IgG responses to Anopheles gambiae salivary antigen gSG6 detect variation in exposure to malaria vectors and disease risk.
Assessment of exposure to malaria vectors is important to our understanding of spatial and temporal variations in disease transmission and facilitates the targeting and evaluation of control efforts. Recently, an immunogenic Anopheles gambiae salivary protein (gSG6) was identified and proposed as th...
Guardado en:
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2012
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/fc5047b8aaea4619a61827db43ea834b |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:fc5047b8aaea4619a61827db43ea834b |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:fc5047b8aaea4619a61827db43ea834b2021-11-18T07:13:40ZIgG responses to Anopheles gambiae salivary antigen gSG6 detect variation in exposure to malaria vectors and disease risk.1932-620310.1371/journal.pone.0040170https://doaj.org/article/fc5047b8aaea4619a61827db43ea834b2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22768250/?tool=EBIhttps://doaj.org/toc/1932-6203Assessment of exposure to malaria vectors is important to our understanding of spatial and temporal variations in disease transmission and facilitates the targeting and evaluation of control efforts. Recently, an immunogenic Anopheles gambiae salivary protein (gSG6) was identified and proposed as the basis of an immuno-assay determining exposure to Afrotropical malaria vectors. In the present study, IgG responses to gSG6 and 6 malaria antigens (CSP, AMA-1, MSP-1, MSP-3, GLURP R1, and GLURP R2) were compared to Anopheles exposure and malaria incidence in a cohort of children from Korogwe district, Tanzania, an area of moderate and heterogeneous malaria transmission. Anti-gSG6 responses above the threshold for seropositivity were detected in 15% (96/636) of the children, and were positively associated with geographical variations in Anopheles exposure (OR 1.25, CI 1.01-1.54, p = 0.04). Additionally, IgG responses to gSG6 in individual children showed a strong positive association with household level mosquito exposure. IgG levels for all antigens except AMA-1 were associated with the frequency of malaria episodes following sampling. gSG6 seropositivity was strongly positively associated with subsequent malaria incidence (test for trend p = 0.004), comparable to malaria antigens MSP-1 and GLURP R2. Our results show that the gSG6 assay is sensitive to micro-epidemiological variations in exposure to Anopheles mosquitoes, and provides a correlate of malaria risk that is unrelated to immune protection. While the technique requires further evaluation in a range of malaria endemic settings, our findings suggest that the gSG6 assay may have a role in the evaluation and planning of targeted and preventative anti-malaria interventions.Will StoneTeun BousemaSophie JonesSamwel GesaseRhamadhan HashimRoly GoslingIlona CarneiroDaniel ChandramohanThor TheanderRaffaele RoncaDavid ModianoBruno ArcàChris DrakeleyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e40170 (2012) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Will Stone Teun Bousema Sophie Jones Samwel Gesase Rhamadhan Hashim Roly Gosling Ilona Carneiro Daniel Chandramohan Thor Theander Raffaele Ronca David Modiano Bruno Arcà Chris Drakeley IgG responses to Anopheles gambiae salivary antigen gSG6 detect variation in exposure to malaria vectors and disease risk. |
| description |
Assessment of exposure to malaria vectors is important to our understanding of spatial and temporal variations in disease transmission and facilitates the targeting and evaluation of control efforts. Recently, an immunogenic Anopheles gambiae salivary protein (gSG6) was identified and proposed as the basis of an immuno-assay determining exposure to Afrotropical malaria vectors. In the present study, IgG responses to gSG6 and 6 malaria antigens (CSP, AMA-1, MSP-1, MSP-3, GLURP R1, and GLURP R2) were compared to Anopheles exposure and malaria incidence in a cohort of children from Korogwe district, Tanzania, an area of moderate and heterogeneous