ANALYSIS OF ANTIOXIDANT PROTECTION STATE IN INFERTILE MEN OF DIFFERENT ETHNIC GROUPS

An important role in the pathogenesis of male infertility belongs activation of free radical oxidation. Intensification lipoperoxide processes occur together with a decrease in antioxidant protection. According to a study of two ethnic groups found that in men of reproductive age with Russian nation...

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Autores principales:	O. A. Vanteyeva, N. A. Kurashova, B. G. Dashiyev
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	infertility men antioxidant protection lipid peroxidation Science Q
Acceso en línea:	https://doaj.org/article/fc6af543f6414de2959e17e3b1010c12
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spelling	oai:doaj.org-article:fc6af543f6414de2959e17e3b1010c122021-11-23T06:14:28ZANALYSIS OF ANTIOXIDANT PROTECTION STATE IN INFERTILE MEN OF DIFFERENT ETHNIC GROUPS2541-94202587-9596https://doaj.org/article/fc6af543f6414de2959e17e3b1010c122013-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1612https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596An important role in the pathogenesis of male infertility belongs activation of free radical oxidation. Intensification lipoperoxide processes occur together with a decrease in antioxidant protection. According to a study of two ethnic groups found that in men of reproductive age with Russian nationality infertility is most pronounced imbalance in the lipid peroxidation antioxidant protection compared to infertile men Buryat nationality. Reducing the concentration offat-soluble antioxidants (retinol, α-tocopherol) in the blood of Russian men with infertility say about the development of oxidative stress. In men, the Buryat nationality decreasing trend of antioxidant defense enzyme, primarily reduced the level of superoxide dismutase. Perhaps the decreased activity of superoxide dismutase in our study is related either to the depletion of its activity, or the inhibition of lipid peroxidation products. The increased level of lipid peroxidation is associated with a reduction in the antioxidant capacity of the system, which is unable to cope with overproduction of reactive oxygen species and, as a result, the processes of oxidative modification of lipids. The materials for biochemical studies were blood serum and red cells. The total antioxidant activity of serum and the content of its components (superoxide dismutase, α-tocopherol, retinol, blood-reduced glutathione, oxidized glutatione) were evaluated by a spectrofluorofotometer "SHIMADZU-1501" (Japan). Statistical analysis was performed by parametric tests. The study was supported by grants of the President of the Council of the Russian Federation (Scientific School 494.2012.7).O. A. VanteyevaN. A. KurashovaB. G. DashiyevScientific Сentre for Family Health and Human Reproduction Problemsarticleinfertilitymenantioxidant protectionlipid peroxidationScienceQRUActa Biomedica Scientifica, Vol 0, Iss 4, Pp 102-105 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	infertility men antioxidant protection lipid peroxidation Science Q
spellingShingle	infertility men antioxidant protection lipid peroxidation Science Q O. A. Vanteyeva N. A. Kurashova B. G. Dashiyev ANALYSIS OF ANTIOXIDANT PROTECTION STATE IN INFERTILE MEN OF DIFFERENT ETHNIC GROUPS
description	An important role in the pathogenesis of male infertility belongs activation of free radical oxidation. Intensification lipoperoxide processes occur together with a decrease in antioxidant protection. According to a study of two ethnic groups found that in men of reproductive age with Russian nationality infertility is most pronounced imbalance in the lipid peroxidation antioxidant protection compared to infertile men Buryat nationality. Reducing the concentration offat-soluble antioxidants (retinol, α-tocopherol) in the blood of Russian men with infertility say about the development of oxidative stress. In men, the Buryat nationality decreasing trend of antioxidant defense enzyme, primarily reduced the level of superoxide dismutase. Perhaps the decreased activity of superoxide dismutase in our study is related either to the depletion of its activity, or the inhibition of lipid peroxidation products. The increased level of lipid peroxidation is associated with a reduction in the antioxidant capacity of the system, which is unable to cope with overproduction of reactive oxygen species and, as a result, the processes of oxidative modification of lipids. The materials for biochemical studies were blood serum and red cells. The total antioxidant activity of serum and the content of its components (superoxide dismutase, α-tocopherol, retinol, blood-reduced glutathione, oxidized glutatione) were evaluated by a spectrofluorofotometer "SHIMADZU-1501" (Japan). Statistical analysis was performed by parametric tests. The study was supported by grants of the President of the Council of the Russian Federation (Scientific School 494.2012.7).
format	article
author	O. A. Vanteyeva N. A. Kurashova B. G. Dashiyev
author_facet	O. A. Vanteyeva N. A. Kurashova B. G. Dashiyev
author_sort	O. A. Vanteyeva
title	ANALYSIS OF ANTIOXIDANT PROTECTION STATE IN INFERTILE MEN OF DIFFERENT ETHNIC GROUPS
title_short	ANALYSIS OF ANTIOXIDANT PROTECTION STATE IN INFERTILE MEN OF DIFFERENT ETHNIC GROUPS
title_full	ANALYSIS OF ANTIOXIDANT PROTECTION STATE IN INFERTILE MEN OF DIFFERENT ETHNIC GROUPS
title_fullStr	ANALYSIS OF ANTIOXIDANT PROTECTION STATE IN INFERTILE MEN OF DIFFERENT ETHNIC GROUPS
title_full_unstemmed	ANALYSIS OF ANTIOXIDANT PROTECTION STATE IN INFERTILE MEN OF DIFFERENT ETHNIC GROUPS
title_sort	analysis of antioxidant protection state in infertile men of different ethnic groups
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/fc6af543f6414de2959e17e3b1010c12
work_keys_str_mv	AT oavanteyeva analysisofantioxidantprotectionstateininfertilemenofdifferentethnicgroups AT nakurashova analysisofantioxidantprotectionstateininfertilemenofdifferentethnicgroups AT bgdashiyev analysisofantioxidantprotectionstateininfertilemenofdifferentethnicgroups
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ANALYSIS OF ANTIOXIDANT PROTECTION STATE IN INFERTILE MEN OF DIFFERENT ETHNIC GROUPS

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