Association of gene polymorphisms with women urinary incontinence

Aim of study was set to investigate the association of women urinary incontinence (UI) with serotonin receptor HTR2A T102C and beta 3-adrenergic receptor ADRB3 Trp64Arg genes polymorphisms. The study included 110 women with Urge, Stress, and Mixed UI types and the control group – 105 continent women...

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Autores principales:	Aniulis Povilas, Podlipskyte Aurelija, Smalinskiene Alina, Aniuliene Rosita, Jievaltas Mindaugas
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	adrb3 htr2a serotonin receptor 2a gene polymorphism ui Medicine R
Acceso en línea:	https://doaj.org/article/fc5cb8d28574454bbd0c62907090e79b
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id	oai:doaj.org-article:fc5cb8d28574454bbd0c62907090e79b
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spelling	oai:doaj.org-article:fc5cb8d28574454bbd0c62907090e79b2021-12-05T14:10:55ZAssociation of gene polymorphisms with women urinary incontinence2391-546310.1515/med-2021-0332https://doaj.org/article/fc5cb8d28574454bbd0c62907090e79b2021-08-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0332https://doaj.org/toc/2391-5463Aim of study was set to investigate the association of women urinary incontinence (UI) with serotonin receptor HTR2A T102C and beta 3-adrenergic receptor ADRB3 Trp64Arg genes polymorphisms. The study included 110 women with Urge, Stress, and Mixed UI types and the control group – 105 continent women. Both groups have filled in the ICIQ-FLUTS questionnaire and their blood genotyping was performed. Urge UI subgroup was older and had higher body mass index (BMI) in comparison to other UI types and control group. More than half of all women had family history of UI in Stress UI and Mixed UI subgroups. The frequency of HTR2A T102C gene polymorphism’s minor allele C and genotype CC was significantly more expressed in Urge UI subgroup, as compared with control group (C-77.3 vs 58.7%, p = 0.007 and CC-57.6 vs 31.1%, p = 0.015). The ADRB3 Trp64Arg gene polymorphism did not differ between groups. The regression analysis revealed CC genotype (OR = 3.06, 95% CI: 1.11–8.43; p = 0.030) and allele C (OR = 2.53, 95% CI: 1.16–5.53; p = 0.020) were risk factors for development of Urge UI. We conclude that HTR2A T102C gene polymorphism affected the development of Urge UI.Aniulis PovilasPodlipskyte AurelijaSmalinskiene AlinaAniuliene RositaJievaltas MindaugasDe Gruyterarticleadrb3htr2aserotonin receptor 2agene polymorphismuiMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 1190-1197 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adrb3 htr2a serotonin receptor 2a gene polymorphism ui Medicine R
spellingShingle	adrb3 htr2a serotonin receptor 2a gene polymorphism ui Medicine R Aniulis Povilas Podlipskyte Aurelija Smalinskiene Alina Aniuliene Rosita Jievaltas Mindaugas Association of gene polymorphisms with women urinary incontinence
description	Aim of study was set to investigate the association of women urinary incontinence (UI) with serotonin receptor HTR2A T102C and beta 3-adrenergic receptor ADRB3 Trp64Arg genes polymorphisms. The study included 110 women with Urge, Stress, and Mixed UI types and the control group – 105 continent women. Both groups have filled in the ICIQ-FLUTS questionnaire and their blood genotyping was performed. Urge UI subgroup was older and had higher body mass index (BMI) in comparison to other UI types and control group. More than half of all women had family history of UI in Stress UI and Mixed UI subgroups. The frequency of HTR2A T102C gene polymorphism’s minor allele C and genotype CC was significantly more expressed in Urge UI subgroup, as compared with control group (C-77.3 vs 58.7%, p = 0.007 and CC-57.6 vs 31.1%, p = 0.015). The ADRB3 Trp64Arg gene polymorphism did not differ between groups. The regression analysis revealed CC genotype (OR = 3.06, 95% CI: 1.11–8.43; p = 0.030) and allele C (OR = 2.53, 95% CI: 1.16–5.53; p = 0.020) were risk factors for development of Urge UI. We conclude that HTR2A T102C gene polymorphism affected the development of Urge UI.
format	article
author	Aniulis Povilas Podlipskyte Aurelija Smalinskiene Alina Aniuliene Rosita Jievaltas Mindaugas
author_facet	Aniulis Povilas Podlipskyte Aurelija Smalinskiene Alina Aniuliene Rosita Jievaltas Mindaugas
author_sort	Aniulis Povilas
title	Association of gene polymorphisms with women urinary incontinence
title_short	Association of gene polymorphisms with women urinary incontinence
title_full	Association of gene polymorphisms with women urinary incontinence
title_fullStr	Association of gene polymorphisms with women urinary incontinence
title_full_unstemmed	Association of gene polymorphisms with women urinary incontinence
title_sort	association of gene polymorphisms with women urinary incontinence
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/fc5cb8d28574454bbd0c62907090e79b
work_keys_str_mv	AT aniulispovilas associationofgenepolymorphismswithwomenurinaryincontinence AT podlipskyteaurelija associationofgenepolymorphismswithwomenurinaryincontinence AT smalinskienealina associationofgenepolymorphismswithwomenurinaryincontinence AT aniulienerosita associationofgenepolymorphismswithwomenurinaryincontinence AT jievaltasmindaugas associationofgenepolymorphismswithwomenurinaryincontinence
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Association of gene polymorphisms with women urinary incontinence

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