“Hot cross bun” is a potential imaging marker for the severity of cerebellar ataxia in MSA-C

Abstract To evaluate the correlation between “hot cross bun” sign (HCBs) and disease severity in multiple system atrophy (MSA). We recruited patients with probable and possible MSA with parkinsonism (MSA-P) or the cerebellar ataxia (MSA-C) subtypes. Clinical and imaging characteristics were collecte...

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Autores principales:	Shuzhen Zhu, Bin Deng, Zifeng Huang, Zihan Chang, Hualin Li, Hui Liu, Yanjun Huang, Ying Pan, Yanping Wang, Yin-Xia Chao, Ling-Ling Chan, Yih-Ru Wu, Eng-King Tan, Qing Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/fc4d7deb2327418aa2b88ba42976183e
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spelling	oai:doaj.org-article:fc4d7deb2327418aa2b88ba42976183e2021-12-02T14:21:43Z“Hot cross bun” is a potential imaging marker for the severity of cerebellar ataxia in MSA-C10.1038/s41531-021-00159-w2373-8057https://doaj.org/article/fc4d7deb2327418aa2b88ba42976183e2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00159-whttps://doaj.org/toc/2373-8057Abstract To evaluate the correlation between “hot cross bun” sign (HCBs) and disease severity in multiple system atrophy (MSA). We recruited patients with probable and possible MSA with parkinsonism (MSA-P) or the cerebellar ataxia (MSA-C) subtypes. Clinical and imaging characteristics were collected and comparison was performed between MSA-C and MSA-P cases. Spearman test was used to evaluate the correlation between HCBs and other variables. Curve estimate and general linear regression was performed to evaluate the relationship between HCBs and the Scale for Assessment and Rating of Ataxia (SARA). Unified Multiple System Atrophy Rating Scale (UMSARS) IV was used to assess the severity of disease. Multinomial ordered logistic regression was used to confirm the increased likelihood of disability for the disease. Eighty-one MSA with HCBs comprising of 50 MSA-C and 31 MSA-P were recruited. We demonstrated that the severity of HCBs showed a positive linear correlation with SARA scores in MSA-C. Multinomial ordered logistic regression test revealed that the increase in the HCBs grade may be associated with an increased likelihood of disability for the disease severity in MSA, especially in those with cerebellar ataxia subtype. We demonstrated that HCBs is a potential imaging marker for the severity of cerebellar ataxia. The increase in the HCBs grade may be associated with an increased likelihood of disability in MSA-C, but not MSA-P cases, suggesting that it may be a useful imaging indicator for disease progression in Chinese patients with MSA-C.Shuzhen ZhuBin DengZifeng HuangZihan ChangHualin LiHui LiuYanjun HuangYing PanYanping WangYin-Xia ChaoLing-Ling ChanYih-Ru WuEng-King TanQing WangNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Shuzhen Zhu Bin Deng Zifeng Huang Zihan Chang Hualin Li Hui Liu Yanjun Huang Ying Pan Yanping Wang Yin-Xia Chao Ling-Ling Chan Yih-Ru Wu Eng-King Tan Qing Wang “Hot cross bun” is a potential imaging marker for the severity of cerebellar ataxia in MSA-C
description	Abstract To evaluate the correlation between “hot cross bun” sign (HCBs) and disease severity in multiple system atrophy (MSA). We recruited patients with probable and possible MSA with parkinsonism (MSA-P) or the cerebellar ataxia (MSA-C) subtypes. Clinical and imaging characteristics were collected and comparison was performed between MSA-C and MSA-P cases. Spearman test was used to evaluate the correlation between HCBs and other variables. Curve estimate and general linear regression was performed to evaluate the relationship between HCBs and the Scale for Assessment and Rating of Ataxia (SARA). Unified Multiple System Atrophy Rating Scale (UMSARS) IV was used to assess the severity of disease. Multinomial ordered logistic regression was used to confirm the increased likelihood of disability for the disease. Eighty-one MSA with HCBs comprising of 50 MSA-C and 31 MSA-P were recruited. We demonstrated that the severity of HCBs showed a positive linear correlation with SARA scores in MSA-C. Multinomial ordered logistic regression test revealed that the increase in the HCBs grade may be associated with an increased likelihood of disability for the disease severity in MSA, especially in those with cerebellar ataxia subtype. We demonstrated that HCBs is a potential imaging marker for the severity of cerebellar ataxia. The increase in the HCBs grade may be associated with an increased likelihood of disability in MSA-C, but not MSA-P cases, suggesting that it may be a useful imaging indicator for disease progression in Chinese patients with MSA-C.
format	article
author	Shuzhen Zhu Bin Deng Zifeng Huang Zihan Chang Hualin Li Hui Liu Yanjun Huang Ying Pan Yanping Wang Yin-Xia Chao Ling-Ling Chan Yih-Ru Wu Eng-King Tan Qing Wang
author_facet	Shuzhen Zhu Bin Deng Zifeng Huang Zihan Chang Hualin Li Hui Liu Yanjun Huang Ying Pan Yanping Wang Yin-Xia Chao Ling-Ling Chan Yih-Ru Wu Eng-King Tan Qing Wang
author_sort	Shuzhen Zhu
title	“Hot cross bun” is a potential imaging marker for the severity of cerebellar ataxia in MSA-C
title_short	“Hot cross bun” is a potential imaging marker for the severity of cerebellar ataxia in MSA-C
title_full	“Hot cross bun” is a potential imaging marker for the severity of cerebellar ataxia in MSA-C
title_fullStr	“Hot cross bun” is a potential imaging marker for the severity of cerebellar ataxia in MSA-C
title_full_unstemmed	“Hot cross bun” is a potential imaging marker for the severity of cerebellar ataxia in MSA-C
title_sort	“hot cross bun” is a potential imaging marker for the severity of cerebellar ataxia in msa-c
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fc4d7deb2327418aa2b88ba42976183e
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“Hot cross bun” is a potential imaging marker for the severity of cerebellar ataxia in MSA-C

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