Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas

Alahmady H Alsmman, Amr Mounir Department of Ophthalmology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt Aim: To evaluate the clinical effectiveness of combined oral propranolol with intralesional injection of triamcinolone acetonide in the treatment of infantile periorbital capillary...

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Autores principales:	Alsmman AH, Mounir A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	infantile periocular haemangioma oral propranolol intralesional injection tri-amcinolone acetonide Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/fc537d945b6a4a6cad9f7cb520a4c10a
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spelling	oai:doaj.org-article:fc537d945b6a4a6cad9f7cb520a4c10a2021-12-02T00:32:42ZCombined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas1177-5483https://doaj.org/article/fc537d945b6a4a6cad9f7cb520a4c10a2017-12-01T00:00:00Zhttps://www.dovepress.com/combined-oral-propranolol-with-intralesional-injection-of-triamcinolon-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Alahmady H Alsmman, Amr Mounir Department of Ophthalmology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt Aim: To evaluate the clinical effectiveness of combined oral propranolol with intralesional injection of triamcinolone acetonide in the treatment of infantile periorbital capillary hemangioma.Patients and Methods: This prospective interventional study included children diagnosed with periocular infantile hemangiomas in the proliferative phase with vision-threatening lesions. The children presented to the oculoplastic unit in Sohag University Hospital in the period between January 2016 and February 2017 and were treated with a combined intralesional injection of triamcinolone acetonide with oral propranolol, with a follow-up period of 6 months. Treatment response was evaluated according to the size of the tumor (horizontal diameter); additionally, complications of both treatment methods were recorded.Results: This study included 33 infants: 21 females (64%) and 12 males (36%). The mean age at the time of injection was 4.9±2.6 months. The study included three modes of treatment response: regression of the tumor, 28 patients (85%); stabilization, three patients (9%); and failure, two patients (6%), which necessitated repeated intralesional injection of triamcinolone but with minimal response. Regarding complications, only one patient reported with subconjunctival hemorrhage during intralesional injection of steroids; there were no recorded cases of hypotension, bradycardia, or hypoglycemia during the course of oral propranolol treatment. After the end of the follow-up period, there were no reported cases of recurrent increase in the size of the regressed group of infantile hemangiomas with stable tumor size.Conclusion: Combined oral propranolol with intralesional injection of triamcinolone acetonide is the effective method of treatment for infantile periorbital capillary hemangioma with minimal adverse effects. Keywords: infantile periocular hemangioma, oral propranolol, intralesional injection, triamcinolone acetonideAlsmman AHMounir ADove Medical Pressarticleinfantile periocular haemangiomaoral propranololintralesional injectiontri-amcinolone acetonideOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 2177-2181 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	infantile periocular haemangioma oral propranolol intralesional injection tri-amcinolone acetonide Ophthalmology RE1-994
spellingShingle	infantile periocular haemangioma oral propranolol intralesional injection tri-amcinolone acetonide Ophthalmology RE1-994 Alsmman AH Mounir A Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas
description	Alahmady H Alsmman, Amr Mounir Department of Ophthalmology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt Aim: To evaluate the clinical effectiveness of combined oral propranolol with intralesional injection of triamcinolone acetonide in the treatment of infantile periorbital capillary hemangioma.Patients and Methods: This prospective interventional study included children diagnosed with periocular infantile hemangiomas in the proliferative phase with vision-threatening lesions. The children presented to the oculoplastic unit in Sohag University Hospital in the period between January 2016 and February 2017 and were treated with a combined intralesional injection of triamcinolone acetonide with oral propranolol, with a follow-up period of 6 months. Treatment response was evaluated according to the size of the tumor (horizontal diameter); additionally, complications of both treatment methods were recorded.Results: This study included 33 infants: 21 females (64%) and 12 males (36%). The mean age at the time of injection was 4.9±2.6 months. The study included three modes of treatment response: regression of the tumor, 28 patients (85%); stabilization, three patients (9%); and failure, two patients (6%), which necessitated repeated intralesional injection of triamcinolone but with minimal response. Regarding complications, only one patient reported with subconjunctival hemorrhage during intralesional injection of steroids; there were no recorded cases of hypotension, bradycardia, or hypoglycemia during the course of oral propranolol treatment. After the end of the follow-up period, there were no reported cases of recurrent increase in the size of the regressed group of infantile hemangiomas with stable tumor size.Conclusion: Combined oral propranolol with intralesional injection of triamcinolone acetonide is the effective method of treatment for infantile periorbital capillary hemangioma with minimal adverse effects. Keywords: infantile periocular hemangioma, oral propranolol, intralesional injection, triamcinolone acetonide
format	article
author	Alsmman AH Mounir A
author_facet	Alsmman AH Mounir A
author_sort	Alsmman AH
title	Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas
title_short	Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas
title_full	Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas
title_fullStr	Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas
title_full_unstemmed	Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas
title_sort	combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/fc537d945b6a4a6cad9f7cb520a4c10a
work_keys_str_mv	AT alsmmanah combinedoralpropranololwithintralesionalinjectionoftriamcinoloneacetonideintreatmentofinfantileperiocularhemangiomas AT mounira combinedoralpropranololwithintralesionalinjectionoftriamcinoloneacetonideintreatmentofinfantileperiocularhemangiomas
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Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas

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