PREDICTING THE RISK OF PROTHROMBOTIC CHANGES IN ADOLESCENTS WITH ESSENTIAL HYPERTENSION

Today, the problem of early diagnosis of hematological changes predisposing to the development of thrombotic complications in patients with essential hypertension (EH) is an urgent problem that requires close attention not only of physicians, but also of pediatricians. The aim of the study was the d...

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Autores principales:	S. E. Bolshakova, M. V. Gomellya, T. A. Bairova, O. N. Berdina, O. V. Bugun, I. M. Mikhalevich, L. V. Rychkova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	adolescents genes essential hypertension prothrombotic changes thrombosis Science Q
Acceso en línea:	https://doaj.org/article/fc17f506649447afbfc199d010b76104
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spelling	oai:doaj.org-article:fc17f506649447afbfc199d010b761042021-11-23T06:14:38ZPREDICTING THE RISK OF PROTHROMBOTIC CHANGES IN ADOLESCENTS WITH ESSENTIAL HYPERTENSION2541-94202587-959610.12737/article_59fad515bbca24.82856461https://doaj.org/article/fc17f506649447afbfc199d010b761042017-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/413https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Today, the problem of early diagnosis of hematological changes predisposing to the development of thrombotic complications in patients with essential hypertension (EH) is an urgent problem that requires close attention not only of physicians, but also of pediatricians. The aim of the study was the development of prognostic criteria for risk of prothrombotic changes (PC) in adolescents with EH, timely preventive measures and prevention of thrombotic complications. Sixty adolescents with EH without PC and 37 adolescents with EH and PC were examined. We used the following methods: clinical anamnestic (including genealogy), functional and ultrasound, laboratory, mathematical and statistical. To create a mathematical model of forecasting, discriminant analysis was used, with the help of which from the 59 proposed predictors the algorithm selected 8 most informative features: the C777T polymorphism of the 5,10-methylenetetrahydrofolate reductase gene, the A66G gene of the methionine synthase reductase gene, the daily diastolic blood pressure level, the level of the nocturnal systolic arterial pressure-time index of hypertension, systolic blood pressure during the day, weighed down by thrombotic genealogically history, early onset of thrombosis, burdened thrombotic genealogical history. Our method for predicting the risk of developing PC allows to place adolescents with EH having an increased risk of developing these coagulation shifts in a separate group, to identify thrombogenic risk in adolescence and, if necessary, to initiate preventive measures in time to reduce the incidence of thrombotic complications of EH and mortality of patients.S. E. BolshakovaM. V. GomellyaT. A. BairovaO. N. BerdinaO. V. BugunI. M. MikhalevichL. V. RychkovaScientific Сentre for Family Health and Human Reproduction Problemsarticleadolescentsgenesessential hypertensionprothrombotic changesthrombosisScienceQRUActa Biomedica Scientifica, Vol 2, Iss 4, Pp 58-62 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	adolescents genes essential hypertension prothrombotic changes thrombosis Science Q
spellingShingle	adolescents genes essential hypertension prothrombotic changes thrombosis Science Q S. E. Bolshakova M. V. Gomellya T. A. Bairova O. N. Berdina O. V. Bugun I. M. Mikhalevich L. V. Rychkova PREDICTING THE RISK OF PROTHROMBOTIC CHANGES IN ADOLESCENTS WITH ESSENTIAL HYPERTENSION
description	Today, the problem of early diagnosis of hematological changes predisposing to the development of thrombotic complications in patients with essential hypertension (EH) is an urgent problem that requires close attention not only of physicians, but also of pediatricians. The aim of the study was the development of prognostic criteria for risk of prothrombotic changes (PC) in adolescents with EH, timely preventive measures and prevention of thrombotic complications. Sixty adolescents with EH without PC and 37 adolescents with EH and PC were examined. We used the following methods: clinical anamnestic (including genealogy), functional and ultrasound, laboratory, mathematical and statistical. To create a mathematical model of forecasting, discriminant analysis was used, with the help of which from the 59 proposed predictors the algorithm selected 8 most informative features: the C777T polymorphism of the 5,10-methylenetetrahydrofolate reductase gene, the A66G gene of the methionine synthase reductase gene, the daily diastolic blood pressure level, the level of the nocturnal systolic arterial pressure-time index of hypertension, systolic blood pressure during the day, weighed down by thrombotic genealogically history, early onset of thrombosis, burdened thrombotic genealogical history. Our method for predicting the risk of developing PC allows to place adolescents with EH having an increased risk of developing these coagulation shifts in a separate group, to identify thrombogenic risk in adolescence and, if necessary, to initiate preventive measures in time to reduce the incidence of thrombotic complications of EH and mortality of patients.
format	article
author	S. E. Bolshakova M. V. Gomellya T. A. Bairova O. N. Berdina O. V. Bugun I. M. Mikhalevich L. V. Rychkova
author_facet	S. E. Bolshakova M. V. Gomellya T. A. Bairova O. N. Berdina O. V. Bugun I. M. Mikhalevich L. V. Rychkova
author_sort	S. E. Bolshakova
title	PREDICTING THE RISK OF PROTHROMBOTIC CHANGES IN ADOLESCENTS WITH ESSENTIAL HYPERTENSION
title_short	PREDICTING THE RISK OF PROTHROMBOTIC CHANGES IN ADOLESCENTS WITH ESSENTIAL HYPERTENSION
title_full	PREDICTING THE RISK OF PROTHROMBOTIC CHANGES IN ADOLESCENTS WITH ESSENTIAL HYPERTENSION
title_fullStr	PREDICTING THE RISK OF PROTHROMBOTIC CHANGES IN ADOLESCENTS WITH ESSENTIAL HYPERTENSION
title_full_unstemmed	PREDICTING THE RISK OF PROTHROMBOTIC CHANGES IN ADOLESCENTS WITH ESSENTIAL HYPERTENSION
title_sort	predicting the risk of prothrombotic changes in adolescents with essential hypertension
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/fc17f506649447afbfc199d010b76104
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PREDICTING THE RISK OF PROTHROMBOTIC CHANGES IN ADOLESCENTS WITH ESSENTIAL HYPERTENSION

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