Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody

Angiopoietin (Angpt)-Tie receptor 2 (Tie2) regulates vascular stability and is thus a potential therapeutic target in vascular diseases. Here, the authors report a Tie2-agonistic antibody which targets a site distinct from the Angpt 1-binding site and which influences Tie2 clustering and activation...

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Autores principales:	Gyunghee Jo, Jeomil Bae, Ho Jeong Hong, Ah-reum Han, Do-Kyun Kim, Seon Pyo Hong, Jung A Kim, Sangkyu Lee, Gou Young Koh, Ho Min Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fc69bcd280cf4fe0bfa69e52efbb0a96
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spelling	oai:doaj.org-article:fc69bcd280cf4fe0bfa69e52efbb0a962021-11-08T11:06:53ZStructural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody10.1038/s41467-021-26620-12041-1723https://doaj.org/article/fc69bcd280cf4fe0bfa69e52efbb0a962021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26620-1https://doaj.org/toc/2041-1723Angiopoietin (Angpt)-Tie receptor 2 (Tie2) regulates vascular stability and is thus a potential therapeutic target in vascular diseases. Here, the authors report a Tie2-agonistic antibody which targets a site distinct from the Angpt 1-binding site and which influences Tie2 clustering and activation in an Angpt2 inhibition-resistant manner.Gyunghee JoJeomil BaeHo Jeong HongAh-reum HanDo-Kyun KimSeon Pyo HongJung A KimSangkyu LeeGou Young KohHo Min KimNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gyunghee Jo Jeomil Bae Ho Jeong Hong Ah-reum Han Do-Kyun Kim Seon Pyo Hong Jung A Kim Sangkyu Lee Gou Young Koh Ho Min Kim Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody
description	Angiopoietin (Angpt)-Tie receptor 2 (Tie2) regulates vascular stability and is thus a potential therapeutic target in vascular diseases. Here, the authors report a Tie2-agonistic antibody which targets a site distinct from the Angpt 1-binding site and which influences Tie2 clustering and activation in an Angpt2 inhibition-resistant manner.
format	article
author	Gyunghee Jo Jeomil Bae Ho Jeong Hong Ah-reum Han Do-Kyun Kim Seon Pyo Hong Jung A Kim Sangkyu Lee Gou Young Koh Ho Min Kim
author_facet	Gyunghee Jo Jeomil Bae Ho Jeong Hong Ah-reum Han Do-Kyun Kim Seon Pyo Hong Jung A Kim Sangkyu Lee Gou Young Koh Ho Min Kim
author_sort	Gyunghee Jo
title	Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody
title_short	Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody
title_full	Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody
title_fullStr	Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody
title_full_unstemmed	Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody
title_sort	structural insights into the clustering and activation of tie2 receptor mediated by tie2 agonistic antibody
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fc69bcd280cf4fe0bfa69e52efbb0a96
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Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody

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