Corneal transplantation for keratoconus in South Korea

Abstract This nationwide population-based study investigated the incidence rate of and risk factors for the progression to corneal transplantation in patients with keratoconus in South Korea using claims data from the Health Insurance Review and Assessment service. Among the entire South Korean popu...

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Autores principales:	Sungsoon Hwang, Tae-Young Chung, Jisang Han, Kyunga Kim, Dong Hui Lim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fc4d4c6d47724cf1961a4577e41c485e
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spelling	oai:doaj.org-article:fc4d4c6d47724cf1961a4577e41c485e2021-12-02T17:40:45ZCorneal transplantation for keratoconus in South Korea10.1038/s41598-021-92133-y2045-2322https://doaj.org/article/fc4d4c6d47724cf1961a4577e41c485e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92133-yhttps://doaj.org/toc/2045-2322Abstract This nationwide population-based study investigated the incidence rate of and risk factors for the progression to corneal transplantation in patients with keratoconus in South Korea using claims data from the Health Insurance Review and Assessment service. Among the entire South Korean population, 10,612 patients newly diagnosed with keratoconus between January 2010 and June 2015 were identified and included in the study. During the study period, 124 patients (1.17%) underwent corneal transplantation, with an average follow-up period of 2.97 ± 1.59 years. The incidence rate of corneal transplantation in patients with keratoconus was 4.46 cases per 1000 person-years. The rate of corneal transplantation for keratoconus was relatively low in South Korea compared to other countries. Multivariate Cox regression analysis revealed that male sex (HR 2.37; 95% CI 1.61–3.50; P < 0.001), severe atopic dermatitis (HR 2.32; 95% CI 1.02–5.28; P = 0.044), obstructive sleep apnea (HR 9.78; 95% CI 1.36–70.10; P = 0.023), and intellectual disability (HR 4.48; 95% CI 1.33–15.11; P = 0.016) significantly increased the risk of progression to corneal transplantation. In patients with keratoconus, male sex, severe atopic dermatitis, obstructive sleep apnea, and intellectual disability were associated with an increased risk of corneal transplantation.Sungsoon HwangTae-Young ChungJisang HanKyunga KimDong Hui LimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sungsoon Hwang Tae-Young Chung Jisang Han Kyunga Kim Dong Hui Lim Corneal transplantation for keratoconus in South Korea
description	Abstract This nationwide population-based study investigated the incidence rate of and risk factors for the progression to corneal transplantation in patients with keratoconus in South Korea using claims data from the Health Insurance Review and Assessment service. Among the entire South Korean population, 10,612 patients newly diagnosed with keratoconus between January 2010 and June 2015 were identified and included in the study. During the study period, 124 patients (1.17%) underwent corneal transplantation, with an average follow-up period of 2.97 ± 1.59 years. The incidence rate of corneal transplantation in patients with keratoconus was 4.46 cases per 1000 person-years. The rate of corneal transplantation for keratoconus was relatively low in South Korea compared to other countries. Multivariate Cox regression analysis revealed that male sex (HR 2.37; 95% CI 1.61–3.50; P < 0.001), severe atopic dermatitis (HR 2.32; 95% CI 1.02–5.28; P = 0.044), obstructive sleep apnea (HR 9.78; 95% CI 1.36–70.10; P = 0.023), and intellectual disability (HR 4.48; 95% CI 1.33–15.11; P = 0.016) significantly increased the risk of progression to corneal transplantation. In patients with keratoconus, male sex, severe atopic dermatitis, obstructive sleep apnea, and intellectual disability were associated with an increased risk of corneal transplantation.
format	article
author	Sungsoon Hwang Tae-Young Chung Jisang Han Kyunga Kim Dong Hui Lim
author_facet	Sungsoon Hwang Tae-Young Chung Jisang Han Kyunga Kim Dong Hui Lim
author_sort	Sungsoon Hwang
title	Corneal transplantation for keratoconus in South Korea
title_short	Corneal transplantation for keratoconus in South Korea
title_full	Corneal transplantation for keratoconus in South Korea
title_fullStr	Corneal transplantation for keratoconus in South Korea
title_full_unstemmed	Corneal transplantation for keratoconus in South Korea
title_sort	corneal transplantation for keratoconus in south korea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fc4d4c6d47724cf1961a4577e41c485e
work_keys_str_mv	AT sungsoonhwang cornealtransplantationforkeratoconusinsouthkorea AT taeyoungchung cornealtransplantationforkeratoconusinsouthkorea AT jisanghan cornealtransplantationforkeratoconusinsouthkorea AT kyungakim cornealtransplantationforkeratoconusinsouthkorea AT donghuilim cornealtransplantationforkeratoconusinsouthkorea
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Corneal transplantation for keratoconus in South Korea

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