<i>NR3C1</i> Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies

Glomerular diseases (GNs) are responsible for approximately 20% of chronic kidney diseases. Glucocorticoid receptor gene (<i>NR3C1</i>) single nucleotide polymorphisms (SNPs) are implicated in differences in predisposition to autoimmunity and steroid sensitivity. The aim of this study wa...

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Autores principales:	Michał Pac, Natalia Krata, Barbara Moszczuk, Aleksandra Wyczałkowska-Tomasik, Beata Kaleta, Bartosz Foroncewicz, Witold Rudnicki, Leszek Pączek, Krzysztof Mucha
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	genomics glucocorticoid receptor IgA nephropathy membranous nephropathy single nucleotide polymorphism Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/fc344cdf1a3d439d882e7ba6bc08a608
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spelling	oai:doaj.org-article:fc344cdf1a3d439d882e7ba6bc08a6082021-11-25T17:12:34Z<i>NR3C1</i> Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies10.3390/cells101131862073-4409https://doaj.org/article/fc344cdf1a3d439d882e7ba6bc08a6082021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3186https://doaj.org/toc/2073-4409Glomerular diseases (GNs) are responsible for approximately 20% of chronic kidney diseases. Glucocorticoid receptor gene (<i>NR3C1</i>) single nucleotide polymorphisms (SNPs) are implicated in differences in predisposition to autoimmunity and steroid sensitivity. The aim of this study was to evaluate the frequency of the <i>NR3C1</i> SNPs—rs6198, rs41423247 and rs17209237—in 72 IgA nephropathy (IgAN) and 38 membranous nephropathy (MN) patients compared to 175 healthy controls and to correlate the effectiveness of treatment in IgAN and MN groups defined as a reduction of proteinuria <1 g/24 h after 12 months of treatment. Real-time polymerase chain reactions and SNP array-based typing were used. We found significant rs41423247 association with MN (<i>p</i> = 0.026); a significant association of rs17209237 with eGFR reduction after follow-up period in all patients with GNs (<i>p</i> = 0.021) and with the degree of proteinuria after 1 year of therapy in all patients with a glomerulopathy (<i>p</i> = 0.013) and IgAN (<i>p</i> = 0.021); and in the same groups treated with steroids (<i>p</i> = 0.021; <i>p</i> = 0.012). We also observed the association between rs41423247 and IgAN histopathologic findings (<i>p</i> = 0.012). In conclusion, our results indicate that <i>NR3C1</i> polymorphisms may influence treatment susceptibility and clinical outcome in IgAN and MN.Michał PacNatalia KrataBarbara MoszczukAleksandra Wyczałkowska-TomasikBeata KaletaBartosz ForoncewiczWitold RudnickiLeszek PączekKrzysztof MuchaMDPI AGarticlegenomicsglucocorticoid receptorIgA nephropathymembranous nephropathysingle nucleotide polymorphismBiology (General)QH301-705.5ENCells, Vol 10, Iss 3186, p 3186 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	genomics glucocorticoid receptor IgA nephropathy membranous nephropathy single nucleotide polymorphism Biology (General) QH301-705.5
spellingShingle	genomics glucocorticoid receptor IgA nephropathy membranous nephropathy single nucleotide polymorphism Biology (General) QH301-705.5 Michał Pac Natalia Krata Barbara Moszczuk Aleksandra Wyczałkowska-Tomasik Beata Kaleta Bartosz Foroncewicz Witold Rudnicki Leszek Pączek Krzysztof Mucha <i>NR3C1</i> Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies
description	Glomerular diseases (GNs) are responsible for approximately 20% of chronic kidney diseases. Glucocorticoid receptor gene (<i>NR3C1</i>) single nucleotide polymorphisms (SNPs) are implicated in differences in predisposition to autoimmunity and steroid sensitivity. The aim of this study was to evaluate the frequency of the <i>NR3C1</i> SNPs—rs6198, rs41423247 and rs17209237—in 72 IgA nephropathy (IgAN) and 38 membranous nephropathy (MN) patients compared to 175 healthy controls and to correlate the effectiveness of treatment in IgAN and MN groups defined as a reduction of proteinuria <1 g/24 h after 12 months of treatment. Real-time polymerase chain reactions and SNP array-based typing were used. We found significant rs41423247 association with MN (<i>p</i> = 0.026); a significant association of rs17209237 with eGFR reduction after follow-up period in all patients with GNs (<i>p</i> = 0.021) and with the degree of proteinuria after 1 year of therapy in all patients with a glomerulopathy (<i>p</i> = 0.013) and IgAN (<i>p</i> = 0.021); and in the same groups treated with steroids (<i>p</i> = 0.021; <i>p</i> = 0.012). We also observed the association between rs41423247 and IgAN histopathologic findings (<i>p</i> = 0.012). In conclusion, our results indicate that <i>NR3C1</i> polymorphisms may influence treatment susceptibility and clinical outcome in IgAN and MN.
format	article
author	Michał Pac Natalia Krata Barbara Moszczuk Aleksandra Wyczałkowska-Tomasik Beata Kaleta Bartosz Foroncewicz Witold Rudnicki Leszek Pączek Krzysztof Mucha
author_facet	Michał Pac Natalia Krata Barbara Moszczuk Aleksandra Wyczałkowska-Tomasik Beata Kaleta Bartosz Foroncewicz Witold Rudnicki Leszek Pączek Krzysztof Mucha
author_sort	Michał Pac
title	<i>NR3C1</i> Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies
title_short	<i>NR3C1</i> Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies
title_full	<i>NR3C1</i> Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies
title_fullStr	<i>NR3C1</i> Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies
title_full_unstemmed	<i>NR3C1</i> Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies
title_sort	<i>nr3c1</i> glucocorticoid receptor gene polymorphisms are associated with membranous and iga nephropathies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fc344cdf1a3d439d882e7ba6bc08a608
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<i>NR3C1</i> Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies

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