Verrucous plane xanthomas secondary to lipoprotein X dyslipidemia in the context of cholestatic fulminant hepatitis: A case report
Cutaneous xanthomas are the result of dermal deposition of lipid, mostly caused by disorders of lipid metabolism. Less commonly, they occur in the setting of cholestatic liver disease, leading to accumulation of lipoprotein X, a rare form of dyslipidemia that does not respond well to conventional tr...
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2021
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oai:doaj.org-article:fc7574c3de97432cb9323c7b16693d2c2021-11-09T23:03:27ZVerrucous plane xanthomas secondary to lipoprotein X dyslipidemia in the context of cholestatic fulminant hepatitis: A case report2050-313X10.1177/2050313X211057937https://doaj.org/article/fc7574c3de97432cb9323c7b16693d2c2021-11-01T00:00:00Zhttps://doi.org/10.1177/2050313X211057937https://doaj.org/toc/2050-313XCutaneous xanthomas are the result of dermal deposition of lipid, mostly caused by disorders of lipid metabolism. Less commonly, they occur in the setting of cholestatic liver disease, leading to accumulation of lipoprotein X, a rare form of dyslipidemia that does not respond well to conventional treatments. We describe an atypical presentation of sudden diffuse xanthomas secondary to lipoprotein X dyslipidemia in the context of cholestatic fulminant hepatitis caused by trimethoprim-sulfamethoxazole hypersensitivity. Histopathology was also atypical and showed an unusual verrucous appearance consisting of overlying epidermal hyperplasia with hyperkeratosis. Our patient had significant improvement, after normalization of her lipid panel under cholestyramine and 13 sessions of apheresis, with topical corticosteroids offering some relief. This rare case shows the importance of recognizing atypical presentations of xanthomas, particularly when they do not respond to conventional dyslipidemia treatments.Julie DangDarosa LimKevin WattersOlivier SimardKarine DoyonMaxime RhéaumeAlexandra MereniukSAGE PublishingarticleMedicine (General)R5-920ENSAGE Open Medical Case Reports, Vol 9 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Medicine (General) R5-920 |
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Medicine (General) R5-920 Julie Dang Darosa Lim Kevin Watters Olivier Simard Karine Doyon Maxime Rhéaume Alexandra Mereniuk Verrucous plane xanthomas secondary to lipoprotein X dyslipidemia in the context of cholestatic fulminant hepatitis: A case report |
| description |
Cutaneous xanthomas are the result of dermal deposition of lipid, mostly caused by disorders of lipid metabolism. Less commonly, they occur in the setting of cholestatic liver disease, leading to accumulation of lipoprotein X, a rare form of dyslipidemia that does not respond well to conventional treatments. We describe an atypical presentation of sudden diffuse xanthomas secondary to lipoprotein X dyslipidemia in the context of cholestatic fulminant hepatitis caused by trimethoprim-sulfamethoxazole hypersensitivity. Histopathology was also atypical and showed an unusual verrucous appearance consisting of overlying epidermal hyperplasia with hyperkeratosis. Our patient had significant improvement, after normalization of her lipid panel under cholestyramine and 13 sessions of apheresis, with topical corticosteroids offering some relief. This rare case shows the importance of recognizing atypical presentations of xanthomas, particularly when they do not respond to conventional dyslipidemia treatments. |
| format |
article |
| author |
Julie Dang Darosa Lim Kevin Watters Olivier Simard Karine Doyon Maxime Rhéaume Alexandra Mereniuk |
| author_facet |
Julie Dang Darosa Lim Kevin Watters Olivier Simard Karine Doyon Maxime Rhéaume Alexandra Mereniuk |
| author_sort |
Julie Dang |
| title |
Verrucous plane xanthomas secondary to lipoprotein X dyslipidemia in the context of cholestatic fulminant hepatitis: A case report |
| title_short |
Verrucous plane xanthomas secondary to lipoprotein X dyslipidemia in the context of cholestatic fulminant hepatitis: A case report |
| title_full |
Verrucous plane xanthomas secondary to lipoprotein X dyslipidemia in the context of cholestatic fulminant hepatitis: A case report |
| title_fullStr |
Verrucous plane xanthomas secondary to lipoprotein X dyslipidemia in the context of cholestatic fulminant hepatitis: A case report |
| title_full_unstemmed |
Verrucous plane xanthomas secondary to lipoprotein X dyslipidemia in the context of cholestatic fulminant hepatitis: A case report |
| title_sort |
verrucous plane xanthomas secondary to lipoprotein x dyslipidemia in the context of cholestatic fulminant hepatitis: a case report |
| publisher |
SAGE Publishing |
| publishDate |
2021 |
| url |
https://doaj.org/article/fc7574c3de97432cb9323c7b16693d2c |
| work_keys_str_mv |
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