Wastewater-powered high-value chemical synthesis in a hybrid bioelectrochemical system

Summary: A microbial electrochemical system could potentially be applied as a biosynthesis platform by extracting wastewater energy while converting it to value-added chemicals. However, the unfavorable thermodynamics and sluggish kinetics of in vivo whole-cell cathodic catalysis largely limit produ...

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Autores principales:	Ranran Wu, Yang-Yang Yu, Yuanming Wang, Yan-Zhai Wang, Haiyan Song, Chunling Ma, Ge Qu, Chun You, Zhoutong Sun, Wuyuan Zhang, Aitao Li, Chang Ming Li, Yang-Chun Yong, Zhiguang Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Materials in biotechnology Materials science Electrochemistry Bio-electrochemistry Science Q
Acceso en línea:	https://doaj.org/article/fc3c2316496b4ba9aac787f9b459bd6a
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spelling	oai:doaj.org-article:fc3c2316496b4ba9aac787f9b459bd6a2021-11-20T05:11:14ZWastewater-powered high-value chemical synthesis in a hybrid bioelectrochemical system2589-004210.1016/j.isci.2021.103401https://doaj.org/article/fc3c2316496b4ba9aac787f9b459bd6a2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221013729https://doaj.org/toc/2589-0042Summary: A microbial electrochemical system could potentially be applied as a biosynthesis platform by extracting wastewater energy while converting it to value-added chemicals. However, the unfavorable thermodynamics and sluggish kinetics of in vivo whole-cell cathodic catalysis largely limit product diversity and value. Herein, we convert the in vivo cathodic reaction to in vitro enzymatic catalysis and develop a microbe-enzyme hybrid bioelectrochemical system (BES), where microbes release the electricity from wastewater (anode) to power enzymatic catalysis (cathode). Three representative examples for the synthesis of pharmaceutically relevant compounds, including halofunctionalized oleic acid based on a cascade reaction, (4-chlorophenyl)-(pyridin-2-yl)-methanol based on electrochemical cofactor regeneration, and l-3,4-dihydroxyphenylalanine based on electrochemical reduction, were demonstrated. According to the techno-economic analysis, this system could deliver high system profit, opening an avenue to a potentially viable wastewater-to-profit process while shedding scientific light on hybrid BES mechanisms toward a sustainable reuse of wastewater.Ranran WuYang-Yang YuYuanming WangYan-Zhai WangHaiyan SongChunling MaGe QuChun YouZhoutong SunWuyuan ZhangAitao LiChang Ming LiYang-Chun YongZhiguang ZhuElsevierarticleMaterials in biotechnologyMaterials scienceElectrochemistryBio-electrochemistryScienceQENiScience, Vol 24, Iss 12, Pp 103401- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Materials in biotechnology Materials science Electrochemistry Bio-electrochemistry Science Q
spellingShingle	Materials in biotechnology Materials science Electrochemistry Bio-electrochemistry Science Q Ranran Wu Yang-Yang Yu Yuanming Wang Yan-Zhai Wang Haiyan Song Chunling Ma Ge Qu Chun You Zhoutong Sun Wuyuan Zhang Aitao Li Chang Ming Li Yang-Chun Yong Zhiguang Zhu Wastewater-powered high-value chemical synthesis in a hybrid bioelectrochemical system
description	Summary: A microbial electrochemical system could potentially be applied as a biosynthesis platform by extracting wastewater energy while converting it to value-added chemicals. However, the unfavorable thermodynamics and sluggish kinetics of in vivo whole-cell cathodic catalysis largely limit product diversity and value. Herein, we convert the in vivo cathodic reaction to in vitro enzymatic catalysis and develop a microbe-enzyme hybrid bioelectrochemical system (BES), where microbes release the electricity from wastewater (anode) to power enzymatic catalysis (cathode). Three representative examples for the synthesis of pharmaceutically relevant compounds, including halofunctionalized oleic acid based on a cascade reaction, (4-chlorophenyl)-(pyridin-2-yl)-methanol based on electrochemical cofactor regeneration, and l-3,4-dihydroxyphenylalanine based on electrochemical reduction, were demonstrated. According to the techno-economic analysis, this system could deliver high system profit, opening an avenue to a potentially viable wastewater-to-profit process while shedding scientific light on hybrid BES mechanisms toward a sustainable reuse of wastewater.
format	article
author	Ranran Wu Yang-Yang Yu Yuanming Wang Yan-Zhai Wang Haiyan Song Chunling Ma Ge Qu Chun You Zhoutong Sun Wuyuan Zhang Aitao Li Chang Ming Li Yang-Chun Yong Zhiguang Zhu
author_facet	Ranran Wu Yang-Yang Yu Yuanming Wang Yan-Zhai Wang Haiyan Song Chunling Ma Ge Qu Chun You Zhoutong Sun Wuyuan Zhang Aitao Li Chang Ming Li Yang-Chun Yong Zhiguang Zhu
author_sort	Ranran Wu
title	Wastewater-powered high-value chemical synthesis in a hybrid bioelectrochemical system
title_short	Wastewater-powered high-value chemical synthesis in a hybrid bioelectrochemical system
title_full	Wastewater-powered high-value chemical synthesis in a hybrid bioelectrochemical system
title_fullStr	Wastewater-powered high-value chemical synthesis in a hybrid bioelectrochemical system
title_full_unstemmed	Wastewater-powered high-value chemical synthesis in a hybrid bioelectrochemical system
title_sort	wastewater-powered high-value chemical synthesis in a hybrid bioelectrochemical system
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/fc3c2316496b4ba9aac787f9b459bd6a
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Wastewater-powered high-value chemical synthesis in a hybrid bioelectrochemical system

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