Structural basis for assembly of non-canonical small subunits into type I-C Cascade

Type I-C Cascade (the CRISPR-associated complex for antiviral defense) is a minimal system, comprising only three unique Cas proteins. Cryo-EM structure of the Desulfovibrio vulgaris type I-C Cascade reveals the molecular mechanisms that underlie RNA-directed complex assembly.

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Autores principales:	Roisin E. O’Brien, Inês C. Santos, Daniel Wrapp, Jack P. K. Bravo, Evan A. Schwartz, Jennifer S. Brodbelt, David W. Taylor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fc5250035c114ed7829c434b6fd80c1f
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spelling	oai:doaj.org-article:fc5250035c114ed7829c434b6fd80c1f2021-12-02T14:16:05ZStructural basis for assembly of non-canonical small subunits into type I-C Cascade10.1038/s41467-020-19785-82041-1723https://doaj.org/article/fc5250035c114ed7829c434b6fd80c1f2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19785-8https://doaj.org/toc/2041-1723Type I-C Cascade (the CRISPR-associated complex for antiviral defense) is a minimal system, comprising only three unique Cas proteins. Cryo-EM structure of the Desulfovibrio vulgaris type I-C Cascade reveals the molecular mechanisms that underlie RNA-directed complex assembly.Roisin E. O’BrienInês C. SantosDaniel WrappJack P. K. BravoEvan A. SchwartzJennifer S. BrodbeltDavid W. TaylorNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roisin E. O’Brien Inês C. Santos Daniel Wrapp Jack P. K. Bravo Evan A. Schwartz Jennifer S. Brodbelt David W. Taylor Structural basis for assembly of non-canonical small subunits into type I-C Cascade
description	Type I-C Cascade (the CRISPR-associated complex for antiviral defense) is a minimal system, comprising only three unique Cas proteins. Cryo-EM structure of the Desulfovibrio vulgaris type I-C Cascade reveals the molecular mechanisms that underlie RNA-directed complex assembly.
format	article
author	Roisin E. O’Brien Inês C. Santos Daniel Wrapp Jack P. K. Bravo Evan A. Schwartz Jennifer S. Brodbelt David W. Taylor
author_facet	Roisin E. O’Brien Inês C. Santos Daniel Wrapp Jack P. K. Bravo Evan A. Schwartz Jennifer S. Brodbelt David W. Taylor
author_sort	Roisin E. O’Brien
title	Structural basis for assembly of non-canonical small subunits into type I-C Cascade
title_short	Structural basis for assembly of non-canonical small subunits into type I-C Cascade
title_full	Structural basis for assembly of non-canonical small subunits into type I-C Cascade
title_fullStr	Structural basis for assembly of non-canonical small subunits into type I-C Cascade
title_full_unstemmed	Structural basis for assembly of non-canonical small subunits into type I-C Cascade
title_sort	structural basis for assembly of non-canonical small subunits into type i-c cascade
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fc5250035c114ed7829c434b6fd80c1f
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Structural basis for assembly of non-canonical small subunits into type I-C Cascade

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