SARS-CoV-2 Seroprevalence among a Southern U.S. Population Indicates Limited Asymptomatic Spread under Physical Distancing Measures
ABSTRACT Characterizing the asymptomatic spread of SARS-CoV-2 is important for understanding the COVID-19 pandemic. This study was aimed at determining asymptomatic spread of SARS-CoV-2 in a suburban, Southern U.S. population during a period of state restrictions and physical distancing mandates. Th...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
American Society for Microbiology
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/fc1d5c1e83274491868c6782f4af6c9d |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:fc1d5c1e83274491868c6782f4af6c9d |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:fc1d5c1e83274491868c6782f4af6c9d2021-11-15T16:19:07ZSARS-CoV-2 Seroprevalence among a Southern U.S. Population Indicates Limited Asymptomatic Spread under Physical Distancing Measures10.1128/mBio.02426-202150-7511https://doaj.org/article/fc1d5c1e83274491868c6782f4af6c9d2020-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02426-20https://doaj.org/toc/2150-7511ABSTRACT Characterizing the asymptomatic spread of SARS-CoV-2 is important for understanding the COVID-19 pandemic. This study was aimed at determining asymptomatic spread of SARS-CoV-2 in a suburban, Southern U.S. population during a period of state restrictions and physical distancing mandates. This is one of the first published seroprevalence studies from North Carolina and included multicenter, primary care, and emergency care facilities serving a low-density, suburban and rural population since description of the North Carolina state index case introducing the SARS-CoV-2 respiratory pathogen to this population. To estimate point seroprevalence of SARS-CoV-2 among asymptomatic individuals over time, two cohort studies were examined. The first cohort study, named ScreenNC, was comprised of outpatient clinics, and the second cohort study, named ScreenNC2, was comprised of inpatients unrelated to COVID-19. Asymptomatic infection by SARS-CoV-2 (with no clinical symptoms) was examined using an Emergency Use Authorization (EUA)-approved antibody test (Abbott) for the presence of SARS-CoV-2 IgG. This assay as performed under CLIA had a reported specificity/sensitivity of 100%/99.6%. ScreenNC identified 24 out of 2,973 (0.8%) positive individuals among asymptomatic participants accessing health care during 28 April to 19 June 2020, which was increasing over time. A separate cohort, ScreenNC2, sampled from 3 March to 4 June 2020, identified 10 out of 1,449 (0.7%) positive participants. IMPORTANCE This study suggests limited but accelerating asymptomatic spread of SARS-CoV-2. Asymptomatic infections, like symptomatic infections, disproportionately affected vulnerable communities in this population, and seroprevalence was higher in African American participants than in White participants. The low, overall prevalence may reflect the success of shelter-in-place mandates at the time this study was performed and of maintaining effective physical distancing practices among suburban populations. Under these public health measures and aggressive case finding, outbreak clusters did not spread into the general population.Amir BarzinJohn L. SchmitzSamuel RosinRameet SirpalMartha AlmondCarole RobinetteSamantha WellsMichael HudgensAndrew OlshanStephanie DeenPatrick KrejciEugenia QuackenbushKevin ChronowskiCaleb CornabyJanette GoinsLinda ButlerJulia AucoinKim BoyerJanet FaulkDevena Alston-JohnsonCristen PageYijun ZhouLynne FiscusBlossom DamaniaDirk P. DittmerDavid B. PedenAmerican Society for MicrobiologyarticleCOVID-19SARS-CoV-2antibodycoronavirusseroprevalenceMicrobiologyQR1-502ENmBio, Vol 11, Iss 5 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
COVID-19 SARS-CoV-2 antibody coronavirus seroprevalence Microbiology QR1-502 |
| spellingShingle |
COVID-19 SARS-CoV-2 antibody coronavirus seroprevalence Microbiology QR1-502 Amir Barzin John L. Schmitz Samuel Rosin Rameet Sirpal Martha Almond Carole Robinette Samantha Wells Michael Hudgens Andrew Olshan Stephanie Deen Patrick Krejci Eugenia Quackenbush Kevin Chronowski Caleb Cornaby Janette Goins Linda Butler Julia Aucoin Kim Boyer Janet Faulk Devena Alston-Johnson Cristen Page Yijun Zhou Lynne Fiscus Blossom Damania Dirk P. Dittmer David B. Peden SARS-CoV-2 Seroprevalence among a Southern U.S. Population Indicates Limited Asymptomatic Spread under Physical Distancing Measures |
| description |
