Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms

Abstract Many efforts have been devoted to investigating the effect of the interaction between the serotonin transporter gene (5-HTTLPR) and environment (G × E) on depression, but they yield mixed results. The inconsistency has suggested that G × E effects may be more complex than originally concept...

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Autores principales:	Xiaonan Lin, Yanmiao Cao, Linqin Ji, Wenxin Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fc66a641194a4de7973eb721fd29910b
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spelling	oai:doaj.org-article:fc66a641194a4de7973eb721fd29910b2021-12-02T16:17:28ZInhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms10.1038/s41598-021-94267-52045-2322https://doaj.org/article/fc66a641194a4de7973eb721fd29910b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94267-5https://doaj.org/toc/2045-2322Abstract Many efforts have been devoted to investigating the effect of the interaction between the serotonin transporter gene (5-HTTLPR) and environment (G × E) on depression, but they yield mixed results. The inconsistency has suggested that G × E effects may be more complex than originally conceptualized, and further study is warranted. This study explored the association among 5-HTTLPR, peer victimization and depressive symptoms and the underlying mediating role of inhibitory control in this association. A total of 871 Chinese Han adolescents (M age = 15.32 years, 50.3% girls) participated and provided saliva samples from which the 5-HTTLPR was genotyped. This study found that 5-HTTLPR interacted with peer victimization in predicting depressive symptoms. Adolescents carrying L allele reported more depressive symptoms than SS carriers when exposed to higher level of peer victimization. Furthermore, adolescents’ inhibitory control deficits mediated the association between 5-HTTLPR × peer victimization and depressive symptoms. These findings suggested that one pathway in which G × E may confer vulnerability to depressive symptoms is through disruptions to adolescents’ inhibitory control system.Xiaonan LinYanmiao CaoLinqin JiWenxin ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaonan Lin Yanmiao Cao Linqin Ji Wenxin Zhang Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms
description	Abstract Many efforts have been devoted to investigating the effect of the interaction between the serotonin transporter gene (5-HTTLPR) and environment (G × E) on depression, but they yield mixed results. The inconsistency has suggested that G × E effects may be more complex than originally conceptualized, and further study is warranted. This study explored the association among 5-HTTLPR, peer victimization and depressive symptoms and the underlying mediating role of inhibitory control in this association. A total of 871 Chinese Han adolescents (M age = 15.32 years, 50.3% girls) participated and provided saliva samples from which the 5-HTTLPR was genotyped. This study found that 5-HTTLPR interacted with peer victimization in predicting depressive symptoms. Adolescents carrying L allele reported more depressive symptoms than SS carriers when exposed to higher level of peer victimization. Furthermore, adolescents’ inhibitory control deficits mediated the association between 5-HTTLPR × peer victimization and depressive symptoms. These findings suggested that one pathway in which G × E may confer vulnerability to depressive symptoms is through disruptions to adolescents’ inhibitory control system.
format	article
author	Xiaonan Lin Yanmiao Cao Linqin Ji Wenxin Zhang
author_facet	Xiaonan Lin Yanmiao Cao Linqin Ji Wenxin Zhang
author_sort	Xiaonan Lin
title	Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms
title_short	Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms
title_full	Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms
title_fullStr	Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms
title_full_unstemmed	Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms
title_sort	inhibitory control mediates the interaction between serotonin transporter gene (5-httlpr) and peer victimization on adolescent depressive symptoms
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fc66a641194a4de7973eb721fd29910b
work_keys_str_mv	AT xiaonanlin inhibitorycontrolmediatestheinteractionbetweenserotonintransportergene5httlprandpeervictimizationonadolescentdepressivesymptoms AT yanmiaocao inhibitorycontrolmediatestheinteractionbetweenserotonintransportergene5httlprandpeervictimizationonadolescentdepressivesymptoms AT linqinji inhibitorycontrolmediatestheinteractionbetweenserotonintransportergene5httlprandpeervictimizationonadolescentdepressivesymptoms AT wenxinzhang inhibitorycontrolmediatestheinteractionbetweenserotonintransportergene5httlprandpeervictimizationonadolescentdepressivesymptoms
_version_	1718384270004715520

Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms

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