Differences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients

Abstract In developing countries, breast cancer is diagnosed at a much younger age. In this study we investigate the dichotomies between older and young breast cancer patients in our region. The study involved two cohorts; older patients (≥ 65 years, n = 553) and younger ones (≤ 40 years, n = 417)....

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Autores principales:	Hikmat Abdel-Razeq, Sereen Iweir, Rashid Abdel-Razeq, Fadwa Abdel Rahman, Hanan Almasri, Rayan Bater, Ayat Taqash, Hadeel Abdelkhaleq
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fc3478d9616c411cb330786c70704c46
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spelling	oai:doaj.org-article:fc3478d9616c411cb330786c70704c462021-12-02T18:30:57ZDifferences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients10.1038/s41598-021-93676-w2045-2322https://doaj.org/article/fc3478d9616c411cb330786c70704c462021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93676-whttps://doaj.org/toc/2045-2322Abstract In developing countries, breast cancer is diagnosed at a much younger age. In this study we investigate the dichotomies between older and young breast cancer patients in our region. The study involved two cohorts; older patients (≥ 65 years, n = 553) and younger ones (≤ 40 years, n = 417). Statistical models were used to investigate the associations between age groups, clinical characteristics and treatment outcomes. Compared to younger patients, older patients were more likely to present with advanced-stage disease (20.6% vs. 15.1%, p = .028). However, among those with non-metastatic disease, younger patients tended to have more aggressive pathological features, including positive axillary lymph nodes (73.2% vs. 55.6%, p < .001), T-3/4 (28.2% vs. 13.8%, p < .001) and HER2-positive disease (29.3% vs. 16.3%, p < .001). The 5-year overall survival (OS) rate was significantly better for the younger (72.1%) compared to the older (67.6%), p = .035. However, no significant difference was observed in disease-free survival (DFS) between the two groups.In conclusion, younger patients with breast cancer present with worse clinical and pathological features, albeit a better OS rate. The difference in DFS between the two groups was not insignificant, suggesting that older women were more likely to die from non-cancer related causes.Hikmat Abdel-RazeqSereen IweirRashid Abdel-RazeqFadwa Abdel RahmanHanan AlmasriRayan BaterAyat TaqashHadeel AbdelkhaleqNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hikmat Abdel-Razeq Sereen Iweir Rashid Abdel-Razeq Fadwa Abdel Rahman Hanan Almasri Rayan Bater Ayat Taqash Hadeel Abdelkhaleq Differences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients
description	Abstract In developing countries, breast cancer is diagnosed at a much younger age. In this study we investigate the dichotomies between older and young breast cancer patients in our region. The study involved two cohorts; older patients (≥ 65 years, n = 553) and younger ones (≤ 40 years, n = 417). Statistical models were used to investigate the associations between age groups, clinical characteristics and treatment outcomes. Compared to younger patients, older patients were more likely to present with advanced-stage disease (20.6% vs. 15.1%, p = .028). However, among those with non-metastatic disease, younger patients tended to have more aggressive pathological features, including positive axillary lymph nodes (73.2% vs. 55.6%, p < .001), T-3/4 (28.2% vs. 13.8%, p < .001) and HER2-positive disease (29.3% vs. 16.3%, p < .001). The 5-year overall survival (OS) rate was significantly better for the younger (72.1%) compared to the older (67.6%), p = .035. However, no significant difference was observed in disease-free survival (DFS) between the two groups.In conclusion, younger patients with breast cancer present with worse clinical and pathological features, albeit a better OS rate. The difference in DFS between the two groups was not insignificant, suggesting that older women were more likely to die from non-cancer related causes.
format	article
author	Hikmat Abdel-Razeq Sereen Iweir Rashid Abdel-Razeq Fadwa Abdel Rahman Hanan Almasri Rayan Bater Ayat Taqash Hadeel Abdelkhaleq
author_facet	Hikmat Abdel-Razeq Sereen Iweir Rashid Abdel-Razeq Fadwa Abdel Rahman Hanan Almasri Rayan Bater Ayat Taqash Hadeel Abdelkhaleq
author_sort	Hikmat Abdel-Razeq
title	Differences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients
title_short	Differences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients
title_full	Differences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients
title_fullStr	Differences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients
title_full_unstemmed	Differences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients
title_sort	differences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fc3478d9616c411cb330786c70704c46
work_keys_str_mv	AT hikmatabdelrazeq differencesinclinicopathologicalcharacteristicstreatmentandsurvivaloutcomesbetweenolderandyoungerbreastcancerpatients AT sereeniweir differencesinclinicopathologicalcharacteristicstreatmentandsurvivaloutcomesbetweenolderandyoungerbreastcancerpatients AT rashidabdelrazeq differencesinclinicopathologicalcharacteristicstreatmentandsurvivaloutcomesbetweenolderandyoungerbreastcancerpatients AT fadwaabdelrahman differencesinclinicopathologicalcharacteristicstreatmentandsurvivaloutcomesbetweenolderandyoungerbreastcancerpatients AT hananalmasri differencesinclinicopathologicalcharacteristicstreatmentandsurvivaloutcomesbetweenolderandyoungerbreastcancerpatients AT rayanbater differencesinclinicopathologicalcharacteristicstreatmentandsurvivaloutcomesbetweenolderandyoungerbreastcancerpatients AT ayattaqash differencesinclinicopathologicalcharacteristicstreatmentandsurvivaloutcomesbetweenolderandyoungerbreastcancerpatients AT hadeelabdelkhaleq differencesinclinicopathologicalcharacteristicstreatmentandsurvivaloutcomesbetweenolderandyoungerbreastcancerpatients
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Differences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients

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