Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum

Experience-dependent plasticity is a key feature of brain synapses for which neuronal N-Methyl-D-Aspartate receptors (NMDARs) play a major role, from developmental circuit refinement to learning and memory. Astrocytes also express NMDARs, although their exact function has remained controversial. Her...

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Autores principales:	Peter H Chipman, Chi Chung Alan Fung, Alejandra Pazo Fernandez, Abhilash Sawant, Angelo Tedoldi, Atsushi Kawai, Sunita Ghimire Gautam, Mizuki Kurosawa, Manabu Abe, Kenji Sakimura, Tomoki Fukai, Yukiko Goda
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	basal synaptic strength hippocampus astrocytes NMDA receptors GluN2C stratum radiatum Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/fc6c9c03fd6442bd9963a5bad97386fc
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spelling	oai:doaj.org-article:fc6c9c03fd6442bd9963a5bad97386fc2021-11-16T11:04:01ZAstrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum10.7554/eLife.708182050-084Xe70818https://doaj.org/article/fc6c9c03fd6442bd9963a5bad97386fc2021-10-01T00:00:00Zhttps://elifesciences.org/articles/70818https://doaj.org/toc/2050-084XExperience-dependent plasticity is a key feature of brain synapses for which neuronal N-Methyl-D-Aspartate receptors (NMDARs) play a major role, from developmental circuit refinement to learning and memory. Astrocytes also express NMDARs, although their exact function has remained controversial. Here, we identify in mouse hippocampus, a circuit function for GluN2C NMDAR, a subtype highly expressed in astrocytes, in layer-specific tuning of synaptic strengths in CA1 pyramidal neurons. Interfering with astrocyte NMDAR or GluN2C NMDAR activity reduces the range of presynaptic strength distribution specifically in the stratum radiatum inputs without an appreciable change in the mean presynaptic strength. Mathematical modeling shows that narrowing of the width of presynaptic release probability distribution compromises the expression of long-term synaptic plasticity. Our findings suggest a novel feedback signaling system that uses astrocyte GluN2C NMDARs to adjust basal synaptic weight distribution of Schaffer collateral inputs, which in turn impacts computations performed by the CA1 pyramidal neuron.Peter H ChipmanChi Chung Alan FungAlejandra Pazo FernandezAbhilash SawantAngelo TedoldiAtsushi KawaiSunita Ghimire GautamMizuki KurosawaManabu AbeKenji SakimuraTomoki FukaiYukiko GodaeLife Sciences Publications Ltdarticlebasal synaptic strengthhippocampusastrocytesNMDA receptorsGluN2Cstratum radiatumMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	basal synaptic strength hippocampus astrocytes NMDA receptors GluN2C stratum radiatum Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	basal synaptic strength hippocampus astrocytes NMDA receptors GluN2C stratum radiatum Medicine R Science Q Biology (General) QH301-705.5 Peter H Chipman Chi Chung Alan Fung Alejandra Pazo Fernandez Abhilash Sawant Angelo Tedoldi Atsushi Kawai Sunita Ghimire Gautam Mizuki Kurosawa Manabu Abe Kenji Sakimura Tomoki Fukai Yukiko Goda Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum
description	Experience-dependent plasticity is a key feature of brain synapses for which neuronal N-Methyl-D-Aspartate receptors (NMDARs) play a major role, from developmental circuit refinement to learning and memory. Astrocytes also express NMDARs, although their exact function has remained controversial. Here, we identify in mouse hippocampus, a circuit function for GluN2C NMDAR, a subtype highly expressed in astrocytes, in layer-specific tuning of synaptic strengths in CA1 pyramidal neurons. Interfering with astrocyte NMDAR or GluN2C NMDAR activity reduces the range of presynaptic strength distribution specifically in the stratum radiatum inputs without an appreciable change in the mean presynaptic strength. Mathematical modeling shows that narrowing of the width of presynaptic release probability distribution compromises the expression of long-term synaptic plasticity. Our findings suggest a novel feedback signaling system that uses astrocyte GluN2C NMDARs to adjust basal synaptic weight distribution of Schaffer collateral inputs, which in turn impacts computations performed by the CA1 pyramidal neuron.
format	article
author	Peter H Chipman Chi Chung Alan Fung Alejandra Pazo Fernandez Abhilash Sawant Angelo Tedoldi Atsushi Kawai Sunita Ghimire Gautam Mizuki Kurosawa Manabu Abe Kenji Sakimura Tomoki Fukai Yukiko Goda
author_facet	Peter H Chipman Chi Chung Alan Fung Alejandra Pazo Fernandez Abhilash Sawant Angelo Tedoldi Atsushi Kawai Sunita Ghimire Gautam Mizuki Kurosawa Manabu Abe Kenji Sakimura Tomoki Fukai Yukiko Goda
author_sort	Peter H Chipman
title	Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum
title_short	Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum
title_full	Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum
title_fullStr	Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum
title_full_unstemmed	Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum
title_sort	astrocyte glun2c nmda receptors control basal synaptic strengths of hippocampal ca1 pyramidal neurons in the stratum radiatum
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/fc6c9c03fd6442bd9963a5bad97386fc
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Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum

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