Hantaviruses use the endogenous host factor P58IPK to combat the PKR antiviral response.
Hantavirus nucleocapsid protein (NP) inhibits protein kinase R (PKR) dimerization by an unknown mechanism to counteract its antiviral responses during virus infection. Here we demonstrate that NP exploits an endogenous PKR inhibitor P58IPK to inhibit PKR. The activity of P58IPK is normally restricte...
Guardado en:
Autores principales: | Zekun Wang, Songyang Ren, Qiming Li, Austin D Royster, Lei Lin, Sichen Liu, Safder S Ganaie, Jianming Qiu, Sheema Mir, Mohammad A Mir |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/fc347b4fe5674dde86684e65fbe767f4 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
A novel approach for the purification of aggregation prone proteins.
por: Austin Royster, et al.
Publicado: (2021) -
Interaction of PKR with single-stranded RNA
por: Christopher B. Mayo, et al.
Publicado: (2017) -
Towards antiviral polymer composites to combat COVID‐19 transmission
por: Adrian P. Mouritz, et al.
Publicado: (2021) -
Development of antiviral therapeutics combating coxsackievirus type B3 infection
por: A. S. Volobueva, et al.
Publicado: (2021) -
Acta No. 58
por: Banco Central de Chile
Publicado: (2019)