Predictors of hypoxemia in type-B acute aortic syndrome: a retrospective study

Abstract Acute aortic syndrome (AAS) can be life-threatening owing to a variety of complications, and it is managed in the intensive care unit (ICU). Although Stanford type-B AAS may involve hypoxemia, its predictors are not yet clearly understood. We studied clinical factors and imaging parameters...

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Autores principales:	Yudai Tamura, Yuichi Tamura, Motoko Kametani, Yoshiaki Minami, Tomoko Nakayama, Daisuke Takagi, Takashi Unoki, Megumi Yamamuro, Akio Kawamura, Tomohiro Sakamoto, Tadashi Sawamura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fc5949b03acb4da4bd4fef9b99e08af1
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spelling	oai:doaj.org-article:fc5949b03acb4da4bd4fef9b99e08af12021-12-05T12:13:31ZPredictors of hypoxemia in type-B acute aortic syndrome: a retrospective study10.1038/s41598-021-02886-92045-2322https://doaj.org/article/fc5949b03acb4da4bd4fef9b99e08af12021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02886-9https://doaj.org/toc/2045-2322Abstract Acute aortic syndrome (AAS) can be life-threatening owing to a variety of complications, and it is managed in the intensive care unit (ICU). Although Stanford type-B AAS may involve hypoxemia, its predictors are not yet clearly understood. We studied clinical factors and imaging parameters for predicting hypoxemia after the onset of type-B AAS. We retrospectively analyzed patients diagnosed with type-B AAS in our hospital between January 2012 and April 2020. We defined hypoxemia as PaO2/FiO2 ≤ 200 within 7 days after AAS onset and used logistic regression analysis to evaluate prognostic factors for hypoxemia. We analyzed 224 consecutive patients (140 males, mean age 70 ± 14 years) from a total cohort of 267 patients. Among these, 53 (23.7%) had hypoxemia. The hypoxemia group had longer ICU and hospital stays compared with the non-hypoxemia group (median 20 vs. 16 days, respectively; p = 0.039 and median 7 vs. 5 days, respectively; p < 0.001). Male sex (odds ratio [OR] 2.87; 95% confidence interval [CI] 1.24–6.63; p = 0.014), obesity (OR 2.36; 95% CI 1.13–4.97; p = 0.023), patent false lumen (OR 2.33; 95% CI 1.09–4.99; p = 0.029), and high D-dimer level (OR 1.01; 95% CI 1.00–1.02; p = 0.047) were independently associated with hypoxemia by multivariate logistic analysis. This study showed a significant difference in duration of ICU and hospital stays between patients with and without hypoxemia. Furthermore, male sex, obesity, patent false lumen, and high D-dimer level may be significantly associated with hypoxemia in patients with type-B AAS.Yudai TamuraYuichi TamuraMotoko KametaniYoshiaki MinamiTomoko NakayamaDaisuke TakagiTakashi UnokiMegumi YamamuroAkio KawamuraTomohiro SakamotoTadashi SawamuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yudai Tamura Yuichi Tamura Motoko Kametani Yoshiaki Minami Tomoko Nakayama Daisuke Takagi Takashi Unoki Megumi Yamamuro Akio Kawamura Tomohiro Sakamoto Tadashi Sawamura Predictors of hypoxemia in type-B acute aortic syndrome: a retrospective study
description	Abstract Acute aortic syndrome (AAS) can be life-threatening owing to a variety of complications, and it is managed in the intensive care unit (ICU). Although Stanford type-B AAS may involve hypoxemia, its predictors are not yet clearly understood. We studied clinical factors and imaging parameters for predicting hypoxemia after the onset of type-B AAS. We retrospectively analyzed patients diagnosed with type-B AAS in our hospital between January 2012 and April 2020. We defined hypoxemia as PaO2/FiO2 ≤ 200 within 7 days after AAS onset and used logistic regression analysis to evaluate prognostic factors for hypoxemia. We analyzed 224 consecutive patients (140 males, mean age 70 ± 14 years) from a total cohort of 267 patients. Among these, 53 (23.7%) had hypoxemia. The hypoxemia group had longer ICU and hospital stays compared with the non-hypoxemia group (median 20 vs. 16 days, respectively; p = 0.039 and median 7 vs. 5 days, respectively; p < 0.001). Male sex (odds ratio [OR] 2.87; 95% confidence interval [CI] 1.24–6.63; p = 0.014), obesity (OR 2.36; 95% CI 1.13–4.97; p = 0.023), patent false lumen (OR 2.33; 95% CI 1.09–4.99; p = 0.029), and high D-dimer level (OR 1.01; 95% CI 1.00–1.02; p = 0.047) were independently associated with hypoxemia by multivariate logistic analysis. This study showed a significant difference in duration of ICU and hospital stays between patients with and without hypoxemia. Furthermore, male sex, obesity, patent false lumen, and high D-dimer level may be significantly associated with hypoxemia in patients with type-B AAS.
format	article
author	Yudai Tamura Yuichi Tamura Motoko Kametani Yoshiaki Minami Tomoko Nakayama Daisuke Takagi Takashi Unoki Megumi Yamamuro Akio Kawamura Tomohiro Sakamoto Tadashi Sawamura
author_facet	Yudai Tamura Yuichi Tamura Motoko Kametani Yoshiaki Minami Tomoko Nakayama Daisuke Takagi Takashi Unoki Megumi Yamamuro Akio Kawamura Tomohiro Sakamoto Tadashi Sawamura
author_sort	Yudai Tamura
title	Predictors of hypoxemia in type-B acute aortic syndrome: a retrospective study
title_short	Predictors of hypoxemia in type-B acute aortic syndrome: a retrospective study
title_full	Predictors of hypoxemia in type-B acute aortic syndrome: a retrospective study
title_fullStr	Predictors of hypoxemia in type-B acute aortic syndrome: a retrospective study
title_full_unstemmed	Predictors of hypoxemia in type-B acute aortic syndrome: a retrospective study
title_sort	predictors of hypoxemia in type-b acute aortic syndrome: a retrospective study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fc5949b03acb4da4bd4fef9b99e08af1
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Predictors of hypoxemia in type-B acute aortic syndrome: a retrospective study

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