Activity of the upstream component of tandem TERT/survivin promoters depends on features of the downstream component.

Activity of the upstream component of tandem TERT/survivin promoters depends on features of the downstream component.

We spliced the promoters of the human telomerase and human survivin genes (PhTERT and PhSurv, respectively) widely used for gene therapy and known to have the broadest cancer type spectrum of activity. Two head-to-tail constructs were obtained: the PhTERT-PhSurv and PhSurv-PhTERT tandems. The splici...

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Autores principales: Irina V Alekseenko, Victor V Pleshkan, Eugene P Kopantzev, Elena A Stukacheva, Igor P Chernov, Tatyana V Vinogradova, Eugene D Sverdlov
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/fc252ac0142c49f6a02ce405beb181d2
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