Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient

Autoimmune hemolytic anemia (AIHA) is characterized by the presence of antibodies directed against self-antigens on red blood cells (RBCs) leading to progressive RBC destruction along with reduced red cell survival. Mixed-type AIHA is characterized by the presence of both warm and cold-autoantibodie...

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Main Authors:	Minal Wasnik, Saurabh Lahare, Tushar Jagzape, Ramesh Kumar Chandrakar
Format:	article
Language:	EN
Published:	Wolters Kluwer Medknow Publications 2021
Subjects:	autoantibodies c3d direct antiglobulin test discrepancy mixed autoimmune hemolytic anemia Diseases of the blood and blood-forming organs RC633-647.5
Online Access:	https://doaj.org/article/fc61dcad69da41e4ba3531a7edf7b480
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spelling	oai:doaj.org-article:fc61dcad69da41e4ba3531a7edf7b4802021-11-12T10:08:28ZBlood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient0973-62471998-356510.4103/ajts.AJTS_74_19https://doaj.org/article/fc61dcad69da41e4ba3531a7edf7b4802021-01-01T00:00:00Zhttp://www.ajts.org/article.asp?issn=0973-6247;year=2021;volume=15;issue=2;spage=247;epage=249;aulast=Wasnikhttps://doaj.org/toc/0973-6247https://doaj.org/toc/1998-3565Autoimmune hemolytic anemia (AIHA) is characterized by the presence of antibodies directed against self-antigens on red blood cells (RBCs) leading to progressive RBC destruction along with reduced red cell survival. Mixed-type AIHA is characterized by the presence of both warm and cold-autoantibodies. These autoantibodies may cause blood-group discrepancy or cross-match incompatibility leading to delay in arranging suitable blood unit for transfusion. The detection of autoantibodies by monospecific-direct antiglobulin test showing positive reaction on immunoglobulin G and C3d and presence of cold-agglutinins leads to the diagnosis. We report a rare case of mixed AIHA in a 15 years female showing severe anemia, blood group discrepancy, and cross-match incompatibility. She received transfusion of least incompatible packed RBCs without any untoward effect.Minal WasnikSaurabh LahareTushar JagzapeRamesh Kumar ChandrakarWolters Kluwer Medknow Publicationsarticleautoantibodiesc3ddirect antiglobulin testdiscrepancymixed autoimmune hemolytic anemiaDiseases of the blood and blood-forming organsRC633-647.5ENAsian Journal of Transfusion Science, Vol 15, Iss 2, Pp 247-249 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autoantibodies c3d direct antiglobulin test discrepancy mixed autoimmune hemolytic anemia Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	autoantibodies c3d direct antiglobulin test discrepancy mixed autoimmune hemolytic anemia Diseases of the blood and blood-forming organs RC633-647.5 Minal Wasnik Saurabh Lahare Tushar Jagzape Ramesh Kumar Chandrakar Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient
description	Autoimmune hemolytic anemia (AIHA) is characterized by the presence of antibodies directed against self-antigens on red blood cells (RBCs) leading to progressive RBC destruction along with reduced red cell survival. Mixed-type AIHA is characterized by the presence of both warm and cold-autoantibodies. These autoantibodies may cause blood-group discrepancy or cross-match incompatibility leading to delay in arranging suitable blood unit for transfusion. The detection of autoantibodies by monospecific-direct antiglobulin test showing positive reaction on immunoglobulin G and C3d and presence of cold-agglutinins leads to the diagnosis. We report a rare case of mixed AIHA in a 15 years female showing severe anemia, blood group discrepancy, and cross-match incompatibility. She received transfusion of least incompatible packed RBCs without any untoward effect.
format	article
author	Minal Wasnik Saurabh Lahare Tushar Jagzape Ramesh Kumar Chandrakar
author_facet	Minal Wasnik Saurabh Lahare Tushar Jagzape Ramesh Kumar Chandrakar
author_sort	Minal Wasnik
title	Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient
title_short	Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient
title_full	Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient
title_fullStr	Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient
title_full_unstemmed	Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient
title_sort	blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/fc61dcad69da41e4ba3531a7edf7b480
work_keys_str_mv	AT minalwasnik bloodgroupdiscrepancyinmixedtypeautoimmunehemolyticanemiainapediatricpatient AT saurabhlahare bloodgroupdiscrepancyinmixedtypeautoimmunehemolyticanemiainapediatricpatient AT tusharjagzape bloodgroupdiscrepancyinmixedtypeautoimmunehemolyticanemiainapediatricpatient AT rameshkumarchandrakar bloodgroupdiscrepancyinmixedtypeautoimmunehemolyticanemiainapediatricpatient
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Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient

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