A precision medicine approach to sex-based differences in ideal cardiovascular health

Abstract Cardiovascular disease risk factor profiles and health behaviors are known to differ between women and men. Sex-based differences in ideal cardiovascular health were examined in the My Research Legacy study, which collected cardiovascular health and lifestyle data via Life’s Simple 7 survey...

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Autores principales:	Jane A. Leopold, Elliott M. Antman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fc7a7771e8b54b7e8e24bf1e0d7f3af7
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spelling	oai:doaj.org-article:fc7a7771e8b54b7e8e24bf1e0d7f3af72021-12-02T17:57:16ZA precision medicine approach to sex-based differences in ideal cardiovascular health10.1038/s41598-021-93966-32045-2322https://doaj.org/article/fc7a7771e8b54b7e8e24bf1e0d7f3af72021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93966-3https://doaj.org/toc/2045-2322Abstract Cardiovascular disease risk factor profiles and health behaviors are known to differ between women and men. Sex-based differences in ideal cardiovascular health were examined in the My Research Legacy study, which collected cardiovascular health and lifestyle data via Life’s Simple 7 survey and digital health devices. As the study overenrolled women (n = 1251) compared to men (n = 310), we hypothesized that heterogeneity among women would affect comparisons of ideal cardiovascular health. We identified 2 phenogroups of women in our study cohort by cluster analysis. The phenogroups differed significantly across all 7 cardiovascular health and behavior domains (all p < 0.01) with women in phenogroup 1 having a lower Life’s Simple 7 Health Score than those in phenogroup 2 (5.9 ± 1.3 vs. 7.6 ± 1.3, p < 0.01). Compared to men, women in phenogroup 1 had a higher burden of cardiovascular disease risk factors, exercised less, and had lower ideal cardiovascular health scores (p < 0.01). In contrast, women in phenogroup 2 had fewer cardiovascular risk factors but similar exercise habits and higher ideal cardiovascular health scores than men (p < 0.01). These findings suggest that heterogeneity among study participants should be examined when evaluating sex-based differences in ideal cardiovascular health.Jane A. LeopoldElliott M. AntmanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jane A. Leopold Elliott M. Antman A precision medicine approach to sex-based differences in ideal cardiovascular health
description	Abstract Cardiovascular disease risk factor profiles and health behaviors are known to differ between women and men. Sex-based differences in ideal cardiovascular health were examined in the My Research Legacy study, which collected cardiovascular health and lifestyle data via Life’s Simple 7 survey and digital health devices. As the study overenrolled women (n = 1251) compared to men (n = 310), we hypothesized that heterogeneity among women would affect comparisons of ideal cardiovascular health. We identified 2 phenogroups of women in our study cohort by cluster analysis. The phenogroups differed significantly across all 7 cardiovascular health and behavior domains (all p < 0.01) with women in phenogroup 1 having a lower Life’s Simple 7 Health Score than those in phenogroup 2 (5.9 ± 1.3 vs. 7.6 ± 1.3, p < 0.01). Compared to men, women in phenogroup 1 had a higher burden of cardiovascular disease risk factors, exercised less, and had lower ideal cardiovascular health scores (p < 0.01). In contrast, women in phenogroup 2 had fewer cardiovascular risk factors but similar exercise habits and higher ideal cardiovascular health scores than men (p < 0.01). These findings suggest that heterogeneity among study participants should be examined when evaluating sex-based differences in ideal cardiovascular health.
format	article
author	Jane A. Leopold Elliott M. Antman
author_facet	Jane A. Leopold Elliott M. Antman
author_sort	Jane A. Leopold
title	A precision medicine approach to sex-based differences in ideal cardiovascular health
title_short	A precision medicine approach to sex-based differences in ideal cardiovascular health
title_full	A precision medicine approach to sex-based differences in ideal cardiovascular health
title_fullStr	A precision medicine approach to sex-based differences in ideal cardiovascular health
title_full_unstemmed	A precision medicine approach to sex-based differences in ideal cardiovascular health
title_sort	precision medicine approach to sex-based differences in ideal cardiovascular health
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fc7a7771e8b54b7e8e24bf1e0d7f3af7
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A precision medicine approach to sex-based differences in ideal cardiovascular health

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