The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies

Abstract As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the sarcoplasmic reticulum (SR) following muscle contraction. SERCA function is closely associated with muscle health and fu...

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Autores principales:	Hongyang Xu, Holly Van Remmen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Skeletal muscle SERCA Calcium homeostasis Aging Neuromuscular disorder Oxidative stress Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/fc66fbb1f57c48fe992a1dcc2f39124d
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spelling	oai:doaj.org-article:fc66fbb1f57c48fe992a1dcc2f39124d2021-11-14T12:07:39ZThe SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies10.1186/s13395-021-00280-72044-5040https://doaj.org/article/fc66fbb1f57c48fe992a1dcc2f39124d2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13395-021-00280-7https://doaj.org/toc/2044-5040Abstract As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the sarcoplasmic reticulum (SR) following muscle contraction. SERCA function is closely associated with muscle health and function, and SERCA activity is susceptible to muscle pathogenesis. For example, it has been well reported that pathological conditions associated with aging, neurodegeneration, and muscular dystrophy (MD) significantly depress SERCA function with the potential to impair intracellular calcium homeostasis and further contribute to muscle atrophy and weakness. As a result, targeting SERCA activity has attracted attention as a therapeutical method for the treatment of muscle pathologies. The interventions include activation of SERCA activity and genetic overexpression of SERCA. This review will focus on SERCA function and regulation mechanisms and describe how those mechanisms are affected under muscle pathological conditions including elevated oxidative stress induced by aging, muscle disease, or neuromuscular disorders. We also discuss the current progress and therapeutic approaches to targeting SERCA in vivo.Hongyang XuHolly Van RemmenBMCarticleSkeletal muscleSERCACalcium homeostasisAgingNeuromuscular disorderOxidative stressDiseases of the musculoskeletal systemRC925-935ENSkeletal Muscle, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Skeletal muscle SERCA Calcium homeostasis Aging Neuromuscular disorder Oxidative stress Diseases of the musculoskeletal system RC925-935
spellingShingle	Skeletal muscle SERCA Calcium homeostasis Aging Neuromuscular disorder Oxidative stress Diseases of the musculoskeletal system RC925-935 Hongyang Xu Holly Van Remmen The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies
description	Abstract As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the sarcoplasmic reticulum (SR) following muscle contraction. SERCA function is closely associated with muscle health and function, and SERCA activity is susceptible to muscle pathogenesis. For example, it has been well reported that pathological conditions associated with aging, neurodegeneration, and muscular dystrophy (MD) significantly depress SERCA function with the potential to impair intracellular calcium homeostasis and further contribute to muscle atrophy and weakness. As a result, targeting SERCA activity has attracted attention as a therapeutical method for the treatment of muscle pathologies. The interventions include activation of SERCA activity and genetic overexpression of SERCA. This review will focus on SERCA function and regulation mechanisms and describe how those mechanisms are affected under muscle pathological conditions including elevated oxidative stress induced by aging, muscle disease, or neuromuscular disorders. We also discuss the current progress and therapeutic approaches to targeting SERCA in vivo.
format	article
author	Hongyang Xu Holly Van Remmen
author_facet	Hongyang Xu Holly Van Remmen
author_sort	Hongyang Xu
title	The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies
title_short	The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies
title_full	The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies
title_fullStr	The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies
title_full_unstemmed	The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies
title_sort	sarcoendoplasmic reticulum calcium atpase (serca) pump: a potential target for intervention in aging and skeletal muscle pathologies
publisher	BMC
publishDate	2021
url	https://doaj.org/article/fc66fbb1f57c48fe992a1dcc2f39124d
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The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies

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