The place of fixed antihypertensive drugs in modern therapy of arterial hypertension

The article provides information on modern approaches to the treatment of arterial hypertension. The historical information about therapy with combined antihypertensive drugs is given. Based on data from multicenter clinical trials, the article provides evidence of the benefits of dual and triple fi...

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Main Authors:	Tatiana V. Pinchuk, Natalia V. Orlova
Format:	article
Language:	RU
Published:	IP Morozov P.V. 2021
Subjects:	arterial hypertension antihypertensive drugs fixed combinations triple combinations treatment adherence Diseases of the circulatory (Cardiovascular) system RC666-701
Online Access:	https://doaj.org/article/fc0fe2e21ed34098931d6945efeb1a1c
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spelling	oai:doaj.org-article:fc0fe2e21ed34098931d6945efeb1a1c2021-11-30T16:09:16ZThe place of fixed antihypertensive drugs in modern therapy of arterial hypertension2075-082X2542-218910.26442/2075082X.2020.4.200035https://doaj.org/article/fc0fe2e21ed34098931d6945efeb1a1c2021-02-01T00:00:00Zhttps://syst-hypertension.ru/2075-082X/article/viewFile/60282/43451https://doaj.org/toc/2075-082Xhttps://doaj.org/toc/2542-2189The article provides information on modern approaches to the treatment of arterial hypertension. The historical information about therapy with combined antihypertensive drugs is given. Based on data from multicenter clinical trials, the article provides evidence of the benefits of dual and triple fixed drug combinations. Combinations of 1-adrenoreceptor antagonist bisoprolol and the dihydropyridine-type calcium channel blocker amlodipine are considered. The article highlights the advantages of each of the drugs, as well as their combination. It shows the benefits of a fixed combination of low and medium doses compared to high-dose monotherapy, such as efficacy in achieving target blood pressure, preventing cardiovascular events, increasing adherence to treatment, safety and development of side effects. It provides the evidence base for the effectiveness of a triple fixed combination of renin-angiotensin-aldosterone system blockers with calcium channel blockers and diuretics in achieving target blood pressure compared to a double fixed combination of members of these drug classes, which is due to additive effects. The safety and tolerability profiles were found to be more effective with triple therapy compared with dual therapy, which is also supported by studies.Tatiana V. PinchukNatalia V. OrlovaIP Morozov P.V.articlearterial hypertensionantihypertensive drugsfixed combinationstriple combinationstreatmentadherenceDiseases of the circulatory (Cardiovascular) systemRC666-701RUСистемные гипертензии, Vol 17, Iss 4, Pp 44-48 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	arterial hypertension antihypertensive drugs fixed combinations triple combinations treatment adherence Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	arterial hypertension antihypertensive drugs fixed combinations triple combinations treatment adherence Diseases of the circulatory (Cardiovascular) system RC666-701 Tatiana V. Pinchuk Natalia V. Orlova The place of fixed antihypertensive drugs in modern therapy of arterial hypertension
description	The article provides information on modern approaches to the treatment of arterial hypertension. The historical information about therapy with combined antihypertensive drugs is given. Based on data from multicenter clinical trials, the article provides evidence of the benefits of dual and triple fixed drug combinations. Combinations of 1-adrenoreceptor antagonist bisoprolol and the dihydropyridine-type calcium channel blocker amlodipine are considered. The article highlights the advantages of each of the drugs, as well as their combination. It shows the benefits of a fixed combination of low and medium doses compared to high-dose monotherapy, such as efficacy in achieving target blood pressure, preventing cardiovascular events, increasing adherence to treatment, safety and development of side effects. It provides the evidence base for the effectiveness of a triple fixed combination of renin-angiotensin-aldosterone system blockers with calcium channel blockers and diuretics in achieving target blood pressure compared to a double fixed combination of members of these drug classes, which is due to additive effects. The safety and tolerability profiles were found to be more effective with triple therapy compared with dual therapy, which is also supported by studies.
format	article
author	Tatiana V. Pinchuk Natalia V. Orlova
author_facet	Tatiana V. Pinchuk Natalia V. Orlova
author_sort	Tatiana V. Pinchuk
title	The place of fixed antihypertensive drugs in modern therapy of arterial hypertension
title_short	The place of fixed antihypertensive drugs in modern therapy of arterial hypertension
title_full	The place of fixed antihypertensive drugs in modern therapy of arterial hypertension
title_fullStr	The place of fixed antihypertensive drugs in modern therapy of arterial hypertension
title_full_unstemmed	The place of fixed antihypertensive drugs in modern therapy of arterial hypertension
title_sort	place of fixed antihypertensive drugs in modern therapy of arterial hypertension
publisher	IP Morozov P.V.
publishDate	2021
url	https://doaj.org/article/fc0fe2e21ed34098931d6945efeb1a1c
work_keys_str_mv	AT tatianavpinchuk theplaceoffixedantihypertensivedrugsinmoderntherapyofarterialhypertension AT nataliavorlova theplaceoffixedantihypertensivedrugsinmoderntherapyofarterialhypertension AT tatianavpinchuk placeoffixedantihypertensivedrugsinmoderntherapyofarterialhypertension AT nataliavorlova placeoffixedantihypertensivedrugsinmoderntherapyofarterialhypertension
_version_	1718406480680452096

The place of fixed antihypertensive drugs in modern therapy of arterial hypertension

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