Alpinia officinarum water extract inhibits the atopic dermatitis-like responses in NC/Nga mice by regulation of inflammatory chemokine production

Alpinia officinarum (AO) has been traditionally used in Asia as an herbal medicine to treat inflammatory and internal diseases. However, the therapeutic effect of AO on atopic dermatitis (AD) is unclear. Therefore, we examined whether Alpinia officinarum water extract (AOWex) affects AD in vivo and...

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Autores principales:	Hyun-Kyung Song, Sun Haeng Park, Hye Jin Kim, Seol Jang, Taesoo Kim
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Alpinia officinarum Atopic dermatitis NC/Nga mice HaCaT cells Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/fc6e877964e04e3abe2fd16178b72a48
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spelling	oai:doaj.org-article:fc6e877964e04e3abe2fd16178b72a482021-11-14T04:29:39ZAlpinia officinarum water extract inhibits the atopic dermatitis-like responses in NC/Nga mice by regulation of inflammatory chemokine production0753-332210.1016/j.biopha.2021.112322https://doaj.org/article/fc6e877964e04e3abe2fd16178b72a482021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011069https://doaj.org/toc/0753-3322Alpinia officinarum (AO) has been traditionally used in Asia as an herbal medicine to treat inflammatory and internal diseases. However, the therapeutic effect of AO on atopic dermatitis (AD) is unclear. Therefore, we examined whether Alpinia officinarum water extract (AOWex) affects AD in vivo and in vitro. Oral administration of AOWex to NC/Nga mice with Dermatophagoies farina extract (DfE)-induced AD-like symptoms significantly reduced the severity of clinical dermatitis, epidermal thickness, and mast cell infiltration into the skin and ear tissue. Decreased total serum IgE, macrophage-derived chemokine (MDC), and regulated on activation, normal T-cell expressed and secreted (RANTES) levels were observed in DfE-induced NC/Nga mice in the AOWex-treated group. These effects were confirmed in vitro using HaCaT cells. Treatment with AOWex inhibited the expression of proinflammatory chemokines such as MDC, RANTES, IP-10 and I-TAC in interferon-γ and tumor necrosis factor-α-stimulated HaCaT cells. The anti-inflammatory effects of AOWex were due to its inhibitory action on MAPK phosphorylation (ERK and JNK), NF-κB, and STAT1. Furthermore, galangin, protocatechuic acid, and epicatechin from AOWex were identified as candidate anti-AD compounds. These results suggest that AOWex exerts therapeutic effects against AD by alleviating AD-like skin lesions, suppressing inflammatory mediators, and inhibiting major signaling molecules.Hyun-Kyung SongSun Haeng ParkHye Jin KimSeol JangTaesoo KimElsevierarticleAlpinia officinarumAtopic dermatitisNC/Nga miceHaCaT cellsTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112322- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alpinia officinarum Atopic dermatitis NC/Nga mice HaCaT cells Therapeutics. Pharmacology RM1-950
spellingShingle	Alpinia officinarum Atopic dermatitis NC/Nga mice HaCaT cells Therapeutics. Pharmacology RM1-950 Hyun-Kyung Song Sun Haeng Park Hye Jin Kim Seol Jang Taesoo Kim Alpinia officinarum water extract inhibits the atopic dermatitis-like responses in NC/Nga mice by regulation of inflammatory chemokine production
description	Alpinia officinarum (AO) has been traditionally used in Asia as an herbal medicine to treat inflammatory and internal diseases. However, the therapeutic effect of AO on atopic dermatitis (AD) is unclear. Therefore, we examined whether Alpinia officinarum water extract (AOWex) affects AD in vivo and in vitro. Oral administration of AOWex to NC/Nga mice with Dermatophagoies farina extract (DfE)-induced AD-like symptoms significantly reduced the severity of clinical dermatitis, epidermal thickness, and mast cell infiltration into the skin and ear tissue. Decreased total serum IgE, macrophage-derived chemokine (MDC), and regulated on activation, normal T-cell expressed and secreted (RANTES) levels were observed in DfE-induced NC/Nga mice in the AOWex-treated group. These effects were confirmed in vitro using HaCaT cells. Treatment with AOWex inhibited the expression of proinflammatory chemokines such as MDC, RANTES, IP-10 and I-TAC in interferon-γ and tumor necrosis factor-α-stimulated HaCaT cells. The anti-inflammatory effects of AOWex were due to its inhibitory action on MAPK phosphorylation (ERK and JNK), NF-κB, and STAT1. Furthermore, galangin, protocatechuic acid, and epicatechin from AOWex were identified as candidate anti-AD compounds. These results suggest that AOWex exerts therapeutic effects against AD by alleviating AD-like skin lesions, suppressing inflammatory mediators, and inhibiting major signaling molecules.
format	article
author	Hyun-Kyung Song Sun Haeng Park Hye Jin Kim Seol Jang Taesoo Kim
author_facet	Hyun-Kyung Song Sun Haeng Park Hye Jin Kim Seol Jang Taesoo Kim
author_sort	Hyun-Kyung Song
title	Alpinia officinarum water extract inhibits the atopic dermatitis-like responses in NC/Nga mice by regulation of inflammatory chemokine production
title_short	Alpinia officinarum water extract inhibits the atopic dermatitis-like responses in NC/Nga mice by regulation of inflammatory chemokine production
title_full	Alpinia officinarum water extract inhibits the atopic dermatitis-like responses in NC/Nga mice by regulation of inflammatory chemokine production
title_fullStr	Alpinia officinarum water extract inhibits the atopic dermatitis-like responses in NC/Nga mice by regulation of inflammatory chemokine production
title_full_unstemmed	Alpinia officinarum water extract inhibits the atopic dermatitis-like responses in NC/Nga mice by regulation of inflammatory chemokine production
title_sort	alpinia officinarum water extract inhibits the atopic dermatitis-like responses in nc/nga mice by regulation of inflammatory chemokine production
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/fc6e877964e04e3abe2fd16178b72a48
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_version_	1718430054778667008

Alpinia officinarum water extract inhibits the atopic dermatitis-like responses in NC/Nga mice by regulation of inflammatory chemokine production

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