A novel bone cement impregnated with silver–tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties
Polina Prokopovich,1,2 Ralph Leech,3 Claire J Carmalt,3 Ivan P Parkin,3 Stefano Perni41School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK; 2Institute of Medical Engineering and Medical Physics, School of Engineering, Cardiff University, Cardiff, UK; 3Materials Chemistry...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2013
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/fc1adb9b5e004eb291ef327e1bd0f095 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:fc1adb9b5e004eb291ef327e1bd0f095 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:fc1adb9b5e004eb291ef327e1bd0f0952021-12-02T07:47:00ZA novel bone cement impregnated with silver–tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties1176-91141178-2013https://doaj.org/article/fc1adb9b5e004eb291ef327e1bd0f0952013-06-01T00:00:00Zhttp://www.dovepress.com/a-novel-bone-cement-impregnated-with-silverndashtiopronin-nanoparticle-a13390https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Polina Prokopovich,1,2 Ralph Leech,3 Claire J Carmalt,3 Ivan P Parkin,3 Stefano Perni41School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK; 2Institute of Medical Engineering and Medical Physics, School of Engineering, Cardiff University, Cardiff, UK; 3Materials Chemistry Research Centre, Department of Chemistry, University College London, London, UK; 4School of Chemical Engineering, University of Birmingham, Birmingham, UKAbstract: Post-operatory infections in orthopedic surgeries pose a significant risk. The common approach of using antibiotics, both parenterally or embedded in bone cement (when this is employed during surgery) faces the challenge of the rising population of pathogens exhibiting resistance properties against one or more of these compounds; therefore, novel approaches need to be developed. Silver nanoparticles appear to be an exciting prospect because of their antimicrobial activity and safety at the levels used in medical applications. In this paper, a novel type of silver nanoparticles capped with tiopronin is presented. Two ratios of reagents during synthesis were tested and the effect on the nanoparticles investigated through TEM, TGA, and UV-Vis spectroscopy. Once encapsulated in bone cement, only the nanoparticles with the highest amount of inorganic fraction conferred antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA) at concentrations as low as 0.1% w/w. No other characteristics of the bone cement, such as cytotoxicity or mechanical properties, were affected by the presence of the nanoparticles. Our work presents a new type of silver nanoparticles and demonstrates that they can be embedded in bone cement to prevent infections once the synthetic conditions are tailored for such applications.Keywords: bone cement, antimicrobial, silver nanoparticles, tiopronin, MRSAProkopovich PLeech RCarmalt CJParkin IPPerni SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 2227-2237 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine (General) R5-920 |
| spellingShingle |
Medicine (General) R5-920 Prokopovich P Leech R Carmalt CJ Parkin IP Perni S A novel bone cement impregnated with silver–tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties |
| description |
Polina Prokopovich,1,2 Ralph Leech,3 Claire J Carmalt,3 Ivan P Parkin,3 Stefano Perni41School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK; 2Institute of Medical Engineering and Medical Physics, School of Engineering, Cardiff University, Cardiff, UK; 3Materials Chemistry Research Centre, Department of Chemistry, University College London, London, UK; 4School of Chemical Engineering, University of Birmingham, Birmingham, UKAbstract: Post-operatory infections in orthopedic surgeries pose a significant risk. The common approach of using antibiotics, both parenterally or embedded in bone cement (when this is employed during surgery) faces the challenge of the rising population of pathogens exhibiting resistance properties against one or more of these compounds; therefore, novel approaches need to be developed. Silver nanoparticles appear to be an exciting prospect because of their antimicrobial activity and safety at the levels used in medical applications. In this paper, a novel type of silver nanoparticles capped with tiopronin is presented. Two ratios of reagents during synthesis were tested and the effect on the nanoparticles investigated through TEM, TGA, and UV-Vis spectroscopy. Once encapsulated in bone cement, only the nanoparticles with the highest amount of inorganic fraction conferred antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA) at concentrations as low as 0.1% w/w. No other characteristics of the bone cement, such as cytotoxicity or mechanical properties, were affected by the presence of the nanoparticles. Our work presents a new type of silver nanoparticles and demonstrates that they can be embedded in bone cement to prevent infections once the synthetic conditions are tailored for such applications.Keywords: bone cement, antimicrobial, silver nanoparticles, tiopronin, MRSA |
| format |
article |
| author |
Prokopovich P Leech R Carmalt CJ Parkin IP Perni S |
| author_facet |
Prokopovich P Leech R Carmalt CJ Parkin IP Perni S |
| author_sort |
Prokopovich P |
| title |
A novel bone cement impregnated with silver–tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties |
| title_short |
A novel bone cement impregnated with silver–tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties |
| title_full |
A novel bone cement impregnated with silver–tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties |
| title_fullStr |
A novel bone cement impregnated with silver–tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties |
| title_full_unstemmed |
A novel bone cement impregnated with silver–tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties |
| title_sort |
novel bone cement impregnated with silver–tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties |
| publisher |
Dove Medical Press |
| publishDate |
2013 |
| url |
https://doaj.org/article/fc1adb9b5e004eb291ef327e1bd0f095 |
| work_keys_str_mv |
AT prokopovichp anovelbonecementimpregnatedwithsilverndashtioproninnanoparticlesitsantimicrobialcytotoxicandmechanicalproperties AT leechr anovelbonecementimpregnatedwithsilverndashtioproninnanoparticlesitsantimicrobialcytotoxicandmechanicalproperties AT carmaltcj anovelbonecementimpregnatedwithsilverndashtioproninnanoparticlesitsantimicrobialcytotoxicandmechanicalproperties AT parkinip anovelbonecementimpregnatedwithsilverndashtioproninnanoparticlesitsantimicrobialcytotoxicandmechanicalproperties AT pernis anovelbonecementimpregnatedwithsilverndashtioproninnanoparticlesitsantimicrobialcytotoxicandmechanicalproperties AT prokopovichp novelbonecementimpregnatedwithsilverndashtioproninnanoparticlesitsantimicrobialcytotoxicandmechanicalproperties AT leechr novelbonecementimpregnatedwithsilverndashtioproninnanoparticlesitsantimicrobialcytotoxicandmechanicalproperties AT carmaltcj novelbonecementimpregnatedwithsilverndashtioproninnanoparticlesitsantimicrobialcytotoxicandmechanicalproperties AT parkinip novelbonecementimpregnatedwithsilverndashtioproninnanoparticlesitsantimicrobialcytotoxicandmechanicalproperties AT pernis novelbonecementimpregnatedwithsilverndashtioproninnanoparticlesitsantimicrobialcytotoxicandmechanicalproperties |
| _version_ |
1718399196635070464 |