Identifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations.

Animal studies are very useful in detection of early disease indicators and in unravelling the pathophysiological processes underlying core psychiatric disorder phenotypes. Early indicators are critical for preventive and efficient treatment of progressive psychiatric disorders like anorexia nervosa...

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Autores principales:	Eneda Pjetri, Ria de Haas, Simone de Jong, Cigdem Gelegen, Hugo Oppelaar, Linda A W Verhagen, Marinus J C Eijkemans, Roger A Adan, Berend Olivier, Martien J Kas
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fc7b1e65ba72473bb7f66435da962330
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spelling	oai:doaj.org-article:fc7b1e65ba72473bb7f66435da9623302021-11-18T08:06:51ZIdentifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations.1932-620310.1371/journal.pone.0050453https://doaj.org/article/fc7b1e65ba72473bb7f66435da9623302012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23226287/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Animal studies are very useful in detection of early disease indicators and in unravelling the pathophysiological processes underlying core psychiatric disorder phenotypes. Early indicators are critical for preventive and efficient treatment of progressive psychiatric disorders like anorexia nervosa. Comparable to physical hyperactivity observed in anorexia nervosa patients, in the activity-based anorexia rodent model, mice and rats express paradoxical high voluntary wheel running activity levels when food restricted. Eleven inbred mouse strains and outbred Wistar WU rats were exposed to the activity-based anorexia model in search of identifying susceptibility predictors. Body weight, food intake and wheel running activity levels of each individual mouse and rat were measured. Mouse strains and rats with high wheel running activity levels during food restriction exhibited accelerated body weight loss. Linear mixed models for repeated measures analysis showed that baseline wheel running activity levels preceding the scheduled food restriction phase strongly predicted activity-based anorexia susceptibility (mice: Beta = -0.0158 (±0.003 SE), P<0.0001; rats: Beta = -0.0242 (±0.004 SE), P<0.0001) compared to other baseline parameters. These results suggest that physical activity levels play an important role in activity-based anorexia susceptibility in different rodent species with genetically diverse background. These findings support previous retrospective studies on physical activity levels in anorexia nervosa patients and indicate that pre-morbid physical activity levels could reflect an early indicator for disease severity.Eneda PjetriRia de HaasSimone de JongCigdem GelegenHugo OppelaarLinda A W VerhagenMarinus J C EijkemansRoger A AdanBerend OlivierMartien J KasPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e50453 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eneda Pjetri Ria de Haas Simone de Jong Cigdem Gelegen Hugo Oppelaar Linda A W Verhagen Marinus J C Eijkemans Roger A Adan Berend Olivier Martien J Kas Identifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations.
description	Animal studies are very useful in detection of early disease indicators and in unravelling the pathophysiological processes underlying core psychiatric disorder phenotypes. Early indicators are critical for preventive and efficient treatment of progressive psychiatric disorders like anorexia nervosa. Comparable to physical hyperactivity observed in anorexia nervosa patients, in the activity-based anorexia rodent model, mice and rats express paradoxical high voluntary wheel running activity levels when food restricted. Eleven inbred mouse strains and outbred Wistar WU rats were exposed to the activity-based anorexia model in search of identifying susceptibility predictors. Body weight, food intake and wheel running activity levels of each individual mouse and rat were measured. Mouse strains and rats with high wheel running activity levels during food restriction exhibited accelerated body weight loss. Linear mixed models for repeated measures analysis showed that baseline wheel running activity levels preceding the scheduled food restriction phase strongly predicted activity-based anorexia susceptibility (mice: Beta = -0.0158 (±0.003 SE), P<0.0001; rats: Beta = -0.0242 (±0.004 SE), P<0.0001) compared to other baseline parameters. These results suggest that physical activity levels play an important role in activity-based anorexia susceptibility in different rodent species with genetically diverse background. These findings support previous retrospective studies on physical activity levels in anorexia nervosa patients and indicate that pre-morbid physical activity levels could reflect an early indicator for disease severity.
format	article
author	Eneda Pjetri Ria de Haas Simone de Jong Cigdem Gelegen Hugo Oppelaar Linda A W Verhagen Marinus J C Eijkemans Roger A Adan Berend Olivier Martien J Kas
author_facet	Eneda Pjetri Ria de Haas Simone de Jong Cigdem Gelegen Hugo Oppelaar Linda A W Verhagen Marinus J C Eijkemans Roger A Adan Berend Olivier Martien J Kas
author_sort	Eneda Pjetri
title	Identifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations.
title_short	Identifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations.
title_full	Identifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations.
title_fullStr	Identifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations.
title_full_unstemmed	Identifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations.
title_sort	identifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/fc7b1e65ba72473bb7f66435da962330
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_version_	1718422267328724992

Identifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations.

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