Flow Injection–Indirect Spectrophotometry for Hydroquinone Analysis Based on the Formation of Iron(II)-Phenanthroline Complex

Hydroquinone is an organic antioxidant widely used for skin lightening products which can cause negative impact in excessive use. This study is focused on the development of fast method for the determination of hydroquinone using flow injection-indirect spectrophotometry based on the formation of re...

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Autores principales:	Mariam Mohamed Omar Alshibani, Hermin Sulistyarti, Akhmad Sabarudin
Formato:	article
Lenguaje:	EN
Publicado:	University of Brawijaya 2019
Materias:	hydroquinone flow injection spectrophotometry iron phenanthroline Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/fc20333e6a4e45f1b9d732ac8e31cf1d
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spelling	oai:doaj.org-article:fc20333e6a4e45f1b9d732ac8e31cf1d2021-12-02T18:05:07ZFlow Injection–Indirect Spectrophotometry for Hydroquinone Analysis Based on the Formation of Iron(II)-Phenanthroline Complex2302-46902302-4690https://doaj.org/article/fc20333e6a4e45f1b9d732ac8e31cf1d2019-10-01T00:00:00Zhttps://jpacr.ub.ac.id/index.php/jpacr/article/view/478/pdfhttps://doaj.org/toc/2302-4690https://doaj.org/toc/2302-4690Hydroquinone is an organic antioxidant widely used for skin lightening products which can cause negative impact in excessive use. This study is focused on the development of fast method for the determination of hydroquinone using flow injection-indirect spectrophotometry based on the formation of red complex Iron(II)-phenanthroline. In this method, hydroquinone reduced iron(III) to iron(II) which in the presence of phenanthroline formed Iron(II)-phenanthroline complex detected at maximum wavelength of 510 nm. The common operational and chemical conditions were optimized and the effect of several interfering compounds was also studied to achieve the highest sensitivity with acceptable analysis time. The optimum method performance was obtained under the conditions of 100 µL sample volume, 50 cm mixing coil-1and 75 cm mixing coil-2, 5 ml/min flow rate, 100 mgL-1 Iron(III) concentration, and 0.15 % phenanthroline. Under these conditions the proposed FI-spectrophotometry gave results to linear calibration over the concentration range from 2-100 mgL-1 (y = 0.028x and R2 of 0.999). The method was not interfered in the presence of vitamin C 1 mgL-1 and resorcinol up to 10 mgL-1. However, the higher concentration of vitamin C ³10 ppm and resorcinol ³ 20 ppm gave significant error of measurements. Method validation using standard additions gave results to average recovery value of 97.02 %, which indicates that the FI-spectrophotometry method can be used as an alternative method for determining hydroquinone in cosmetic.Mariam Mohamed Omar AlshibaniHermin SulistyartiAkhmad SabarudinUniversity of Brawijayaarticlehydroquinoneflow injectionspectrophotometryironphenanthrolineChemistryQD1-999ENJournal of Pure and Applied Chemistry Research, Vol 8, Iss 3, Pp 208-216 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	hydroquinone flow injection spectrophotometry iron phenanthroline Chemistry QD1-999
spellingShingle	hydroquinone flow injection spectrophotometry iron phenanthroline Chemistry QD1-999 Mariam Mohamed Omar Alshibani Hermin Sulistyarti Akhmad Sabarudin Flow Injection–Indirect Spectrophotometry for Hydroquinone Analysis Based on the Formation of Iron(II)-Phenanthroline Complex
description	Hydroquinone is an organic antioxidant widely used for skin lightening products which can cause negative impact in excessive use. This study is focused on the development of fast method for the determination of hydroquinone using flow injection-indirect spectrophotometry based on the formation of red complex Iron(II)-phenanthroline. In this method, hydroquinone reduced iron(III) to iron(II) which in the presence of phenanthroline formed Iron(II)-phenanthroline complex detected at maximum wavelength of 510 nm. The common operational and chemical conditions were optimized and the effect of several interfering compounds was also studied to achieve the highest sensitivity with acceptable analysis time. The optimum method performance was obtained under the conditions of 100 µL sample volume, 50 cm mixing coil-1and 75 cm mixing coil-2, 5 ml/min flow rate, 100 mgL-1 Iron(III) concentration, and 0.15 % phenanthroline. Under these conditions the proposed FI-spectrophotometry gave results to linear calibration over the concentration range from 2-100 mgL-1 (y = 0.028x and R2 of 0.999). The method was not interfered in the presence of vitamin C 1 mgL-1 and resorcinol up to 10 mgL-1. However, the higher concentration of vitamin C ³10 ppm and resorcinol ³ 20 ppm gave significant error of measurements. Method validation using standard additions gave results to average recovery value of 97.02 %, which indicates that the FI-spectrophotometry method can be used as an alternative method for determining hydroquinone in cosmetic.
format	article
author	Mariam Mohamed Omar Alshibani Hermin Sulistyarti Akhmad Sabarudin
author_facet	Mariam Mohamed Omar Alshibani Hermin Sulistyarti Akhmad Sabarudin
author_sort	Mariam Mohamed Omar Alshibani
title	Flow Injection–Indirect Spectrophotometry for Hydroquinone Analysis Based on the Formation of Iron(II)-Phenanthroline Complex
title_short	Flow Injection–Indirect Spectrophotometry for Hydroquinone Analysis Based on the Formation of Iron(II)-Phenanthroline Complex
title_full	Flow Injection–Indirect Spectrophotometry for Hydroquinone Analysis Based on the Formation of Iron(II)-Phenanthroline Complex
title_fullStr	Flow Injection–Indirect Spectrophotometry for Hydroquinone Analysis Based on the Formation of Iron(II)-Phenanthroline Complex
title_full_unstemmed	Flow Injection–Indirect Spectrophotometry for Hydroquinone Analysis Based on the Formation of Iron(II)-Phenanthroline Complex
title_sort	flow injection–indirect spectrophotometry for hydroquinone analysis based on the formation of iron(ii)-phenanthroline complex
publisher	University of Brawijaya
publishDate	2019
url	https://doaj.org/article/fc20333e6a4e45f1b9d732ac8e31cf1d
work_keys_str_mv	AT mariammohamedomaralshibani flowinjectionindirectspectrophotometryforhydroquinoneanalysisbasedontheformationofironiiphenanthrolinecomplex AT herminsulistyarti flowinjectionindirectspectrophotometryforhydroquinoneanalysisbasedontheformationofironiiphenanthrolinecomplex AT akhmadsabarudin flowinjectionindirectspectrophotometryforhydroquinoneanalysisbasedontheformationofironiiphenanthrolinecomplex
_version_	1718378726998147072

Flow Injection–Indirect Spectrophotometry for Hydroquinone Analysis Based on the Formation of Iron(II)-Phenanthroline Complex

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