ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population.

Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 control...

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Autores principales:	Ho-Chang Kuo, Kuender D Yang, Suh-Hang Hank Juo, Chi-Di Liang, Wei-Chiao Chen, Yu-Shiuan Wang, Chih-Hung Lee, Edward Hsi, Hong-Ren Yu, Peng-Yeong Woon, I-Chun Lin, Chien-Fu Huang, Daw-Yang Hwang, Chiu-Ping Lee, Li-Yan Lin, Wei-Pin Chang, Wei-Chiao Chang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fc74b3bc4fee4901a0adf1ff89b8cd57
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spelling	oai:doaj.org-article:fc74b3bc4fee4901a0adf1ff89b8cd572021-11-18T06:55:46ZITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population.1932-620310.1371/journal.pone.0017370https://doaj.org/article/fc74b3bc4fee4901a0adf1ff89b8cd572011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21533171/?tool=EBIhttps://doaj.org/toc/1932-6203Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) for genotyping ITPKC. In this study, no significant association was noted for the ITPKC polymorphism (rs28493229) between the controls and KD patients, although the CC genotype was overrepresented. We further combined our data with previously published case/control KD studies in the Taiwanese population and performed a meta-analysis. A significant association between rs28493229 and KD was found (Odds Ratio:1.36, 95% Confidence Interval 1.12-1.66). Importantly, a significant association was obtained between rs28493229 and KD patients with aneurysm formation (P = 0.001, under the recessive model). Taken together, our results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population.Ho-Chang KuoKuender D YangSuh-Hang Hank JuoChi-Di LiangWei-Chiao ChenYu-Shiuan WangChih-Hung LeeEdward HsiHong-Ren YuPeng-Yeong WoonI-Chun LinChien-Fu HuangDaw-Yang HwangChiu-Ping LeeLi-Yan LinWei-Pin ChangWei-Chiao ChangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e17370 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ho-Chang Kuo Kuender D Yang Suh-Hang Hank Juo Chi-Di Liang Wei-Chiao Chen Yu-Shiuan Wang Chih-Hung Lee Edward Hsi Hong-Ren Yu Peng-Yeong Woon I-Chun Lin Chien-Fu Huang Daw-Yang Hwang Chiu-Ping Lee Li-Yan Lin Wei-Pin Chang Wei-Chiao Chang ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population.
description	Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) for genotyping ITPKC. In this study, no significant association was noted for the ITPKC polymorphism (rs28493229) between the controls and KD patients, although the CC genotype was overrepresented. We further combined our data with previously published case/control KD studies in the Taiwanese population and performed a meta-analysis. A significant association between rs28493229 and KD was found (Odds Ratio:1.36, 95% Confidence Interval 1.12-1.66). Importantly, a significant association was obtained between rs28493229 and KD patients with aneurysm formation (P = 0.001, under the recessive model). Taken together, our results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population.
format	article
author	Ho-Chang Kuo Kuender D Yang Suh-Hang Hank Juo Chi-Di Liang Wei-Chiao Chen Yu-Shiuan Wang Chih-Hung Lee Edward Hsi Hong-Ren Yu Peng-Yeong Woon I-Chun Lin Chien-Fu Huang Daw-Yang Hwang Chiu-Ping Lee Li-Yan Lin Wei-Pin Chang Wei-Chiao Chang
author_facet	Ho-Chang Kuo Kuender D Yang Suh-Hang Hank Juo Chi-Di Liang Wei-Chiao Chen Yu-Shiuan Wang Chih-Hung Lee Edward Hsi Hong-Ren Yu Peng-Yeong Woon I-Chun Lin Chien-Fu Huang Daw-Yang Hwang Chiu-Ping Lee Li-Yan Lin Wei-Pin Chang Wei-Chiao Chang
author_sort	Ho-Chang Kuo
title	ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population.
title_short	ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population.
title_full	ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population.
title_fullStr	ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population.
title_full_unstemmed	ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population.
title_sort	itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/fc74b3bc4fee4901a0adf1ff89b8cd57
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ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population.

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