ABSTRACT Characterizing the asymptomatic spread of SARS-CoV-2 is important for understanding the COVID-19 pandemic. This study was aimed at determining asymptomatic spread of SARS-CoV-2 in a suburban, Southern U.S. population during a period of state restrictions and physical distancing mandates. This is one of the first published seroprevalence studies from North Carolina and included multicenter, primary care, and emergency care facilities serving a low-density, suburban and rural population since description of the North Carolina state index case introducing the SARS-CoV-2 respiratory pathogen to this population. To estimate point seroprevalence of SARS-CoV-2 among asymptomatic individuals over time, two cohort studies were examined. The first cohort study, named ScreenNC, was comprised of outpatient clinics, and the second cohort study, named ScreenNC2, was comprised of inpatients unrelated to COVID-19. Asymptomatic infection by SARS-CoV-2 (with no clinical symptoms) was examined using an Emergency Use Authorization (EUA)-approved antibody test (Abbott) for the presence of SARS-CoV-2 IgG. This assay as performed under CLIA had a reported specificity/sensitivity of 100%/99.6%. ScreenNC identified 24 out of 2,973 (0.8%) positive individuals among asymptomatic participants accessing health care during 28 April to 19 June 2020, which was increasing over time. A separate cohort, ScreenNC2, sampled from 3 March to 4 June 2020, identified 10 out of 1,449 (0.7%) positive participants. IMPORTANCE This study suggests limited but accelerating asymptomatic spread of SARS-CoV-2. Asymptomatic infections, like symptomatic infections, disproportionately affected vulnerable communities in this population, and seroprevalence was higher in African American participants than in White participants. The low, overall prevalence may reflect the success of shelter-in-place mandates at the time this study was performed and of maintaining effective physical distancing practices among suburban populations. Under these public health measures and aggressive case finding, outbreak clusters did not spread into the general population. |
| format |
article |
| author |
Amir Barzin John L. Schmitz Samuel Rosin Rameet Sirpal Martha Almond Carole Robinette Samantha Wells Michael Hudgens Andrew Olshan Stephanie Deen Patrick Krejci Eugenia Quackenbush Kevin Chronowski Caleb Cornaby Janette Goins Linda Butler Julia Aucoin Kim Boyer Janet Faulk Devena Alston-Johnson Cristen Page Yijun Zhou Lynne Fiscus Blossom Damania Dirk P. Dittmer David B. Peden |
| author_facet |
Amir Barzin John L. Schmitz Samuel Rosin Rameet Sirpal Martha Almond Carole Robinette Samantha Wells Michael Hudgens Andrew Olshan Stephanie Deen Patrick Krejci Eugenia Quackenbush Kevin Chronowski Caleb Cornaby Janette Goins Linda Butler Julia Aucoin Kim Boyer Janet Faulk Devena Alston-Johnson Cristen Page Yijun Zhou Lynne Fiscus Blossom Damania Dirk P. Dittmer David B. Peden |
| author_sort |
Amir Barzin |
| title |
SARS-CoV-2 Seroprevalence among a Southern U.S. Population Indicates Limited Asymptomatic Spread under Physical Distancing Measures |
| title_short |
SARS-CoV-2 Seroprevalence among a Southern U.S. Population Indicates Limited Asymptomatic Spread under Physical Distancing Measures |
| title_full |
SARS-CoV-2 Seroprevalence among a Southern U.S. Population Indicates Limited Asymptomatic Spread under Physical Distancing Measures |
| title_fullStr |
SARS-CoV-2 Seroprevalence among a Southern U.S. Population Indicates Limited Asymptomatic Spread under Physical Distancing Measures |
| title_full_unstemmed |
SARS-CoV-2 Seroprevalence among a Southern U.S. Population Indicates Limited Asymptomatic Spread under Physical Distancing Measures |
| title_sort |
sars-cov-2 seroprevalence among a southern u.s. population indicates limited asymptomatic spread under physical distancing measures |
| publisher |
American Society for Microbiology |
| publishDate |
2020 |
| url |
https://doaj.org/article/fc1d5c1e83274491868c6782f4af6c9d |
| work_keys_str_mv |
AT amirbarzin sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT johnlschmitz sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT samuelrosin sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT rameetsirpal sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT marthaalmond sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT carolerobinette sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT samanthawells sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT michaelhudgens sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT andrewolshan sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT stephaniedeen sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT patrickkrejci sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT eugeniaquackenbush sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT kevinchronowski sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT calebcornaby sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT janettegoins sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT lindabutler sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT juliaaucoin sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT kimboyer sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT janetfaulk sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT devenaalstonjohnson sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT cristenpage sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT yijunzhou sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT lynnefiscus sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT blossomdamania sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT dirkpdittmer sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures AT davidbpeden sarscov2seroprevalenceamongasouthernuspopulationindicateslimitedasymptomaticspreadunderphysicaldistancingmeasures |
| _version_ |
1718427006118395904 |