Up regulation and nuclear translocation of Y-box binding protein 1 (YB-1) is linked to poor prognosis in ERG-negative prostate cancer
Abstract Y-box binding protein 1 (YB-1) is an RNA and DNA binding factor with potential prognostic cancer. To evaluate the clinical impact of YB-1, a tissue microarray with 11,152 prostate cancers was analysed by immunohistochemistry. Cytoplasmic and nuclear staining was separately analysed. Cytopla...
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Nature Portfolio
2017
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oai:doaj.org-article:fc6c9c3ee17247cfaf0650d4d7afc7382021-12-02T12:32:12ZUp regulation and nuclear translocation of Y-box binding protein 1 (YB-1) is linked to poor prognosis in ERG-negative prostate cancer10.1038/s41598-017-02279-x2045-2322https://doaj.org/article/fc6c9c3ee17247cfaf0650d4d7afc7382017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02279-xhttps://doaj.org/toc/2045-2322Abstract Y-box binding protein 1 (YB-1) is an RNA and DNA binding factor with potential prognostic cancer. To evaluate the clinical impact of YB-1, a tissue microarray with 11,152 prostate cancers was analysed by immunohistochemistry. Cytoplasmic and nuclear staining was separately analysed. Cytoplasmic YB-1 was absent or weak in normal epithelium but seen in 86,3% of carcinomas. Cytoplasmic staining was weak, moderate, and strong in 29.6%, 43.7% and 13.0% of tumours and was accompanied by nuclear YB-1 staining in 32.1% of cases. Particularly nuclear staining was strongly linked to poor patient prognosis (p < 0.0001). YB-1 protein was more abundant in ERG positive (95.1%) than in ERG negative cancers (80.4%; p < 0.0001), but any prognostic impact of YB-1 staining was limited to the ERG-negative subset. Similarly, significant associations with pT stage and Gleason grade (p < 0.0001 each) were driven by the ERG negative subset. The significant association of YB-1 protein detection with deletions of PTEN, 5q21 and 6q15 fits well in the protein’s role as an inhibitor of DNA damage dependent cell cycle arrest, a role that is likely to induce genomic instability. In summary, the data show, that the prognostic impact of YB-1 expression is limited to ERG negative prostate cancers.Asmus HeumannÖzge KayaChristoph BurdelskiClaudia Hube-MaggMartina KluthDagmar S. LangRonald SimonBurkhard BeyerImke ThederanGuido SauterJakob R. IzbickiAndreas M. LuebkeAndrea HinschFrank JacobsenCorinna WittmerFranziska BüscheckDoris HöflmayerSarah MinnerMaria Christina TsourlakisThorsten SchlommWaldemar WilczakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
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Medicine R Science Q Asmus Heumann Özge Kaya Christoph Burdelski Claudia Hube-Magg Martina Kluth Dagmar S. Lang Ronald Simon Burkhard Beyer Imke Thederan Guido Sauter Jakob R. Izbicki Andreas M. Luebke Andrea Hinsch Frank Jacobsen Corinna Wittmer Franziska Büscheck Doris Höflmayer Sarah Minner Maria Christina Tsourlakis Thorsten Schlomm Waldemar Wilczak Up regulation and nuclear translocation of Y-box binding protein 1 (YB-1) is linked to poor prognosis in ERG-negative prostate cancer |
| description |
Abstract Y-box binding protein 1 (YB-1) is an RNA and DNA binding factor with potential prognostic cancer. To evaluate the clinical impact of YB-1, a tissue microarray with 11,152 prostate cancers was analysed by immunohistochemistry. Cytoplasmic and nuclear staining was separately analysed. Cytoplasmic YB-1 was absent or weak in normal epithelium but seen in 86,3% of carcinomas. Cytoplasmic staining was weak, moderate, and strong in 29.6%, 43.7% and 13.0% of tumours and was accompanied by nuclear YB-1 staining in 32.1% of cases. Particularly nuclear staining was strongly linked to poor patient prognosis (p < 0.0001). YB-1 protein was more abundant in ERG positive (95.1%) than in ERG negative cancers (80.4%; p < 0.0001), but any prognostic impact of YB-1 staining was limited to the ERG-negative subset. Similarly, significant associations with pT stage and Gleason grade (p < 0.0001 each) were driven by the ERG negative subset. The significant association of YB-1 protein detection with deletions of PTEN, 5q21 and 6q15 fits well in the protein’s role as an inhibitor of DNA damage dependent cell cycle arrest, a role that is likely to induce genomic instability. In summary, the data show, that the prognostic impact of YB-1 expression is limited to ERG negative prostate cancers. |
| format |
article |
| author |
Asmus Heumann Özge Kaya Christoph Burdelski Claudia Hube-Magg Martina Kluth Dagmar S. Lang Ronald Simon Burkhard Beyer Imke Thederan Guido Sauter Jakob R. Izbicki Andreas M. Luebke Andrea Hinsch Frank Jacobsen Corinna Wittmer Franziska Büscheck Doris Höflmayer Sarah Minner Maria Christina Tsourlakis Thorsten Schlomm Waldemar Wilczak |
| author_facet |
Asmus Heumann Özge Kaya Christoph Burdelski Claudia Hube-Magg Martina Kluth Dagmar S. Lang Ronald Simon Burkhard Beyer Imke Thederan Guido Sauter Jakob R. Izbicki Andreas M. Luebke Andrea Hinsch Frank Jacobsen Corinna Wittmer Franziska Büscheck Doris Höflmayer Sarah Minner Maria Christina Tsourlakis Thorsten Schlomm Waldemar Wilczak |
| author_sort |
Asmus Heumann |
| title |
Up regulation and nuclear translocation of Y-box binding protein 1 (YB-1) is linked to poor prognosis in ERG-negative prostate cancer |
| title_short |
Up regulation and nuclear translocation of Y-box binding protein 1 (YB-1) is linked to poor prognosis in ERG-negative prostate cancer |
| title_full |
Up regulation and nuclear translocation of Y-box binding protein 1 (YB-1) is linked to poor prognosis in ERG-negative prostate cancer |
| title_fullStr |
Up regulation and nuclear translocation of Y-box binding protein 1 (YB-1) is linked to poor prognosis in ERG-negative prostate cancer |
| title_full_unstemmed |
Up regulation and nuclear translocation of Y-box binding protein 1 (YB-1) is linked to poor prognosis in ERG-negative prostate cancer |
| title_sort |
up regulation and nuclear translocation of y-box binding protein 1 (yb-1) is linked to poor prognosis in erg-negative prostate cancer |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/fc6c9c3ee17247cfaf0650d4d7afc738 |
| work_keys_str_mv |
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