Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient

Autoimmune hemolytic anemia (AIHA) is characterized by the presence of antibodies directed against self-antigens on red blood cells (RBCs) leading to progressive RBC destruction along with reduced red cell survival. Mixed-type AIHA is characterized by the presence of both warm and cold-autoantibodie...

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Autores principales: Minal Wasnik, Saurabh Lahare, Tushar Jagzape, Ramesh Kumar Chandrakar
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Lenguaje:EN
Publicado: Wolters Kluwer Medknow Publications 2021
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Acceso en línea:https://doaj.org/article/fc61dcad69da41e4ba3531a7edf7b480
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spelling oai:doaj.org-article:fc61dcad69da41e4ba3531a7edf7b4802021-11-12T10:08:28ZBlood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient0973-62471998-356510.4103/ajts.AJTS_74_19https://doaj.org/article/fc61dcad69da41e4ba3531a7edf7b4802021-01-01T00:00:00Zhttp://www.ajts.org/article.asp?issn=0973-6247;year=2021;volume=15;issue=2;spage=247;epage=249;aulast=Wasnikhttps://doaj.org/toc/0973-6247https://doaj.org/toc/1998-3565Autoimmune hemolytic anemia (AIHA) is characterized by the presence of antibodies directed against self-antigens on red blood cells (RBCs) leading to progressive RBC destruction along with reduced red cell survival. Mixed-type AIHA is characterized by the presence of both warm and cold-autoantibodies. These autoantibodies may cause blood-group discrepancy or cross-match incompatibility leading to delay in arranging suitable blood unit for transfusion. The detection of autoantibodies by monospecific-direct antiglobulin test showing positive reaction on immunoglobulin G and C3d and presence of cold-agglutinins leads to the diagnosis. We report a rare case of mixed AIHA in a 15 years female showing severe anemia, blood group discrepancy, and cross-match incompatibility. She received transfusion of least incompatible packed RBCs without any untoward effect.Minal WasnikSaurabh LahareTushar JagzapeRamesh Kumar ChandrakarWolters Kluwer Medknow Publicationsarticleautoantibodiesc3ddirect antiglobulin testdiscrepancymixed autoimmune hemolytic anemiaDiseases of the blood and blood-forming organsRC633-647.5ENAsian Journal of Transfusion Science, Vol 15, Iss 2, Pp 247-249 (2021)
institution DOAJ
collection DOAJ
language EN
topic autoantibodies
c3d
direct antiglobulin test
discrepancy
mixed autoimmune hemolytic anemia
Diseases of the blood and blood-forming organs
RC633-647.5
spellingShingle autoantibodies
c3d
direct antiglobulin test
discrepancy
mixed autoimmune hemolytic anemia
Diseases of the blood and blood-forming organs
RC633-647.5
Minal Wasnik
Saurabh Lahare
Tushar Jagzape
Ramesh Kumar Chandrakar
Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient
description Autoimmune hemolytic anemia (AIHA) is characterized by the presence of antibodies directed against self-antigens on red blood cells (RBCs) leading to progressive RBC destruction along with reduced red cell survival. Mixed-type AIHA is characterized by the presence of both warm and cold-autoantibodies. These autoantibodies may cause blood-group discrepancy or cross-match incompatibility leading to delay in arranging suitable blood unit for transfusion. The detection of autoantibodies by monospecific-direct antiglobulin test showing positive reaction on immunoglobulin G and C3d and presence of cold-agglutinins leads to the diagnosis. We report a rare case of mixed AIHA in a 15 years female showing severe anemia, blood group discrepancy, and cross-match incompatibility. She received transfusion of least incompatible packed RBCs without any untoward effect.
format article
author Minal Wasnik
Saurabh Lahare
Tushar Jagzape
Ramesh Kumar Chandrakar
author_facet Minal Wasnik
Saurabh Lahare
Tushar Jagzape
Ramesh Kumar Chandrakar
author_sort Minal Wasnik
title Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient
title_short Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient
title_full Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient
title_fullStr Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient
title_full_unstemmed Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient
title_sort blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient
publisher Wolters Kluwer Medknow Publications
publishDate 2021
url https://doaj.org/article/fc61dcad69da41e4ba3531a7edf7b480
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AT saurabhlahare bloodgroupdiscrepancyinmixedtypeautoimmunehemolyticanemiainapediatricpatient
AT tusharjagzape bloodgroupdiscrepancyinmixedtypeautoimmunehemolyticanemiainapediatricpatient
AT rameshkumarchandrakar bloodgroupdiscrepancyinmixedtypeautoimmunehemolyticanemiainapediatricpatient
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