Serum Total Bilirubin and Risk of Cancer: A Swedish Cohort Study and Meta-Analysis

Bilirubin has strong antioxidant properties that have been hypothesized to be preventive against the development of cancer. Thus, we aimed to investigate the association between serum total bilirubin (STB) and risk of overall and site-specific cancers in the large Swedish Apolipoprotein Mortality Ri...

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Autores principales:	Maria J. Monroy-Iglesias, Charlotte Moss, Kerri Beckmann, Niklas Hammar, Goran Walldius, Cecilia Bosco, Mieke Van Hemelrijck, Aida Santaolalla
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer risk hyperbilirubinemia bilirubin cohort study lung cancer colorectal cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/fc6e6c2c1e754289bbe758ef6352aa69
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id	oai:doaj.org-article:fc6e6c2c1e754289bbe758ef6352aa69
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spelling	oai:doaj.org-article:fc6e6c2c1e754289bbe758ef6352aa692021-11-11T15:34:13ZSerum Total Bilirubin and Risk of Cancer: A Swedish Cohort Study and Meta-Analysis10.3390/cancers132155402072-6694https://doaj.org/article/fc6e6c2c1e754289bbe758ef6352aa692021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5540https://doaj.org/toc/2072-6694Bilirubin has strong antioxidant properties that have been hypothesized to be preventive against the development of cancer. Thus, we aimed to investigate the association between serum total bilirubin (STB) and risk of overall and site-specific cancers in the large Swedish Apolipoprotein Mortality Risk (AMORIS) cohort. We also performed a systematic review and meta-analysis for specific cancer types (colorectal, breast and lung). We found no association between high levels of STB and risk of overall cancer. Regarding site-specific cancer, there was an inverse association between increased STB and lung cancer (Hazard Ratio (HR) for the 4th quartile (Q4) vs. Q1: 0.50; 95%CI: 0.44–0.59) and gynecological cancer (HR for Q4 vs. Q1: 0.86; 95%CI: 0.76–0.99). A positive association was found with melanoma (HR for Q4 vs. Q1: 1.25; 95%CI: 1.06–1.47) and breast cancer (HR for Q4 vs. Q1: 1.13; 95%CI: 1.01–1.25) risk. The meta-analysis showed an inverse association between high levels of STB and risk of lung cancer (Relative risk (RR): 0.69; 95%CI: 0.55–0.86). No associations were seen for colorectal and breast cancer risk. Further studies are required to establish if bilirubin can be used as a biomarker for risk assessment and/or as a novel therapeutic target.Maria J. Monroy-IglesiasCharlotte MossKerri BeckmannNiklas HammarGoran WalldiusCecilia BoscoMieke Van HemelrijckAida SantaolallaMDPI AGarticlecancer riskhyperbilirubinemiabilirubincohort studylung cancercolorectal cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5540, p 5540 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer risk hyperbilirubinemia bilirubin cohort study lung cancer colorectal cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cancer risk hyperbilirubinemia bilirubin cohort study lung cancer colorectal cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Maria J. Monroy-Iglesias Charlotte Moss Kerri Beckmann Niklas Hammar Goran Walldius Cecilia Bosco Mieke Van Hemelrijck Aida Santaolalla Serum Total Bilirubin and Risk of Cancer: A Swedish Cohort Study and Meta-Analysis
description	Bilirubin has strong antioxidant properties that have been hypothesized to be preventive against the development of cancer. Thus, we aimed to investigate the association between serum total bilirubin (STB) and risk of overall and site-specific cancers in the large Swedish Apolipoprotein Mortality Risk (AMORIS) cohort. We also performed a systematic review and meta-analysis for specific cancer types (colorectal, breast and lung). We found no association between high levels of STB and risk of overall cancer. Regarding site-specific cancer, there was an inverse association between increased STB and lung cancer (Hazard Ratio (HR) for the 4th quartile (Q4) vs. Q1: 0.50; 95%CI: 0.44–0.59) and gynecological cancer (HR for Q4 vs. Q1: 0.86; 95%CI: 0.76–0.99). A positive association was found with melanoma (HR for Q4 vs. Q1: 1.25; 95%CI: 1.06–1.47) and breast cancer (HR for Q4 vs. Q1: 1.13; 95%CI: 1.01–1.25) risk. The meta-analysis showed an inverse association between high levels of STB and risk of lung cancer (Relative risk (RR): 0.69; 95%CI: 0.55–0.86). No associations were seen for colorectal and breast cancer risk. Further studies are required to establish if bilirubin can be used as a biomarker for risk assessment and/or as a novel therapeutic target.
format	article
author	Maria J. Monroy-Iglesias Charlotte Moss Kerri Beckmann Niklas Hammar Goran Walldius Cecilia Bosco Mieke Van Hemelrijck Aida Santaolalla
author_facet	Maria J. Monroy-Iglesias Charlotte Moss Kerri Beckmann Niklas Hammar Goran Walldius Cecilia Bosco Mieke Van Hemelrijck Aida Santaolalla
author_sort	Maria J. Monroy-Iglesias
title	Serum Total Bilirubin and Risk of Cancer: A Swedish Cohort Study and Meta-Analysis
title_short	Serum Total Bilirubin and Risk of Cancer: A Swedish Cohort Study and Meta-Analysis
title_full	Serum Total Bilirubin and Risk of Cancer: A Swedish Cohort Study and Meta-Analysis
title_fullStr	Serum Total Bilirubin and Risk of Cancer: A Swedish Cohort Study and Meta-Analysis
title_full_unstemmed	Serum Total Bilirubin and Risk of Cancer: A Swedish Cohort Study and Meta-Analysis
title_sort	serum total bilirubin and risk of cancer: a swedish cohort study and meta-analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fc6e6c2c1e754289bbe758ef6352aa69
work_keys_str_mv	AT mariajmonroyiglesias serumtotalbilirubinandriskofcanceraswedishcohortstudyandmetaanalysis AT charlottemoss serumtotalbilirubinandriskofcanceraswedishcohortstudyandmetaanalysis AT kerribeckmann serumtotalbilirubinandriskofcanceraswedishcohortstudyandmetaanalysis AT niklashammar serumtotalbilirubinandriskofcanceraswedishcohortstudyandmetaanalysis AT goranwalldius serumtotalbilirubinandriskofcanceraswedishcohortstudyandmetaanalysis AT ceciliabosco serumtotalbilirubinandriskofcanceraswedishcohortstudyandmetaanalysis AT miekevanhemelrijck serumtotalbilirubinandriskofcanceraswedishcohortstudyandmetaanalysis AT aidasantaolalla serumtotalbilirubinandriskofcanceraswedishcohortstudyandmetaanalysis
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Serum Total Bilirubin and Risk of Cancer: A Swedish Cohort Study and Meta-Analysis

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