Determination of arsenic and lead in single hair strands by laser ablation inductively coupled plasma mass spectrometry

Abstract The purpose of this study was to develop matrix-matched hair standards and a LA-ICP-MS technique for determination of the As and Pb in a single human hair using single spot scan mode. These results could subsequently be used to infer when the element entered the body. This study was conduct...

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Autores principales:	Ruxin Luo, Xiaohong Su, Weicong Xu, Sujing Zhang, Xianyi Zhuo, Dong Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fc698dfe09a94b43a88b73d179afaec5
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spelling	oai:doaj.org-article:fc698dfe09a94b43a88b73d179afaec52021-12-02T12:30:36ZDetermination of arsenic and lead in single hair strands by laser ablation inductively coupled plasma mass spectrometry10.1038/s41598-017-03660-62045-2322https://doaj.org/article/fc698dfe09a94b43a88b73d179afaec52017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03660-6https://doaj.org/toc/2045-2322Abstract The purpose of this study was to develop matrix-matched hair standards and a LA-ICP-MS technique for determination of the As and Pb in a single human hair using single spot scan mode. These results could subsequently be used to infer when the element entered the body. This study was conducted in two parts. First, a method was developed and validated for the elemental analysis of hair by LA-ICP-MS. A calibration strategy in LA-ICP-MS was developed using prepared matrix-matched laboratory hair standards doped with analytes of interest at a defined concentration. The use of hair strand standards enables calibration curves to be obtained by plotting the analyte ion (M+) intensity normalized to34S+(the ratio M+/34S+) as a function of the concentration determined by ICP-MS of the acidic digests. The linear correlation coefficients (R2) of the calibration curves for the analytes As and Pb were typically between 0.9970 and 0.9998, respectively. Second, an actual hair was measured using the developed method. The spatial distribution of As along the hair was observed in a hair sample from a leukaemia patient treated with arsenic trioxide (As2O3). The actual and estimated times over which the drug entered the body were compared and discussed.Ruxin LuoXiaohong SuWeicong XuSujing ZhangXianyi ZhuoDong MaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ruxin Luo Xiaohong Su Weicong Xu Sujing Zhang Xianyi Zhuo Dong Ma Determination of arsenic and lead in single hair strands by laser ablation inductively coupled plasma mass spectrometry
description	Abstract The purpose of this study was to develop matrix-matched hair standards and a LA-ICP-MS technique for determination of the As and Pb in a single human hair using single spot scan mode. These results could subsequently be used to infer when the element entered the body. This study was conducted in two parts. First, a method was developed and validated for the elemental analysis of hair by LA-ICP-MS. A calibration strategy in LA-ICP-MS was developed using prepared matrix-matched laboratory hair standards doped with analytes of interest at a defined concentration. The use of hair strand standards enables calibration curves to be obtained by plotting the analyte ion (M+) intensity normalized to34S+(the ratio M+/34S+) as a function of the concentration determined by ICP-MS of the acidic digests. The linear correlation coefficients (R2) of the calibration curves for the analytes As and Pb were typically between 0.9970 and 0.9998, respectively. Second, an actual hair was measured using the developed method. The spatial distribution of As along the hair was observed in a hair sample from a leukaemia patient treated with arsenic trioxide (As2O3). The actual and estimated times over which the drug entered the body were compared and discussed.
format	article
author	Ruxin Luo Xiaohong Su Weicong Xu Sujing Zhang Xianyi Zhuo Dong Ma
author_facet	Ruxin Luo Xiaohong Su Weicong Xu Sujing Zhang Xianyi Zhuo Dong Ma
author_sort	Ruxin Luo
title	Determination of arsenic and lead in single hair strands by laser ablation inductively coupled plasma mass spectrometry
title_short	Determination of arsenic and lead in single hair strands by laser ablation inductively coupled plasma mass spectrometry
title_full	Determination of arsenic and lead in single hair strands by laser ablation inductively coupled plasma mass spectrometry
title_fullStr	Determination of arsenic and lead in single hair strands by laser ablation inductively coupled plasma mass spectrometry
title_full_unstemmed	Determination of arsenic and lead in single hair strands by laser ablation inductively coupled plasma mass spectrometry
title_sort	determination of arsenic and lead in single hair strands by laser ablation inductively coupled plasma mass spectrometry
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fc698dfe09a94b43a88b73d179afaec5
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Determination of arsenic and lead in single hair strands by laser ablation inductively coupled plasma mass spectrometry

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