malaria transmission. Anti-gSG6 responses above the threshold for seropositivity were detected in 15% (96/636) of the children, and were positively associated with geographical variations in Anopheles exposure (OR 1.25, CI 1.01-1.54, p = 0.04). Additionally, IgG responses to gSG6 in individual children showed a strong positive association with household level mosquito exposure. IgG levels for all antigens except AMA-1 were associated with the frequency of malaria episodes following sampling. gSG6 seropositivity was strongly positively associated with subsequent malaria incidence (test for trend p = 0.004), comparable to malaria antigens MSP-1 and GLURP R2. Our results show that the gSG6 assay is sensitive to micro-epidemiological variations in exposure to Anopheles mosquitoes, and provides a correlate of malaria risk that is unrelated to immune protection. While the technique requires further evaluation in a range of malaria endemic settings, our findings suggest that the gSG6 assay may have a role in the evaluation and planning of targeted and preventative anti-malaria interventions. |
| format |
article |
| author |
Will Stone Teun Bousema Sophie Jones Samwel Gesase Rhamadhan Hashim Roly Gosling Ilona Carneiro Daniel Chandramohan Thor Theander Raffaele Ronca David Modiano Bruno Arcà Chris Drakeley |
| author_facet |
Will Stone Teun Bousema Sophie Jones Samwel Gesase Rhamadhan Hashim Roly Gosling Ilona Carneiro Daniel Chandramohan Thor Theander Raffaele Ronca David Modiano Bruno Arcà Chris Drakeley |
| author_sort |
Will Stone |
| title |
IgG responses to Anopheles gambiae salivary antigen gSG6 detect variation in exposure to malaria vectors and disease risk. |
| title_short |
IgG responses to Anopheles gambiae salivary antigen gSG6 detect variation in exposure to malaria vectors and disease risk. |
| title_full |
IgG responses to Anopheles gambiae salivary antigen gSG6 detect variation in exposure to malaria vectors and disease risk. |
| title_fullStr |
IgG responses to Anopheles gambiae salivary antigen gSG6 detect variation in exposure to malaria vectors and disease risk. |
| title_full_unstemmed |
IgG responses to Anopheles gambiae salivary antigen gSG6 detect variation in exposure to malaria vectors and disease risk. |
| title_sort |
igg responses to anopheles gambiae salivary antigen gsg6 detect variation in exposure to malaria vectors and disease risk. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/fc5047b8aaea4619a61827db43ea834b |
| work_keys_str_mv |
AT willstone iggresponsestoanophelesgambiaesalivaryantigengsg6detectvariationinexposuretomalariavectorsanddiseaserisk AT teunbousema iggresponsestoanophelesgambiaesalivaryantigengsg6detectvariationinexposuretomalariavectorsanddiseaserisk AT sophiejones iggresponsestoanophelesgambiaesalivaryantigengsg6detectvariationinexposuretomalariavectorsanddiseaserisk AT samwelgesase iggresponsestoanophelesgambiaesalivaryantigengsg6detectvariationinexposuretomalariavectorsanddiseaserisk AT rhamadhanhashim iggresponsestoanophelesgambiaesalivaryantigengsg6detectvariationinexposuretomalariavectorsanddiseaserisk AT rolygosling iggresponsestoanophelesgambiaesalivaryantigengsg6detectvariationinexposuretomalariavectorsanddiseaserisk AT ilonacarneiro iggresponsestoanophelesgambiaesalivaryantigengsg6detectvariationinexposuretomalariavectorsanddiseaserisk AT danielchandramohan iggresponsestoanophelesgambiaesalivaryantigengsg6detectvariationinexposuretomalariavectorsanddiseaserisk AT thortheander iggresponsestoanophelesgambiaesalivaryantigengsg6detectvariationinexposuretomalariavectorsanddiseaserisk AT raffaeleronca iggresponsestoanophelesgambiaesalivaryantigengsg6detectvariationinexposuretomalariavectorsanddiseaserisk AT davidmodiano iggresponsestoanophelesgambiaesalivaryantigengsg6detectvariationinexposuretomalariavectorsanddiseaserisk AT brunoarca iggresponsestoanophelesgambiaesalivaryantigengsg6detectvariationinexposuretomalariavectorsanddiseaserisk AT chrisdrakeley iggresponsestoanophelesgambiaesalivaryantigengsg6detectvariationinexposuretomalariavectorsanddiseaserisk |
| _version_ |
1718423767252729856 |