Structure Modification of Quinine on C-9 Hydroxyl Group via Esteriﬁcation Reaction

Concept the role played by modified quinine in the asymmetric hydroxyl group inspired studies of modified quinine as chiral organic that lead to drug discovery development. A simple and efficient method for C-9 alkylation and arylation of quinine derivatives was reported. Series quinine derivatives...

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Autores principales:	Teni Ernawati, Minarti Minarti, Puspa Dewi Narrij Lotulung
Formato:	article
Lenguaje:	EN
Publicado:	University of Brawijaya 2020
Materias:	modification synthesis quinine derivatives ester Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/fc54e426ed7346be810d49cb7090b0e5
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spelling	oai:doaj.org-article:fc54e426ed7346be810d49cb7090b0e52021-12-02T14:22:18ZStructure Modification of Quinine on C-9 Hydroxyl Group via Esteriﬁcation Reaction2302-46902302-4690https://doaj.org/article/fc54e426ed7346be810d49cb7090b0e52020-04-01T00:00:00Zhttps://jpacr.ub.ac.id/index.php/jpacr/article/view/505/pdfhttps://doaj.org/toc/2302-4690https://doaj.org/toc/2302-4690Concept the role played by modified quinine in the asymmetric hydroxyl group inspired studies of modified quinine as chiral organic that lead to drug discovery development. A simple and efficient method for C-9 alkylation and arylation of quinine derivatives was reported. Series quinine derivatives were synthesized through the esterification of the hydroxyl group of quinine. The reaction with various alkyl and aryl carbonyl chloride resulted in the series of ester quinine derivatives. The structure of quinine derivatives was characterized by IR, melting point, UV, 1H NMR, 13C NMR, LCMS.Teni Ernawati Minarti MinartiPuspa Dewi Narrij LotulungUniversity of Brawijayaarticlemodificationsynthesisquinine derivativesesterChemistryQD1-999ENJournal of Pure and Applied Chemistry Research, Vol 9, Iss 1, Pp 32-39 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	modification synthesis quinine derivatives ester Chemistry QD1-999
spellingShingle	modification synthesis quinine derivatives ester Chemistry QD1-999 Teni Ernawati Minarti Minarti Puspa Dewi Narrij Lotulung Structure Modification of Quinine on C-9 Hydroxyl Group via Esteriﬁcation Reaction
description	Concept the role played by modified quinine in the asymmetric hydroxyl group inspired studies of modified quinine as chiral organic that lead to drug discovery development. A simple and efficient method for C-9 alkylation and arylation of quinine derivatives was reported. Series quinine derivatives were synthesized through the esterification of the hydroxyl group of quinine. The reaction with various alkyl and aryl carbonyl chloride resulted in the series of ester quinine derivatives. The structure of quinine derivatives was characterized by IR, melting point, UV, 1H NMR, 13C NMR, LCMS.
format	article
author	Teni Ernawati Minarti Minarti Puspa Dewi Narrij Lotulung
author_facet	Teni Ernawati Minarti Minarti Puspa Dewi Narrij Lotulung
author_sort	Teni Ernawati
title	Structure Modification of Quinine on C-9 Hydroxyl Group via Esteriﬁcation Reaction
title_short	Structure Modification of Quinine on C-9 Hydroxyl Group via Esteriﬁcation Reaction
title_full	Structure Modification of Quinine on C-9 Hydroxyl Group via Esteriﬁcation Reaction
title_fullStr	Structure Modification of Quinine on C-9 Hydroxyl Group via Esteriﬁcation Reaction
title_full_unstemmed	Structure Modification of Quinine on C-9 Hydroxyl Group via Esteriﬁcation Reaction
title_sort	structure modification of quinine on c-9 hydroxyl group via esteriﬁcation reaction
publisher	University of Brawijaya
publishDate	2020
url	https://doaj.org/article/fc54e426ed7346be810d49cb7090b0e5
work_keys_str_mv	AT teniernawati structuremodificationofquinineonc9hydroxylgroupviaesterificationreaction AT minartiminarti structuremodificationofquinineonc9hydroxylgroupviaesterificationreaction AT puspadewinarrijlotulung structuremodificationofquinineonc9hydroxylgroupviaesterificationreaction
_version_	1718391525146099712

Structure Modification of Quinine on C-9 Hydroxyl Group via Esteriﬁcation Reaction

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