Structural basis for assembly of non-canonical small subunits into type I-C Cascade

Structural basis for assembly of non-canonical small subunits into type I-C Cascade

Type I-C Cascade (the CRISPR-associated complex for antiviral defense) is a minimal system, comprising only three unique Cas proteins. Cryo-EM structure of the Desulfovibrio vulgaris type I-C Cascade reveals the molecular mechanisms that underlie RNA-directed complex assembly.

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Detalles Bibliográficos
Autores principales: Roisin E. O’Brien, Inês C. Santos, Daniel Wrapp, Jack P. K. Bravo, Evan A. Schwartz, Jennifer S. Brodbelt, David W. Taylor
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/fc5250035c114ed7829c434b6fd80c1f
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Descripción
Sumario:Type I-C Cascade (the CRISPR-associated complex for antiviral defense) is a minimal system, comprising only three unique Cas proteins. Cryo-EM structure of the Desulfovibrio vulgaris type I-C Cascade reveals the molecular mechanisms that underlie RNA-directed complex assembly.

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