VARIATIONS IN CLINICAL PRESENTATION, NEUROIMAGING AND EEG PATTERNS OF SUBACUTE SCLEROSING PANENCEPHALITIS

Objective: To determine the variations in clinical presentation, neuroimaging and electroencephalography patterns of subacute sclerosing panencephalitis. Study Design: Cross-sectional study. Place and Duration of Study: Children’s Hospital & Institute of Child Health, Lahore, Pakistan, fro...

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Autores principales:	Areeba Wasim, Javeria Raza Alvi, Natasha Ghani, Athar Khalily, Zia Ur Rehman, Tipu Sultan
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	anti-measles antibodies electroencephalography Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fc413ed182944158b08e2bb06da7f53f
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spelling	oai:doaj.org-article:fc413ed182944158b08e2bb06da7f53f2021-11-24T04:20:11ZVARIATIONS IN CLINICAL PRESENTATION, NEUROIMAGING AND EEG PATTERNS OF SUBACUTE SCLEROSING PANENCEPHALITIS0030-96482411-8842https://doaj.org/article/fc413ed182944158b08e2bb06da7f53f2021-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/6669/3633https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the variations in clinical presentation, neuroimaging and electroencephalography patterns of subacute sclerosing panencephalitis. Study Design: Cross-sectional study. Place and Duration of Study: Children’s Hospital & Institute of Child Health, Lahore, Pakistan, from Jul to Dec 2020. Methodology: We recruited children presented with clinical features suggestive of subacute sclerosing panencephalitis, along with positive anti-measles antibodies on cerebrospinal fluid. Association between variables was determined to formulate an early diagnosis of subacute sclerosing panencephalitis. Results: Out of 47 children, 29 were males with a mean age of 6.54 ± 2.9 years. Only 23% were fully immunized against measles, 36.2% were unvaccinated and 40.4% received partial immunization. The mean age of measles infection was 1.49 ± 1.2 years; the mean interval between measles and onset of SSPE was 4.13 ± 3 years. Atypical clinical presentation was seen in 38.3% with intractable epilepsy (8.5%), focal deficit (8.5%) and extrapyramidal symptoms (8.5%) being commonest followed by coma (6.4%), visual loss (4.3%) and psychosis (2.1%). Neuroimaging was suggestive of cortical hyperintensities in 46.8% and was normal in 46.8%. Electroencephalography showed burst suppression in 55.3% and atypical findings in 19.1%. Younger age (1-1.5 years) of measles and unimmunized status were associated with early onset of SSPE with a p-value of 0.001 and 0.05 respectively. Non-immunized status was associated with atypical presentation of SSPE (p-value <0.05). Conclusion: The younger age of measles infection and failure to receive complete immunization led to early onset of Subacute sclerosing panencephalitis with an atypical presentation.Areeba WasimJaveria Raza AlviNatasha GhaniAthar KhalilyZia Ur RehmanTipu SultanArmy Medical College Rawalpindiarticleanti-measles antibodieselectroencephalographyMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 5, Pp 1839-1843 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-measles antibodies electroencephalography Medicine R Medicine (General) R5-920
spellingShingle	anti-measles antibodies electroencephalography Medicine R Medicine (General) R5-920 Areeba Wasim Javeria Raza Alvi Natasha Ghani Athar Khalily Zia Ur Rehman Tipu Sultan VARIATIONS IN CLINICAL PRESENTATION, NEUROIMAGING AND EEG PATTERNS OF SUBACUTE SCLEROSING PANENCEPHALITIS
description	Objective: To determine the variations in clinical presentation, neuroimaging and electroencephalography patterns of subacute sclerosing panencephalitis. Study Design: Cross-sectional study. Place and Duration of Study: Children’s Hospital & Institute of Child Health, Lahore, Pakistan, from Jul to Dec 2020. Methodology: We recruited children presented with clinical features suggestive of subacute sclerosing panencephalitis, along with positive anti-measles antibodies on cerebrospinal fluid. Association between variables was determined to formulate an early diagnosis of subacute sclerosing panencephalitis. Results: Out of 47 children, 29 were males with a mean age of 6.54 ± 2.9 years. Only 23% were fully immunized against measles, 36.2% were unvaccinated and 40.4% received partial immunization. The mean age of measles infection was 1.49 ± 1.2 years; the mean interval between measles and onset of SSPE was 4.13 ± 3 years. Atypical clinical presentation was seen in 38.3% with intractable epilepsy (8.5%), focal deficit (8.5%) and extrapyramidal symptoms (8.5%) being commonest followed by coma (6.4%), visual loss (4.3%) and psychosis (2.1%). Neuroimaging was suggestive of cortical hyperintensities in 46.8% and was normal in 46.8%. Electroencephalography showed burst suppression in 55.3% and atypical findings in 19.1%. Younger age (1-1.5 years) of measles and unimmunized status were associated with early onset of SSPE with a p-value of 0.001 and 0.05 respectively. Non-immunized status was associated with atypical presentation of SSPE (p-value <0.05). Conclusion: The younger age of measles infection and failure to receive complete immunization led to early onset of Subacute sclerosing panencephalitis with an atypical presentation.
format	article
author	Areeba Wasim Javeria Raza Alvi Natasha Ghani Athar Khalily Zia Ur Rehman Tipu Sultan
author_facet	Areeba Wasim Javeria Raza Alvi Natasha Ghani Athar Khalily Zia Ur Rehman Tipu Sultan
author_sort	Areeba Wasim
title	VARIATIONS IN CLINICAL PRESENTATION, NEUROIMAGING AND EEG PATTERNS OF SUBACUTE SCLEROSING PANENCEPHALITIS
title_short	VARIATIONS IN CLINICAL PRESENTATION, NEUROIMAGING AND EEG PATTERNS OF SUBACUTE SCLEROSING PANENCEPHALITIS
title_full	VARIATIONS IN CLINICAL PRESENTATION, NEUROIMAGING AND EEG PATTERNS OF SUBACUTE SCLEROSING PANENCEPHALITIS
title_fullStr	VARIATIONS IN CLINICAL PRESENTATION, NEUROIMAGING AND EEG PATTERNS OF SUBACUTE SCLEROSING PANENCEPHALITIS
title_full_unstemmed	VARIATIONS IN CLINICAL PRESENTATION, NEUROIMAGING AND EEG PATTERNS OF SUBACUTE SCLEROSING PANENCEPHALITIS
title_sort	variations in clinical presentation, neuroimaging and eeg patterns of subacute sclerosing panencephalitis
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/fc413ed182944158b08e2bb06da7f53f
work_keys_str_mv	AT areebawasim variationsinclinicalpresentationneuroimagingandeegpatternsofsubacutesclerosingpanencephalitis AT javeriarazaalvi variationsinclinicalpresentationneuroimagingandeegpatternsofsubacutesclerosingpanencephalitis AT natashaghani variationsinclinicalpresentationneuroimagingandeegpatternsofsubacutesclerosingpanencephalitis AT atharkhalily variationsinclinicalpresentationneuroimagingandeegpatternsofsubacutesclerosingpanencephalitis AT ziaurrehman variationsinclinicalpresentationneuroimagingandeegpatternsofsubacutesclerosingpanencephalitis AT tipusultan variationsinclinicalpresentationneuroimagingandeegpatternsofsubacutesclerosingpanencephalitis
_version_	1718416071506001920

VARIATIONS IN CLINICAL PRESENTATION, NEUROIMAGING AND EEG PATTERNS OF SUBACUTE SCLEROSING PANENCEPHALITIS

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