FREQUENCY OF DRUG INDUCED HYPERGLYCEMIA DURING REMISSION INDUCTION THERAPY IN ADULTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA

Objectives: To determine the frequency of drug induced hyperglycemia during remission induction and its associated risk factors in adult acute lymphoblastic leukemia (ALL) patients. Study Design: Cross sectional study. Place and Duration of Study: Combined Military Hospital, Rawalpindi Pakistan,...

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Autores principales:	Abdul Ali Wajid, Riaz Ahmad, Ahmad, Iftikhar Hussain, Imtenan Sharif, Amjad Khan, Assam Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	age body mass index hyperglycemia Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fc7175a611154fbab453ffa5cdd0d51c
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spelling	oai:doaj.org-article:fc7175a611154fbab453ffa5cdd0d51c2021-12-01T02:49:20ZFREQUENCY OF DRUG INDUCED HYPERGLYCEMIA DURING REMISSION INDUCTION THERAPY IN ADULTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA0030-96482411-8842https://doaj.org/article/fc7175a611154fbab453ffa5cdd0d51c2018-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2221/1926https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objectives: To determine the frequency of drug induced hyperglycemia during remission induction and its associated risk factors in adult acute lymphoblastic leukemia (ALL) patients. Study Design: Cross sectional study. Place and Duration of Study: Combined Military Hospital, Rawalpindi Pakistan, from May 2017 to Nov 2017. Material and Methods: Fifty one adult patients of newly diagnosed ALL were enrolled in the study. Inclusion criteria included, eighteen years or older, treatment naïve. Patients with history of diabetes, on-going treatment or were taking drugs causing hyperglycemia were excluded from the study. Possible risk factors were recorded including age, body mass index (BMI), gender, family history of diabetes, history of hypertension and disease risk stratification for ALL. Patients were started on standard or augmented Berlin-Frankfurt-Münster (BFM) protocol according to risk category. Fasting and random glucose levels were done twice a week during induction chemotherapy. Hyperglycemia was diagnosed when patients experienced blood glucose greater than 126 mg/dL as fasting or greater than 200mg/dL as post prandial. Data were analyzed using SPSS version 23. Results: Eighteen of our fifty one enrolled patients (35.3%) experienced hyperglycemia during induction chemotherapy. There was also significant increase in fasting blood sugar levels from baseline readings after induction chemotherapy (p-value<0.001). Univariate analysis demonstrated significant association between fasting high blood sugar after induction chemotherapy with age (p-value <0.001) and BMI (p-value=0.034). While on multivariate analysis only age (p<0.001) was found to have significant association with hyperglycemia. Conclusion: Hyperglycemia was observed in less than half of our adult ALL patients during induction chemotherapy. Age was a significant risk factor associated with hyperglycemia.Abdul Ali WajidRiaz AhmadAhmad, Iftikhar HussainImtenan SharifAmjad KhanAssam AhmedArmy Medical College Rawalpindiarticleagebody mass indexhyperglycemiaMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 5, Pp 1059-1065 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	age body mass index hyperglycemia Medicine R Medicine (General) R5-920
spellingShingle	age body mass index hyperglycemia Medicine R Medicine (General) R5-920 Abdul Ali Wajid Riaz Ahmad Ahmad, Iftikhar Hussain Imtenan Sharif Amjad Khan Assam Ahmed FREQUENCY OF DRUG INDUCED HYPERGLYCEMIA DURING REMISSION INDUCTION THERAPY IN ADULTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA
description	Objectives: To determine the frequency of drug induced hyperglycemia during remission induction and its associated risk factors in adult acute lymphoblastic leukemia (ALL) patients. Study Design: Cross sectional study. Place and Duration of Study: Combined Military Hospital, Rawalpindi Pakistan, from May 2017 to Nov 2017. Material and Methods: Fifty one adult patients of newly diagnosed ALL were enrolled in the study. Inclusion criteria included, eighteen years or older, treatment naïve. Patients with history of diabetes, on-going treatment or were taking drugs causing hyperglycemia were excluded from the study. Possible risk factors were recorded including age, body mass index (BMI), gender, family history of diabetes, history of hypertension and disease risk stratification for ALL. Patients were started on standard or augmented Berlin-Frankfurt-Münster (BFM) protocol according to risk category. Fasting and random glucose levels were done twice a week during induction chemotherapy. Hyperglycemia was diagnosed when patients experienced blood glucose greater than 126 mg/dL as fasting or greater than 200mg/dL as post prandial. Data were analyzed using SPSS version 23. Results: Eighteen of our fifty one enrolled patients (35.3%) experienced hyperglycemia during induction chemotherapy. There was also significant increase in fasting blood sugar levels from baseline readings after induction chemotherapy (p-value<0.001). Univariate analysis demonstrated significant association between fasting high blood sugar after induction chemotherapy with age (p-value <0.001) and BMI (p-value=0.034). While on multivariate analysis only age (p<0.001) was found to have significant association with hyperglycemia. Conclusion: Hyperglycemia was observed in less than half of our adult ALL patients during induction chemotherapy. Age was a significant risk factor associated with hyperglycemia.
format	article
author	Abdul Ali Wajid Riaz Ahmad Ahmad, Iftikhar Hussain Imtenan Sharif Amjad Khan Assam Ahmed
author_facet	Abdul Ali Wajid Riaz Ahmad Ahmad, Iftikhar Hussain Imtenan Sharif Amjad Khan Assam Ahmed
author_sort	Abdul Ali Wajid
title	FREQUENCY OF DRUG INDUCED HYPERGLYCEMIA DURING REMISSION INDUCTION THERAPY IN ADULTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA
title_short	FREQUENCY OF DRUG INDUCED HYPERGLYCEMIA DURING REMISSION INDUCTION THERAPY IN ADULTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA
title_full	FREQUENCY OF DRUG INDUCED HYPERGLYCEMIA DURING REMISSION INDUCTION THERAPY IN ADULTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA
title_fullStr	FREQUENCY OF DRUG INDUCED HYPERGLYCEMIA DURING REMISSION INDUCTION THERAPY IN ADULTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA
title_full_unstemmed	FREQUENCY OF DRUG INDUCED HYPERGLYCEMIA DURING REMISSION INDUCTION THERAPY IN ADULTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA
title_sort	frequency of drug induced hyperglycemia during remission induction therapy in adults with acute lymphoblastic leukemia
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/fc7175a611154fbab453ffa5cdd0d51c
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FREQUENCY OF DRUG INDUCED HYPERGLYCEMIA DURING REMISSION INDUCTION THERAPY IN ADULTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA

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