Pro-Tumor and Anti-Tumor Functions of IL-17 and of TH17 Cells in Tumor Microenvironment

The current review reveals the seven subclasses of CD4+ T helper cells, i.e. Th1, Th2, Th9, Th17, Th22, regulatory T cells and Tfh, the cytokines produced by them and their role in tumor microenvironment. Main attention was paid to IL-17 and Th17 cells. IL-17-producing cells were described, among wh...

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Autores principales:	Gulubova M., Ananiev J., Ignatova M., Halacheva K.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	il-17 th17 cells tumor microenvironment Medicine R
Acceso en línea:	https://doaj.org/article/fc0fe41ec39d4b96aff6855511b82fcd
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spelling	oai:doaj.org-article:fc0fe41ec39d4b96aff6855511b82fcd2021-12-02T19:17:53ZPro-Tumor and Anti-Tumor Functions of IL-17 and of TH17 Cells in Tumor Microenvironment0324-175010.1515/amb-2016-0019https://doaj.org/article/fc0fe41ec39d4b96aff6855511b82fcd2016-10-01T00:00:00Zhttps://doi.org/10.1515/amb-2016-0019https://doaj.org/toc/0324-1750The current review reveals the seven subclasses of CD4+ T helper cells, i.e. Th1, Th2, Th9, Th17, Th22, regulatory T cells and Tfh, the cytokines produced by them and their role in tumor microenvironment. Main attention was paid to IL-17 and Th17 cells. IL-17-producing cells were described, among which were Treg17 cells and Tc17 cells. The transcription factors, engaged in the activation of Th17 cell differentiation were reviewed. It was shown that Th17 cells might possess regulatory functions in tumor microenvironments that directs toward immunosuppression. The reciprocity between Treg and Th17 cells is realized when the production of a large amount of TGF-β in tumors causes Treg cell differentiation, and the addition of IL-6 shifts the differentiation of naïve T cells to Th17 cells. The main pro-tumor role of IL-17 is the promotion of tumor angiogenesis through stimulation of fibroblasts and endothelial cells. The antitumor functions of IL-17 are associated with enhancement of cytotoxic activity of tumor specific CTL cells and with angiogenesis that provide channels through which immune cells might invade tumor and promote antitumor immunity.Gulubova M.Ananiev J.Ignatova M.Halacheva K.Sciendoarticleil-17th17 cellstumor microenvironmentMedicineRENActa Medica Bulgarica, Vol 43, Iss 2, Pp 68-79 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	il-17 th17 cells tumor microenvironment Medicine R
spellingShingle	il-17 th17 cells tumor microenvironment Medicine R Gulubova M. Ananiev J. Ignatova M. Halacheva K. Pro-Tumor and Anti-Tumor Functions of IL-17 and of TH17 Cells in Tumor Microenvironment
description	The current review reveals the seven subclasses of CD4+ T helper cells, i.e. Th1, Th2, Th9, Th17, Th22, regulatory T cells and Tfh, the cytokines produced by them and their role in tumor microenvironment. Main attention was paid to IL-17 and Th17 cells. IL-17-producing cells were described, among which were Treg17 cells and Tc17 cells. The transcription factors, engaged in the activation of Th17 cell differentiation were reviewed. It was shown that Th17 cells might possess regulatory functions in tumor microenvironments that directs toward immunosuppression. The reciprocity between Treg and Th17 cells is realized when the production of a large amount of TGF-β in tumors causes Treg cell differentiation, and the addition of IL-6 shifts the differentiation of naïve T cells to Th17 cells. The main pro-tumor role of IL-17 is the promotion of tumor angiogenesis through stimulation of fibroblasts and endothelial cells. The antitumor functions of IL-17 are associated with enhancement of cytotoxic activity of tumor specific CTL cells and with angiogenesis that provide channels through which immune cells might invade tumor and promote antitumor immunity.
format	article
author	Gulubova M. Ananiev J. Ignatova M. Halacheva K.
author_facet	Gulubova M. Ananiev J. Ignatova M. Halacheva K.
author_sort	Gulubova M.
title	Pro-Tumor and Anti-Tumor Functions of IL-17 and of TH17 Cells in Tumor Microenvironment
title_short	Pro-Tumor and Anti-Tumor Functions of IL-17 and of TH17 Cells in Tumor Microenvironment
title_full	Pro-Tumor and Anti-Tumor Functions of IL-17 and of TH17 Cells in Tumor Microenvironment
title_fullStr	Pro-Tumor and Anti-Tumor Functions of IL-17 and of TH17 Cells in Tumor Microenvironment
title_full_unstemmed	Pro-Tumor and Anti-Tumor Functions of IL-17 and of TH17 Cells in Tumor Microenvironment
title_sort	pro-tumor and anti-tumor functions of il-17 and of th17 cells in tumor microenvironment
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/fc0fe41ec39d4b96aff6855511b82fcd
work_keys_str_mv	AT gulubovam protumorandantitumorfunctionsofil17andofth17cellsintumormicroenvironment AT ananievj protumorandantitumorfunctionsofil17andofth17cellsintumormicroenvironment AT ignatovam protumorandantitumorfunctionsofil17andofth17cellsintumormicroenvironment AT halachevak protumorandantitumorfunctionsofil17andofth17cellsintumormicroenvironment
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Pro-Tumor and Anti-Tumor Functions of IL-17 and of TH17 Cells in Tumor Microenvironment

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