Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair

Zebrafish can regenerate damaged myocardial tissue but it is unclear how this is regulated. Here, the authors show that two TGF-β family members, Mstnb and Inhbaa, have opposite effects in regeneration, with mstnb overexpression or inhbaa loss-of-function causing cardiac scarring after injury.

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Autores principales:	Deepika Dogra, Suchit Ahuja, Hyun-Taek Kim, S. Javad Rasouli, Didier Y. R. Stainier, Sven Reischauer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fc12044a70574a67a382a1e8e1be1850
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spelling	oai:doaj.org-article:fc12044a70574a67a382a1e8e1be18502021-12-02T15:39:03ZOpposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair10.1038/s41467-017-01950-12041-1723https://doaj.org/article/fc12044a70574a67a382a1e8e1be18502017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01950-1https://doaj.org/toc/2041-1723Zebrafish can regenerate damaged myocardial tissue but it is unclear how this is regulated. Here, the authors show that two TGF-β family members, Mstnb and Inhbaa, have opposite effects in regeneration, with mstnb overexpression or inhbaa loss-of-function causing cardiac scarring after injury.Deepika DograSuchit AhujaHyun-Taek KimS. Javad RasouliDidier Y. R. StainierSven ReischauerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deepika Dogra Suchit Ahuja Hyun-Taek Kim S. Javad Rasouli Didier Y. R. Stainier Sven Reischauer Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair
description	Zebrafish can regenerate damaged myocardial tissue but it is unclear how this is regulated. Here, the authors show that two TGF-β family members, Mstnb and Inhbaa, have opposite effects in regeneration, with mstnb overexpression or inhbaa loss-of-function causing cardiac scarring after injury.
format	article
author	Deepika Dogra Suchit Ahuja Hyun-Taek Kim S. Javad Rasouli Didier Y. R. Stainier Sven Reischauer
author_facet	Deepika Dogra Suchit Ahuja Hyun-Taek Kim S. Javad Rasouli Didier Y. R. Stainier Sven Reischauer
author_sort	Deepika Dogra
title	Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair
title_short	Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair
title_full	Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair
title_fullStr	Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair
title_full_unstemmed	Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair
title_sort	opposite effects of activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fc12044a70574a67a382a1e8e1be1850
work_keys_str_mv	AT deepikadogra oppositeeffectsofactivintype2receptorligandsoncardiomyocyteproliferationduringdevelopmentandrepair AT suchitahuja oppositeeffectsofactivintype2receptorligandsoncardiomyocyteproliferationduringdevelopmentandrepair AT hyuntaekkim oppositeeffectsofactivintype2receptorligandsoncardiomyocyteproliferationduringdevelopmentandrepair AT sjavadrasouli oppositeeffectsofactivintype2receptorligandsoncardiomyocyteproliferationduringdevelopmentandrepair AT didieryrstainier oppositeeffectsofactivintype2receptorligandsoncardiomyocyteproliferationduringdevelopmentandrepair AT svenreischauer oppositeeffectsofactivintype2receptorligandsoncardiomyocyteproliferationduringdevelopmentandrepair
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Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair

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