Complexity and wide range of neuromyelitis optica spectrum disorders: more than typical manifestations

Jinming Han,1 Meng-ge Yang,1 Jie Zhu,1,2 Tao Jin1 1Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China; 2Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden Abstract: Neuromyelitis optica (NMO), consid...

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Autores principales:	Han J, Yang M, Zhu J, Jin T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Neuromyelitis optica spectrum disorders (NMOSD) anti-aquaporin-4 antibody comorbid conditions atypical manifestations. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/fc20419c31d940e9b7c2e6482171f444
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spelling	oai:doaj.org-article:fc20419c31d940e9b7c2e6482171f4442021-12-02T00:57:19ZComplexity and wide range of neuromyelitis optica spectrum disorders: more than typical manifestations1178-2021https://doaj.org/article/fc20419c31d940e9b7c2e6482171f4442017-10-01T00:00:00Zhttps://www.dovepress.com/complexity-and-wide-range-of-neuromyelitis-optica-spectrum-disorders-m-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jinming Han,1 Meng-ge Yang,1 Jie Zhu,1,2 Tao Jin1 1Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China; 2Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden Abstract: Neuromyelitis optica (NMO), considered to be mediated by autoantibodies, often cause severely disabling disorders of the central nervous system, and predominantly cause optic nerve damage and longitudinally extensive transverse myelitis. Remarkable progress has been made in deciphering NMO pathogenesis during the past decade. In 2015, the International Panel for NMO Diagnosis proposed the unifying term “NMO spectrum disorders” (NMOSD) and the updated NMOSD criteria reflects a wide range of disease and maintains reasonable specificity. Moreover, cumulative findings have indicated that NMOSD are frequently associated with multiple autoimmune diseases, thereby presenting complex clinical symptoms that make this disease more difficult to recognize. Notably, most neurologists do not heed these symptoms or comorbid conditions in patients with NMOSD. Whereas previous reviews have focused on pathogenesis, treatment, and prognosis in NMOSD, we summarize the present knowledge with particular emphasis on atypical manifestations and autoimmune comorbidities in patients with NMOSD. Furthermore, we emphasized the identification of these atypical characteristics to enable a broader and better understanding of NMOSD, and improve early accurate diagnosis and therapeutic decision making. Keywords: neuromyelitis optica spectrum disorders, anti-aquaporin-4 antibody, comorbid conditions, atypical manifestationsHan JYang MZhu JJin TDove Medical PressarticleNeuromyelitis optica spectrum disorders (NMOSD)anti-aquaporin-4 antibodycomorbid conditionsatypical manifestations.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2653-2660 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neuromyelitis optica spectrum disorders (NMOSD) anti-aquaporin-4 antibody comorbid conditions atypical manifestations. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neuromyelitis optica spectrum disorders (NMOSD) anti-aquaporin-4 antibody comorbid conditions atypical manifestations. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Han J Yang M Zhu J Jin T Complexity and wide range of neuromyelitis optica spectrum disorders: more than typical manifestations
description	Jinming Han,1 Meng-ge Yang,1 Jie Zhu,1,2 Tao Jin1 1Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China; 2Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden Abstract: Neuromyelitis optica (NMO), considered to be mediated by autoantibodies, often cause severely disabling disorders of the central nervous system, and predominantly cause optic nerve damage and longitudinally extensive transverse myelitis. Remarkable progress has been made in deciphering NMO pathogenesis during the past decade. In 2015, the International Panel for NMO Diagnosis proposed the unifying term “NMO spectrum disorders” (NMOSD) and the updated NMOSD criteria reflects a wide range of disease and maintains reasonable specificity. Moreover, cumulative findings have indicated that NMOSD are frequently associated with multiple autoimmune diseases, thereby presenting complex clinical symptoms that make this disease more difficult to recognize. Notably, most neurologists do not heed these symptoms or comorbid conditions in patients with NMOSD. Whereas previous reviews have focused on pathogenesis, treatment, and prognosis in NMOSD, we summarize the present knowledge with particular emphasis on atypical manifestations and autoimmune comorbidities in patients with NMOSD. Furthermore, we emphasized the identification of these atypical characteristics to enable a broader and better understanding of NMOSD, and improve early accurate diagnosis and therapeutic decision making. Keywords: neuromyelitis optica spectrum disorders, anti-aquaporin-4 antibody, comorbid conditions, atypical manifestations
format	article
author	Han J Yang M Zhu J Jin T
author_facet	Han J Yang M Zhu J Jin T
author_sort	Han J
title	Complexity and wide range of neuromyelitis optica spectrum disorders: more than typical manifestations
title_short	Complexity and wide range of neuromyelitis optica spectrum disorders: more than typical manifestations
title_full	Complexity and wide range of neuromyelitis optica spectrum disorders: more than typical manifestations
title_fullStr	Complexity and wide range of neuromyelitis optica spectrum disorders: more than typical manifestations
title_full_unstemmed	Complexity and wide range of neuromyelitis optica spectrum disorders: more than typical manifestations
title_sort	complexity and wide range of neuromyelitis optica spectrum disorders: more than typical manifestations
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/fc20419c31d940e9b7c2e6482171f444
work_keys_str_mv	AT hanj complexityandwiderangeofneuromyelitisopticaspectrumdisordersmorethantypicalmanifestations AT yangm complexityandwiderangeofneuromyelitisopticaspectrumdisordersmorethantypicalmanifestations AT zhuj complexityandwiderangeofneuromyelitisopticaspectrumdisordersmorethantypicalmanifestations AT jint complexityandwiderangeofneuromyelitisopticaspectrumdisordersmorethantypicalmanifestations
_version_	1718403414659956736

Complexity and wide range of neuromyelitis optica spectrum disorders: more than typical manifestations

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