Serum Carnitine Levels in Preterm Infants with Respiratory Distress Syndrome

Background: Respiratory distress syndrome [RDS] is among the most common diseases in preterm infants. Numerous causes of RDS have been recently diagnosed and researchers have identified the presence of low serum carnitine in preterm infants with RDS.The aim of this study: to evaluate serum carnitine...

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Autores principales:	Basma Ghoniem, Mohamed elsamanoudy
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	neonatal respiratory distress syndrome pulmonary immaturity carnitine deficiency Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fc0db06e335744fd8c27348e95bf87c3
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spelling	oai:doaj.org-article:fc0db06e335744fd8c27348e95bf87c32021-12-02T18:11:42ZSerum Carnitine Levels in Preterm Infants with Respiratory Distress Syndrome2636-41742682-378010.21608/ijma.2021.75951.1313https://doaj.org/article/fc0db06e335744fd8c27348e95bf87c32021-10-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_192770_b6cc9dfc12fbf1f8152a619875e7c8ee.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Respiratory distress syndrome [RDS] is among the most common diseases in preterm infants. Numerous causes of RDS have been recently diagnosed and researchers have identified the presence of low serum carnitine in preterm infants with RDS.The aim of this study: to evaluate serum carnitine levels in preterm infants with RDS.Patients and methods: Eighty preterm infants were divided into two groups; group 1 consisted of 50 preterm with RDS in the first 6h of life constituted Group [A] as they were preterm infants with RDS with normal serum carnitine levels while Group [B] represented infants with carnitine deficiency. Control group 2 consisted of 30 preterm infants without RDS in the first 6 h of life. All cases and their mothers included in the study were subjected to a thorough history taking, thorough clinical examination and measurement of serum carnitine.Results: The cases groups had significantly lower serum L-carnitine than the controls group [25.56 ± 11.14 vs. 34.53 ± 2.54], and carnitine deficiency in RDS cases [32%]. Concerning weight, cases with carnitine deficiency had higher weight than cases with normal carnitine and control. With regard to clinical manifestations, there was a statistically significant difference between the cases subgroups in Down score indicting severe RDS in cases with carnitine deficiency. There was a statistically significant difference among cases subgroups regarding radiological findings. The cases with carnitine deficiency had worse X-ray, more need for surfactant therapy and MV than the cases with normal carnitine.Conclusion: Preterm neonates with RDS were demonstrated to be associated with a significant reduction in carnitine level compared to RDS- free preterm ones.Basma GhoniemMohamed elsamanoudyAl-Azhar University, Faculty of Medicine (Damietta)articleneonatalrespiratory distress syndromepulmonary immaturitycarnitine deficiencyMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 4, Pp 1797-1802 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neonatal respiratory distress syndrome pulmonary immaturity carnitine deficiency Medicine (General) R5-920
spellingShingle	neonatal respiratory distress syndrome pulmonary immaturity carnitine deficiency Medicine (General) R5-920 Basma Ghoniem Mohamed elsamanoudy Serum Carnitine Levels in Preterm Infants with Respiratory Distress Syndrome
description	Background: Respiratory distress syndrome [RDS] is among the most common diseases in preterm infants. Numerous causes of RDS have been recently diagnosed and researchers have identified the presence of low serum carnitine in preterm infants with RDS.The aim of this study: to evaluate serum carnitine levels in preterm infants with RDS.Patients and methods: Eighty preterm infants were divided into two groups; group 1 consisted of 50 preterm with RDS in the first 6h of life constituted Group [A] as they were preterm infants with RDS with normal serum carnitine levels while Group [B] represented infants with carnitine deficiency. Control group 2 consisted of 30 preterm infants without RDS in the first 6 h of life. All cases and their mothers included in the study were subjected to a thorough history taking, thorough clinical examination and measurement of serum carnitine.Results: The cases groups had significantly lower serum L-carnitine than the controls group [25.56 ± 11.14 vs. 34.53 ± 2.54], and carnitine deficiency in RDS cases [32%]. Concerning weight, cases with carnitine deficiency had higher weight than cases with normal carnitine and control. With regard to clinical manifestations, there was a statistically significant difference between the cases subgroups in Down score indicting severe RDS in cases with carnitine deficiency. There was a statistically significant difference among cases subgroups regarding radiological findings. The cases with carnitine deficiency had worse X-ray, more need for surfactant therapy and MV than the cases with normal carnitine.Conclusion: Preterm neonates with RDS were demonstrated to be associated with a significant reduction in carnitine level compared to RDS- free preterm ones.
format	article
author	Basma Ghoniem Mohamed elsamanoudy
author_facet	Basma Ghoniem Mohamed elsamanoudy
author_sort	Basma Ghoniem
title	Serum Carnitine Levels in Preterm Infants with Respiratory Distress Syndrome
title_short	Serum Carnitine Levels in Preterm Infants with Respiratory Distress Syndrome
title_full	Serum Carnitine Levels in Preterm Infants with Respiratory Distress Syndrome
title_fullStr	Serum Carnitine Levels in Preterm Infants with Respiratory Distress Syndrome
title_full_unstemmed	Serum Carnitine Levels in Preterm Infants with Respiratory Distress Syndrome
title_sort	serum carnitine levels in preterm infants with respiratory distress syndrome
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/fc0db06e335744fd8c27348e95bf87c3
work_keys_str_mv	AT basmaghoniem serumcarnitinelevelsinpreterminfantswithrespiratorydistresssyndrome AT mohamedelsamanoudy serumcarnitinelevelsinpreterminfantswithrespiratorydistresssyndrome
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Serum Carnitine Levels in Preterm Infants with Respiratory Distress Syndrome

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