A nested case–control study of risk for pulmonary embolism in the general trauma population using nationwide trauma registry data in Japan
Abstract Post-trauma patients are at great risk of pulmonary embolism (PE), however, data assessing specific risk factors for post-traumatic PE are scarce. This was a nested case–control study using the Japan Trauma Data Bank between 2004 and 2017. We enrolled patients aged ≥ 16 years, Injury Severi...
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Nature Portfolio
2021
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oai:doaj.org-article:fc2a1ed13fec4462a7ce368c3f5db9d12021-12-02T17:37:28ZA nested case–control study of risk for pulmonary embolism in the general trauma population using nationwide trauma registry data in Japan10.1038/s41598-021-98692-42045-2322https://doaj.org/article/fc2a1ed13fec4462a7ce368c3f5db9d12021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98692-4https://doaj.org/toc/2045-2322Abstract Post-trauma patients are at great risk of pulmonary embolism (PE), however, data assessing specific risk factors for post-traumatic PE are scarce. This was a nested case–control study using the Japan Trauma Data Bank between 2004 and 2017. We enrolled patients aged ≥ 16 years, Injury Severity Score ≥ 9, and length of hospital stay ≥ 2 days, with PE and without PE, using propensity score matching. We conducted logistic regression analyses to examine risk factors for PE. We included 719 patients with PE and 3595 patients without PE. Of these patients, 1864 [43.2%] were male, and their median Interquartile Range (IQR) age was 73 [55–84] years. The major mechanism of injury was blunt (4282 [99.3%]). Median [IQR] Injury Severity Score (ISS) was 10 [9–18]. In the multivariate analysis, the variables spinal injury [odds ratio (OR), 1.40 (1.03–1.89)]; long bone open fracture in upper extremity and lower extremity [OR, 1.51 (1.06–2.15) and OR, 3.69 (2.89–4.71), respectively]; central vein catheter [OR, 2.17 (1.44–3.27)]; and any surgery [OR, 4.48 (3.46–5.81)] were independently associated with PE. Spinal injury, long bone open fracture in extremities, central vein catheter placement, and any surgery were risk factors for post-traumatic PE. Prompt initiation of prophylaxis is needed for patients with such trauma.Hiroki IriyamaAkira KomoriTakako KainohYutaka KondoToshio NaitoToshikazu AbeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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Medicine R Science Q Hiroki Iriyama Akira Komori Takako Kainoh Yutaka Kondo Toshio Naito Toshikazu Abe A nested case–control study of risk for pulmonary embolism in the general trauma population using nationwide trauma registry data in Japan |
| description |
Abstract Post-trauma patients are at great risk of pulmonary embolism (PE), however, data assessing specific risk factors for post-traumatic PE are scarce. This was a nested case–control study using the Japan Trauma Data Bank between 2004 and 2017. We enrolled patients aged ≥ 16 years, Injury Severity Score ≥ 9, and length of hospital stay ≥ 2 days, with PE and without PE, using propensity score matching. We conducted logistic regression analyses to examine risk factors for PE. We included 719 patients with PE and 3595 patients without PE. Of these patients, 1864 [43.2%] were male, and their median Interquartile Range (IQR) age was 73 [55–84] years. The major mechanism of injury was blunt (4282 [99.3%]). Median [IQR] Injury Severity Score (ISS) was 10 [9–18]. In the multivariate analysis, the variables spinal injury [odds ratio (OR), 1.40 (1.03–1.89)]; long bone open fracture in upper extremity and lower extremity [OR, 1.51 (1.06–2.15) and OR, 3.69 (2.89–4.71), respectively]; central vein catheter [OR, 2.17 (1.44–3.27)]; and any surgery [OR, 4.48 (3.46–5.81)] were independently associated with PE. Spinal injury, long bone open fracture in extremities, central vein catheter placement, and any surgery were risk factors for post-traumatic PE. Prompt initiation of prophylaxis is needed for patients with such trauma. |
| format |
article |
| author |
Hiroki Iriyama Akira Komori Takako Kainoh Yutaka Kondo Toshio Naito Toshikazu Abe |
| author_facet |
Hiroki Iriyama Akira Komori Takako Kainoh Yutaka Kondo Toshio Naito Toshikazu Abe |
| author_sort |
Hiroki Iriyama |
| title |
A nested case–control study of risk for pulmonary embolism in the general trauma population using nationwide trauma registry data in Japan |
| title_short |
A nested case–control study of risk for pulmonary embolism in the general trauma population using nationwide trauma registry data in Japan |
| title_full |
A nested case–control study of risk for pulmonary embolism in the general trauma population using nationwide trauma registry data in Japan |
| title_fullStr |
A nested case–control study of risk for pulmonary embolism in the general trauma population using nationwide trauma registry data in Japan |
| title_full_unstemmed |
A nested case–control study of risk for pulmonary embolism in the general trauma population using nationwide trauma registry data in Japan |
| title_sort |
nested case–control study of risk for pulmonary embolism in the general trauma population using nationwide trauma registry data in japan |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/fc2a1ed13fec4462a7ce368c3f5db9d1 |
| work_keys_str_mv |
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1718379919116861440 |