Prognostic Value of Vascular-Expressed PSMA and CD248 in Urothelial Carcinoma of the Bladder

BackgroundUrothelial carcinoma of the bladder (UCB) is a common cancer of the urinary system. Despite substantial improvements in available treatment options, the survival outcome of patients with advanced UCB is unsatisfactory. Therefore, it is necessary to identify new prognostic biomarkers for mo...

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Autores principales:	Yu Li, Keying Zhang, Fa Yang, Dian Jiao, Mingyang Li, Xiaolong Zhao, Chao Xu, Shaojie Liu, Hongji Li, Shengjia Shi, Bo Yang, Lijun Yang, Donghui Han, Weihong Wen, Weijun Qin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	PSMA CD248 urothelial carcinoma of the bladder prognosis angiogenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/fc57cfb44040442b8f50e32af516e52f
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spelling	oai:doaj.org-article:fc57cfb44040442b8f50e32af516e52f2021-11-17T07:04:41ZPrognostic Value of Vascular-Expressed PSMA and CD248 in Urothelial Carcinoma of the Bladder2234-943X10.3389/fonc.2021.771036https://doaj.org/article/fc57cfb44040442b8f50e32af516e52f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.771036/fullhttps://doaj.org/toc/2234-943XBackgroundUrothelial carcinoma of the bladder (UCB) is a common cancer of the urinary system. Despite substantial improvements in available treatment options, the survival outcome of patients with advanced UCB is unsatisfactory. Therefore, it is necessary to identify new prognostic biomarkers for monitoring and therapy guidance of UCB. In recent years, prostate-specific membrane antigen (PSMA) and CD248 have been identified promising candidate bio7markers.MethodsIn this study, we first examined PSMA and CD248 expression in tissues from 124 patients with UCB using immunohistochemical and immunofluorescent staining. We then analyzed the association between the expression of the two biomarkers and other clinicopathological features and prognosis. Finally, we performed bioinformatic analysis of CD248 and FOLH 1 (PSMA) using the TCGA-BLCA dataset to explore the underlying mechanism of PSMA and CD248 in the progression of UCB.ResultsAmong the 124 cases, PSMA and CD248 were confirmed to be expressed in tumor-associated vessels. Vascular PSMA and CD248 expression levels were associated significantly with several deteriorated clinicopathological features. Furthermore, using univariate and multivariate Cox analyses, high vascular PSMA and CD248 expression levels were observed to be associated significantly with poor prognosis in patients with UCB. As risk factors, both PSMA and CD248 expression showed good performance to predict prognosis. Furthermore, combining these vascular molecules with other clinical risk factors generated a risk score that could promote predictive performance. Bioinformatic analysis showed that both PSMA and CD248 might contribute to angiogenesis and promote further progression of UCB.ConclusionBoth PSMA and CD248 are specifically expressed in the tumor-associated vasculature of UCB. These two molecules might be used as novel prognostic biomarkers and vascular therapeutic targets for UCB.Yu LiKeying ZhangFa YangDian JiaoMingyang LiXiaolong ZhaoChao XuShaojie LiuHongji LiShengjia ShiBo YangLijun YangDonghui HanWeihong WenWeijun QinFrontiers Media S.A.articlePSMACD248urothelial carcinoma of the bladderprognosisangiogenesisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PSMA CD248 urothelial carcinoma of the bladder prognosis angiogenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	PSMA CD248 urothelial carcinoma of the bladder prognosis angiogenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yu Li Keying Zhang Fa Yang Dian Jiao Mingyang Li Xiaolong Zhao Chao Xu Shaojie Liu Hongji Li Shengjia Shi Bo Yang Lijun Yang Donghui Han Weihong Wen Weijun Qin Prognostic Value of Vascular-Expressed PSMA and CD248 in Urothelial Carcinoma of the Bladder
description	BackgroundUrothelial carcinoma of the bladder (UCB) is a common cancer of the urinary system. Despite substantial improvements in available treatment options, the survival outcome of patients with advanced UCB is unsatisfactory. Therefore, it is necessary to identify new prognostic biomarkers for monitoring and therapy guidance of UCB. In recent years, prostate-specific membrane antigen (PSMA) and CD248 have been identified promising candidate bio7markers.MethodsIn this study, we first examined PSMA and CD248 expression in tissues from 124 patients with UCB using immunohistochemical and immunofluorescent staining. We then analyzed the association between the expression of the two biomarkers and other clinicopathological features and prognosis. Finally, we performed bioinformatic analysis of CD248 and FOLH 1 (PSMA) using the TCGA-BLCA dataset to explore the underlying mechanism of PSMA and CD248 in the progression of UCB.ResultsAmong the 124 cases, PSMA and CD248 were confirmed to be expressed in tumor-associated vessels. Vascular PSMA and CD248 expression levels were associated significantly with several deteriorated clinicopathological features. Furthermore, using univariate and multivariate Cox analyses, high vascular PSMA and CD248 expression levels were observed to be associated significantly with poor prognosis in patients with UCB. As risk factors, both PSMA and CD248 expression showed good performance to predict prognosis. Furthermore, combining these vascular molecules with other clinical risk factors generated a risk score that could promote predictive performance. Bioinformatic analysis showed that both PSMA and CD248 might contribute to angiogenesis and promote further progression of UCB.ConclusionBoth PSMA and CD248 are specifically expressed in the tumor-associated vasculature of UCB. These two molecules might be used as novel prognostic biomarkers and vascular therapeutic targets for UCB.
format	article
author	Yu Li Keying Zhang Fa Yang Dian Jiao Mingyang Li Xiaolong Zhao Chao Xu Shaojie Liu Hongji Li Shengjia Shi Bo Yang Lijun Yang Donghui Han Weihong Wen Weijun Qin
author_facet	Yu Li Keying Zhang Fa Yang Dian Jiao Mingyang Li Xiaolong Zhao Chao Xu Shaojie Liu Hongji Li Shengjia Shi Bo Yang Lijun Yang Donghui Han Weihong Wen Weijun Qin
author_sort	Yu Li
title	Prognostic Value of Vascular-Expressed PSMA and CD248 in Urothelial Carcinoma of the Bladder
title_short	Prognostic Value of Vascular-Expressed PSMA and CD248 in Urothelial Carcinoma of the Bladder
title_full	Prognostic Value of Vascular-Expressed PSMA and CD248 in Urothelial Carcinoma of the Bladder
title_fullStr	Prognostic Value of Vascular-Expressed PSMA and CD248 in Urothelial Carcinoma of the Bladder
title_full_unstemmed	Prognostic Value of Vascular-Expressed PSMA and CD248 in Urothelial Carcinoma of the Bladder
title_sort	prognostic value of vascular-expressed psma and cd248 in urothelial carcinoma of the bladder
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/fc57cfb44040442b8f50e32af516e52f
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Prognostic Value of Vascular-Expressed PSMA and CD248 in Urothelial Carcinoma of the Bladder

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