.0 ± 0.4) and FSH (6.7 ± 0.5 in the follicular phase of the cycle). The negative result of the treatment obtained in patients with significant shifts reactivity indicators: high atherogenic index (2.6 ± 0.2) and the level of GH (2.1 ± 0.5), low levels of cortisol (346.8 ± 39), testosterone (1.5 ± 0.2), lL-10 (3.89 ± 1.6) and antibodies to lFN-y (0.206 ± 0.05), lFN-a (0.385 ± 0.02), Fc-fragments (0.317± 0.04).M. V. KobetsL. S. VasilyevaScientific Сentre for Family Health and Human Reproduction Problemsarticletreatment of hypertrophic scarsreactivitypathogenesis of hypertrophic scarsScienceQRUActa Biomedica Scientifica, Vol 1, Iss 6, Pp 60-65 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	treatment of hypertrophic scars reactivity pathogenesis of hypertrophic scars Science Q
spellingShingle	treatment of hypertrophic scars reactivity pathogenesis of hypertrophic scars Science Q M. V. Kobets L. S. Vasilyeva DEPENDENCE OF OUTCOMES OF HYPERTROPHIC SCARS LASER TREATMENT ON THE INITIAL REACTIVITY
description	The purpose of the study was to identify the relationship between the initial state of the organism and the result of the treatment of hypertrophic scars. 38 women of 16-35years of age were examined on the 5-7th days of the menstrual cycle, 16 of them had normotrophic scars and 22 - hypertrophic scars. The quality of scars, lipid profile, the concentration of thyrotropin, free fraction of thyroxine, growth hormone (GH), luteinizing and follicle stimulating hormone (FSH), cortisol, prolactin, estradiol, testosterone, progesterone, the concentration of TNF-a, lL-4, lL-6, lL-10, and the level of autoantibodies to DNA, lFN-a, lFN-y, b2-glycoprotein, Fc-fragments, collagen-2 were determined. Further on the laser treatment was performed: the scar surface was treated by multiple perforations under local anesthesia. Treatment outcome was assessed in 3 months by the clinical characteristics of the scar. lt was found that in 10 women hypertrophic scars reformed in normotrophic scars after the treatment, and 12 women still had hypertrophic scars. Patients with a positive result of treatment had a low concentration of GH (0.5 ± 0.1) and high concentrations of progesterone (6.0 ± 0.4) and FSH (6.7 ± 0.5 in the follicular phase of the cycle). The negative result of the treatment obtained in patients with significant shifts reactivity indicators: high atherogenic index (2.6 ± 0.2) and the level of GH (2.1 ± 0.5), low levels of cortisol (346.8 ± 39), testosterone (1.5 ± 0.2), lL-10 (3.89 ± 1.6) and antibodies to lFN-y (0.206 ± 0.05), lFN-a (0.385 ± 0.02), Fc-fragments (0.317± 0.04).
format	article
author	M. V. Kobets L. S. Vasilyeva
author_facet	M. V. Kobets L. S. Vasilyeva
author_sort	M. V. Kobets
title	DEPENDENCE OF OUTCOMES OF HYPERTROPHIC SCARS LASER TREATMENT ON THE INITIAL REACTIVITY
title_short	DEPENDENCE OF OUTCOMES OF HYPERTROPHIC SCARS LASER TREATMENT ON THE INITIAL REACTIVITY
title_full	DEPENDENCE OF OUTCOMES OF HYPERTROPHIC SCARS LASER TREATMENT ON THE INITIAL REACTIVITY
title_fullStr	DEPENDENCE OF OUTCOMES OF HYPERTROPHIC SCARS LASER TREATMENT ON THE INITIAL REACTIVITY
title_full_unstemmed	DEPENDENCE OF OUTCOMES OF HYPERTROPHIC SCARS LASER TREATMENT ON THE INITIAL REACTIVITY
title_sort	dependence of outcomes of hypertrophic scars laser treatment on the initial reactivity
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/fc08567495924a36bc1a61d9247e739b
work_keys_str_mv	AT mvkobets dependenceofoutcomesofhypertrophicscarslasertreatmentontheinitialreactivity AT lsvasilyeva dependenceofoutcomesofhypertrophicscarslasertreatmentontheinitialreactivity
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DEPENDENCE OF OUTCOMES OF HYPERTROPHIC SCARS LASER TREATMENT ON THE INITIAL REACTIVITY

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