Altered Risk-Taking Behavior in Early-Stage Bipolar Disorder With a History of Psychosis

Altered risk-taking propensity is an important determinant of functional impairment in bipolar disorder. However, prior studies primarily assessed patients with chronic illness, and risk-taking has not been evaluated in the early illness course. This study investigated risk-taking behavior in 39 eut...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sandra Chi Yiu Wong, Mary Chung Mun Ng, Joe Kwun Nam Chan, Martha Sin Ki Luk, Simon Sai Yu Lui, Eric Yu Hai Chen, Wing Chung Chang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	risk taking risky decision-making bipolar disorder psychosis BART 2 Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/fc46241a4daf4600adc45e616057501c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fc46241a4daf4600adc45e616057501c
record_format	dspace
spelling	oai:doaj.org-article:fc46241a4daf4600adc45e616057501c2021-11-18T09:26:46ZAltered Risk-Taking Behavior in Early-Stage Bipolar Disorder With a History of Psychosis1664-064010.3389/fpsyt.2021.763545https://doaj.org/article/fc46241a4daf4600adc45e616057501c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.763545/fullhttps://doaj.org/toc/1664-0640Altered risk-taking propensity is an important determinant of functional impairment in bipolar disorder. However, prior studies primarily assessed patients with chronic illness, and risk-taking has not been evaluated in the early illness course. This study investigated risk-taking behavior in 39 euthymic early-stage bipolar disorder patients aged 16–40 years who were treated within 3 years from their first-episode mania with psychotic features and 36 demographically-matched healthy controls using the Balloon Analog Risk Task (BART), a well-validated risk-taking performance-based paradigm requiring participants to make responses for cumulative gain at increasing risk of loss. Relationships of risk-taking indices with symptoms, self-reported impulsivity, cognitive functions, and treatment characteristics were also assessed. Our results showed that patients exhibited significantly lower adjusted scores (i.e., average balloon pumps in unexploded trials) (p = 0.001), lower explosion rate (p = 0.007) and lower cumulative scores (p = 0.003) than controls on BART, indicating their suboptimal risk-taking performance with increased propensity for risk aversion. Risk-taking indices were not correlated with any symptom dimensions, self-reported impulsivity, cognitive functions or antipsychotic dose. No significant difference was observed between patients with and without antipsychotic medications on self-reported impulsivity or any of the BART performance indices. This is the first study to examine risk-taking behavior in early-stage bipolar disorder with history of psychosis and indicates that patients displayed altered risk-taking with increased risk aversion compared with controls. Further research is needed to clarify longitudinal trajectory of risk-taking propensity and its relationships with psychosis and functional outcome in the early stage of bipolar disorder.Sandra Chi Yiu WongMary Chung Mun NgJoe Kwun Nam ChanMartha Sin Ki LukSimon Sai Yu LuiEric Yu Hai ChenEric Yu Hai ChenWing Chung ChangWing Chung ChangFrontiers Media S.A.articlerisk takingrisky decision-makingbipolar disorderpsychosisBART 2PsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	risk taking risky decision-making bipolar disorder psychosis BART 2 Psychiatry RC435-571
spellingShingle	risk taking risky decision-making bipolar disorder psychosis BART 2 Psychiatry RC435-571 Sandra Chi Yiu Wong Mary Chung Mun Ng Joe Kwun Nam Chan Martha Sin Ki Luk Simon Sai Yu Lui Eric Yu Hai Chen Eric Yu Hai Chen Wing Chung Chang Wing Chung Chang Altered Risk-Taking Behavior in Early-Stage Bipolar Disorder With a History of Psychosis
description	Altered risk-taking propensity is an important determinant of functional impairment in bipolar disorder. However, prior studies primarily assessed patients with chronic illness, and risk-taking has not been evaluated in the early illness course. This study investigated risk-taking behavior in 39 euthymic early-stage bipolar disorder patients aged 16–40 years who were treated within 3 years from their first-episode mania with psychotic features and 36 demographically-matched healthy controls using the Balloon Analog Risk Task (BART), a well-validated risk-taking performance-based paradigm requiring participants to make responses for cumulative gain at increasing risk of loss. Relationships of risk-taking indices with symptoms, self-reported impulsivity, cognitive functions, and treatment characteristics were also assessed. Our results showed that patients exhibited significantly lower adjusted scores (i.e., average balloon pumps in unexploded trials) (p = 0.001), lower explosion rate (p = 0.007) and lower cumulative scores (p = 0.003) than controls on BART, indicating their suboptimal risk-taking performance with increased propensity for risk aversion. Risk-taking indices were not correlated with any symptom dimensions, self-reported impulsivity, cognitive functions or antipsychotic dose. No significant difference was observed between patients with and without antipsychotic medications on self-reported impulsivity or any of the BART performance indices. This is the first study to examine risk-taking behavior in early-stage bipolar disorder with history of psychosis and indicates that patients displayed altered risk-taking with increased risk aversion compared with controls. Further research is needed to clarify longitudinal trajectory of risk-taking propensity and its relationships with psychosis and functional outcome in the early stage of bipolar disorder.
format	article
author	Sandra Chi Yiu Wong Mary Chung Mun Ng Joe Kwun Nam Chan Martha Sin Ki Luk Simon Sai Yu Lui Eric Yu Hai Chen Eric Yu Hai Chen Wing Chung Chang Wing Chung Chang
author_facet	Sandra Chi Yiu Wong Mary Chung Mun Ng Joe Kwun Nam Chan Martha Sin Ki Luk Simon Sai Yu Lui Eric Yu Hai Chen Eric Yu Hai Chen Wing Chung Chang Wing Chung Chang
author_sort	Sandra Chi Yiu Wong
title	Altered Risk-Taking Behavior in Early-Stage Bipolar Disorder With a History of Psychosis
title_short	Altered Risk-Taking Behavior in Early-Stage Bipolar Disorder With a History of Psychosis
title_full	Altered Risk-Taking Behavior in Early-Stage Bipolar Disorder With a History of Psychosis
title_fullStr	Altered Risk-Taking Behavior in Early-Stage Bipolar Disorder With a History of Psychosis
title_full_unstemmed	Altered Risk-Taking Behavior in Early-Stage Bipolar Disorder With a History of Psychosis
title_sort	altered risk-taking behavior in early-stage bipolar disorder with a history of psychosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/fc46241a4daf4600adc45e616057501c
work_keys_str_mv	AT sandrachiyiuwong alteredrisktakingbehaviorinearlystagebipolardisorderwithahistoryofpsychosis AT marychungmunng alteredrisktakingbehaviorinearlystagebipolardisorderwithahistoryofpsychosis AT joekwunnamchan alteredrisktakingbehaviorinearlystagebipolardisorderwithahistoryofpsychosis AT marthasinkiluk alteredrisktakingbehaviorinearlystagebipolardisorderwithahistoryofpsychosis AT simonsaiyului alteredrisktakingbehaviorinearlystagebipolardisorderwithahistoryofpsychosis AT ericyuhaichen alteredrisktakingbehaviorinearlystagebipolardisorderwithahistoryofpsychosis AT ericyuhaichen alteredrisktakingbehaviorinearlystagebipolardisorderwithahistoryofpsychosis AT wingchungchang alteredrisktakingbehaviorinearlystagebipolardisorderwithahistoryofpsychosis AT wingchungchang alteredrisktakingbehaviorinearlystagebipolardisorderwithahistoryofpsychosis
_version_	1718420941529153536

Altered Risk-Taking Behavior in Early-Stage Bipolar Disorder With a History of Psychosis

Ejemplares similares