Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth
Tumour-associated macrophages (TAMs) facilitate malignant growth of glioblastoma (GBM). Here, the authors show that TAMs support glioma stem cell renewal via paracrine signalling to the pleiotrophin receptor PTPRZ1 and that blocking this axis results in increased survival of tumour-bearing animals.
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Nature Portfolio
2017
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oai:doaj.org-article:fc10d4b4ab8a4e3cb428bc0e733826492021-12-02T14:42:17ZTumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth10.1038/ncomms150802041-1723https://doaj.org/article/fc10d4b4ab8a4e3cb428bc0e733826492017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15080https://doaj.org/toc/2041-1723Tumour-associated macrophages (TAMs) facilitate malignant growth of glioblastoma (GBM). Here, the authors show that TAMs support glioma stem cell renewal via paracrine signalling to the pleiotrophin receptor PTPRZ1 and that blocking this axis results in increased survival of tumour-bearing animals.Yu ShiYi-Fang PingWenchao ZhouZhi-Cheng HeCong ChenBai-Shi-Jiao BianLin ZhangLu ChenXun LanXian-Chao ZhangKai ZhouQing LiuHua LongTi-Wei FuXiao-Ning ZhangMian-Fu CaoZhi HuangXiaoguang FangXiuxing WangHua FengXiao-Hong YaoShi-Cang YuYou-Hong CuiXia ZhangJeremy N RichShideng BaoXiu-Wu BianNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017) |
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DOAJ |
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| topic |
Science Q |
| spellingShingle |
Science Q Yu Shi Yi-Fang Ping Wenchao Zhou Zhi-Cheng He Cong Chen Bai-Shi-Jiao Bian Lin Zhang Lu Chen Xun Lan Xian-Chao Zhang Kai Zhou Qing Liu Hua Long Ti-Wei Fu Xiao-Ning Zhang Mian-Fu Cao Zhi Huang Xiaoguang Fang Xiuxing Wang Hua Feng Xiao-Hong Yao Shi-Cang Yu You-Hong Cui Xia Zhang Jeremy N Rich Shideng Bao Xiu-Wu Bian Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth |
| description |
Tumour-associated macrophages (TAMs) facilitate malignant growth of glioblastoma (GBM). Here, the authors show that TAMs support glioma stem cell renewal via paracrine signalling to the pleiotrophin receptor PTPRZ1 and that blocking this axis results in increased survival of tumour-bearing animals. |
| format |
article |
| author |
Yu Shi Yi-Fang Ping Wenchao Zhou Zhi-Cheng He Cong Chen Bai-Shi-Jiao Bian Lin Zhang Lu Chen Xun Lan Xian-Chao Zhang Kai Zhou Qing Liu Hua Long Ti-Wei Fu Xiao-Ning Zhang Mian-Fu Cao Zhi Huang Xiaoguang Fang Xiuxing Wang Hua Feng Xiao-Hong Yao Shi-Cang Yu You-Hong Cui Xia Zhang Jeremy N Rich Shideng Bao Xiu-Wu Bian |
| author_facet |
Yu Shi Yi-Fang Ping Wenchao Zhou Zhi-Cheng He Cong Chen Bai-Shi-Jiao Bian Lin Zhang Lu Chen Xun Lan Xian-Chao Zhang Kai Zhou Qing Liu Hua Long Ti-Wei Fu Xiao-Ning Zhang Mian-Fu Cao Zhi Huang Xiaoguang Fang Xiuxing Wang Hua Feng Xiao-Hong Yao Shi-Cang Yu You-Hong Cui Xia Zhang Jeremy N Rich Shideng Bao Xiu-Wu Bian |
| author_sort |
Yu Shi |
| title |
Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth |
| title_short |
Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth |
| title_full |
Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth |
| title_fullStr |
Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth |
| title_full_unstemmed |
Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth |
| title_sort |
tumour-associated macrophages secrete pleiotrophin to promote ptprz1 signalling in glioblastoma stem cells for tumour growth |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/fc10d4b4ab8a4e3cb428bc0e73382649 |
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