Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III)

Thomas O Obisesan, Nisser Umar, Nivedh Paluvoi, Richard F GillumDivision of Geriatrics, Howard University Hospital, Washington, DC, USAObjective: To test the hypothesis that aerobic-related leisure-time physical activity (PA) is associated with better cognitive function and that the effect varies am...

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Autores principales:	Obisesan TO, Umar N, Paluvoi N, Gillum RF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Physical activity Cognition and Apolipoprotein E Gene Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/fc46a9bb30b643ceb9835940ea3da390
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spelling	oai:doaj.org-article:fc46a9bb30b643ceb9835940ea3da3902021-12-02T01:42:15ZAssociation of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III)1178-1998https://doaj.org/article/fc46a9bb30b643ceb9835940ea3da3902012-01-01T00:00:00Zhttps://www.dovepress.com/association-of-leisure-time-physical-activity-with-cognition-by-apolip-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Thomas O Obisesan, Nisser Umar, Nivedh Paluvoi, Richard F GillumDivision of Geriatrics, Howard University Hospital, Washington, DC, USAObjective: To test the hypothesis that aerobic-related leisure-time physical activity (PA) is associated with better cognitive function and that the effect varies among apolipoprotein E (APOE) genotype groups.Design: Cross-sectional study of persons examined in the Third National Health and Nutrition Examination Survey (NHANES-III; 1988–1994).Setting: US noninstitutionalized population.Participants and methods: From a sample of 7159, aged ≥60 years, we analyzed data for 1799 older American men and women who had information on PA, a short mental status examination (SMSE), and were genotyped at the apolipoprotein E gene locus.Results: In the initial bivariate analysis, non-ε4 carriers and ε4-heterozygotes performed better than ε4-homozygotes in the 60–69 age group. After controlling for multiple confounders including mobility limitation, PA correlated with a higher SMSE score in non-ε4 carriers (P = 0.014), but not in ε4 carriers (P = 0.887). At ≥70 years, PA also correlated with higher adjusted SMSE scores in non- ε4 carriers (P = 0.02); but this association became nonsignificant after controlling for mobility limitation (P = 0.12).Conclusion: In a nationally representative sample, PA was associated with enhanced cognition, an effect that was differentially influenced by apolipoprotein E genotype. Experimental studies are needed to determine whether or not PA can attenuate cognitive decline.Keywords: cognition, physical activity, apolipoprotein E gene, agingObisesan TOUmar NPaluvoi NGillum RFDove Medical PressarticlePhysical activityCognition and Apolipoprotein E GeneGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 7, Pp 35-43 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Physical activity Cognition and Apolipoprotein E Gene Geriatrics RC952-954.6
spellingShingle	Physical activity Cognition and Apolipoprotein E Gene Geriatrics RC952-954.6 Obisesan TO Umar N Paluvoi N Gillum RF Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III)
description	Thomas O Obisesan, Nisser Umar, Nivedh Paluvoi, Richard F GillumDivision of Geriatrics, Howard University Hospital, Washington, DC, USAObjective: To test the hypothesis that aerobic-related leisure-time physical activity (PA) is associated with better cognitive function and that the effect varies among apolipoprotein E (APOE) genotype groups.Design: Cross-sectional study of persons examined in the Third National Health and Nutrition Examination Survey (NHANES-III; 1988–1994).Setting: US noninstitutionalized population.Participants and methods: From a sample of 7159, aged ≥60 years, we analyzed data for 1799 older American men and women who had information on PA, a short mental status examination (SMSE), and were genotyped at the apolipoprotein E gene locus.Results: In the initial bivariate analysis, non-ε4 carriers and ε4-heterozygotes performed better than ε4-homozygotes in the 60–69 age group. After controlling for multiple confounders including mobility limitation, PA correlated with a higher SMSE score in non-ε4 carriers (P = 0.014), but not in ε4 carriers (P = 0.887). At ≥70 years, PA also correlated with higher adjusted SMSE scores in non- ε4 carriers (P = 0.02); but this association became nonsignificant after controlling for mobility limitation (P = 0.12).Conclusion: In a nationally representative sample, PA was associated with enhanced cognition, an effect that was differentially influenced by apolipoprotein E genotype. Experimental studies are needed to determine whether or not PA can attenuate cognitive decline.Keywords: cognition, physical activity, apolipoprotein E gene, aging
format	article
author	Obisesan TO Umar N Paluvoi N Gillum RF
author_facet	Obisesan TO Umar N Paluvoi N Gillum RF
author_sort	Obisesan TO
title	Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III)
title_short	Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III)
title_full	Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III)
title_fullStr	Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III)
title_full_unstemmed	Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III)
title_sort	association of leisure-time physical activity with cognition by apolipoprotein-e genotype in persons aged 60 years and over: the national health and nutrition examination survey (nhanes-iii)
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/fc46a9bb30b643ceb9835940ea3da390
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Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III)

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