Respiratory epithelium: Place of entry and / or defense against SARS-CoV-2 virus

Coronavirus Disease (COVID-19) is caused by the RNA virus SARS-CoV-2. The primary receptor for the virus is most likely Angiotensin-converting enzyme 2 (ACE2), and the virus enters the body by infecting epithelial cells of the respiratory tract. Through the activation of Toll Like Receptors (TLRs),...

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Autores principales:	Leštarević Snežana, Savić Slađana, Vitković Leonida, Mandić Predrag, Mijović Milica, Dejanović Mirjana, Marjanović Dragan, Rančić Ivan, Filipović Milan
Formato:	article
Lenguaje:	EN SR
Publicado:	Medicinski fakultet Priština, Društvo lekara Kosova i Metohije Srpskog lekarskog društva 2021
Materias:	sars-cov-2 virus respiratory system immune response cytokine storm Medicine R
Acceso en línea:	https://doaj.org/article/fc1921ed0d03466c848800e17dcc642c
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spelling	oai:doaj.org-article:fc1921ed0d03466c848800e17dcc642c2021-12-05T21:29:52ZRespiratory epithelium: Place of entry and / or defense against SARS-CoV-2 virus0350-87732560-331010.5937/pramed2102035Lhttps://doaj.org/article/fc1921ed0d03466c848800e17dcc642c2021-01-01T00:00:00Zhttps://scindeks-clanci.ceon.rs/data/pdf/0350-8773/2021/0350-87732101035L.pdfhttps://doaj.org/toc/0350-8773https://doaj.org/toc/2560-3310Coronavirus Disease (COVID-19) is caused by the RNA virus SARS-CoV-2. The primary receptor for the virus is most likely Angiotensin-converting enzyme 2 (ACE2), and the virus enters the body by infecting epithelial cells of the respiratory tract. Through the activation of Toll Like Receptors (TLRs), epithelial cells begin to synthesize various biologically active molecules. The pathophysiology of the COVID 19 is primarily attributed to the hyperactivation of host's immune system due to direct damage to the cells, with consequent release of proinflammatory substances, but also due to the activation of the innate immune response through the activation of alveolar macrophages and dendrite cells (DC). A strong proinflammatory reaction causes damage to alveolar epithelial cells and vascular endothelium. Respiratory epithelial cells, alveolar macrophages and DC are likely to be the most important cells involved in the innate immune response to the virus, since prolonged and excessive SARS-CoV-2-induced activation of these cells leads to the secretion of cytokines and chemokines that massively attract leukocytes and monocytes to the lungs and cause lung damage.Leštarević SnežanaSavić SlađanaVitković LeonidaMandić PredragMijović MilicaDejanović MirjanaMarjanović DraganRančić IvanFilipović MilanMedicinski fakultet Priština, Društvo lekara Kosova i Metohije Srpskog lekarskog društvaarticlesars-cov-2 virusrespiratory systemimmune responsecytokine stormMedicineRENSRPraxis Medica, Vol 50, Iss 1-2, Pp 35-43 (2021)
institution	DOAJ
collection	DOAJ
language	EN SR
topic	sars-cov-2 virus respiratory system immune response cytokine storm Medicine R
spellingShingle	sars-cov-2 virus respiratory system immune response cytokine storm Medicine R Leštarević Snežana Savić Slađana Vitković Leonida Mandić Predrag Mijović Milica Dejanović Mirjana Marjanović Dragan Rančić Ivan Filipović Milan Respiratory epithelium: Place of entry and / or defense against SARS-CoV-2 virus
description	Coronavirus Disease (COVID-19) is caused by the RNA virus SARS-CoV-2. The primary receptor for the virus is most likely Angiotensin-converting enzyme 2 (ACE2), and the virus enters the body by infecting epithelial cells of the respiratory tract. Through the activation of Toll Like Receptors (TLRs), epithelial cells begin to synthesize various biologically active molecules. The pathophysiology of the COVID 19 is primarily attributed to the hyperactivation of host's immune system due to direct damage to the cells, with consequent release of proinflammatory substances, but also due to the activation of the innate immune response through the activation of alveolar macrophages and dendrite cells (DC). A strong proinflammatory reaction causes damage to alveolar epithelial cells and vascular endothelium. Respiratory epithelial cells, alveolar macrophages and DC are likely to be the most important cells involved in the innate immune response to the virus, since prolonged and excessive SARS-CoV-2-induced activation of these cells leads to the secretion of cytokines and chemokines that massively attract leukocytes and monocytes to the lungs and cause lung damage.
format	article
author	Leštarević Snežana Savić Slađana Vitković Leonida Mandić Predrag Mijović Milica Dejanović Mirjana Marjanović Dragan Rančić Ivan Filipović Milan
author_facet	Leštarević Snežana Savić Slađana Vitković Leonida Mandić Predrag Mijović Milica Dejanović Mirjana Marjanović Dragan Rančić Ivan Filipović Milan
author_sort	Leštarević Snežana
title	Respiratory epithelium: Place of entry and / or defense against SARS-CoV-2 virus
title_short	Respiratory epithelium: Place of entry and / or defense against SARS-CoV-2 virus
title_full	Respiratory epithelium: Place of entry and / or defense against SARS-CoV-2 virus
title_fullStr	Respiratory epithelium: Place of entry and / or defense against SARS-CoV-2 virus
title_full_unstemmed	Respiratory epithelium: Place of entry and / or defense against SARS-CoV-2 virus
title_sort	respiratory epithelium: place of entry and / or defense against sars-cov-2 virus
publisher	Medicinski fakultet Priština, Društvo lekara Kosova i Metohije Srpskog lekarskog društva
publishDate	2021
url	https://doaj.org/article/fc1921ed0d03466c848800e17dcc642c
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Respiratory epithelium: Place of entry and / or defense against SARS-CoV-2 virus

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