The impact of vitamin D level on serum lipids in type 2 diabetes mellitus

Background: Vitamin D is considered an important regulator of many metabolic processes in the body. Its deficiency was reported to associate with many pathological conditions, with contradicting reports on its role in dyslipidemia. Objectives: To evaluate the role of vitamin D (total and/or free)...

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Autores principales:	Zainab J. Subber, Hashim M. Hashim, Ghassan A. Al-Shamma
Formato:	article
Lenguaje:	EN
Publicado:	College of Medicine, Al-Nahrain University 2021
Materias:	cholesterol ldl-cholesterol serum lipids t2dm vitamin d Biology (General) QH301-705.5 Microbiology QR1-502 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Biotechnology TP248.13-248.65 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/fc7c72fdc65140c4b18d078ad4e0caef
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spelling	oai:doaj.org-article:fc7c72fdc65140c4b18d078ad4e0caef2021-12-05T19:10:43ZThe impact of vitamin D level on serum lipids in type 2 diabetes mellitus10.47419/bjbabs.v2i04.472706-9915https://doaj.org/article/fc7c72fdc65140c4b18d078ad4e0caef2021-12-01T00:00:00Zhttps://bjbabs.org/index.php/bjbabs/article/view/47/45https://doaj.org/toc/2706-9915Background: Vitamin D is considered an important regulator of many metabolic processes in the body. Its deficiency was reported to associate with many pathological conditions, with contradicting reports on its role in dyslipidemia. Objectives: To evaluate the role of vitamin D (total and/or free) in improving dyslipidemia of type 2 diabetes mellitus (T2DM). Methods: Sixty-four patients with T2DM, and 73 apparently healthy normal subjects were enrolled in the study from March to October 2020. Their fasting blood glucose, glycated hemoglobin, HbA1c, and serum lipids (cholesterol, its fractions and triglycerides) were measured in addition to total and free vitamin D. Results: There was a significant negative correlation between total vitamin D and each of cholesterol and LDL-C in the diabetic group. The correlations between serum vitamin D and all other lipid parameters (HDL-C, VLDL-C and triglycerides) were non-significant in the diabetic group, while in the control groups none of serum lipids showed significant correlations with vitamin D. Conclusions: The significant negative association of vitamin D with total cholesterol and LDLC in the diabetics reveals the important action of vitamin D in reducing the atherogenic indices, and consequent reduction in the rate of atherosclerosis and cardiovascular disease or stroke.Zainab J. SubberHashim M. HashimGhassan A. Al-ShammaCollege of Medicine, Al-Nahrain Universityarticlecholesterolldl-cholesterolserum lipidst2dmvitamin dBiology (General)QH301-705.5MicrobiologyQR1-502Diseases of the endocrine glands. Clinical endocrinologyRC648-665BiotechnologyTP248.13-248.65BiochemistryQD415-436ENBaghdad Journal of Biochemistry and Applied Biological Sciences, Vol 2, Iss 04, Pp 230-236 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cholesterol ldl-cholesterol serum lipids t2dm vitamin d Biology (General) QH301-705.5 Microbiology QR1-502 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Biotechnology TP248.13-248.65 Biochemistry QD415-436
spellingShingle	cholesterol ldl-cholesterol serum lipids t2dm vitamin d Biology (General) QH301-705.5 Microbiology QR1-502 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Biotechnology TP248.13-248.65 Biochemistry QD415-436 Zainab J. Subber Hashim M. Hashim Ghassan A. Al-Shamma The impact of vitamin D level on serum lipids in type 2 diabetes mellitus
description	Background: Vitamin D is considered an important regulator of many metabolic processes in the body. Its deficiency was reported to associate with many pathological conditions, with contradicting reports on its role in dyslipidemia. Objectives: To evaluate the role of vitamin D (total and/or free) in improving dyslipidemia of type 2 diabetes mellitus (T2DM). Methods: Sixty-four patients with T2DM, and 73 apparently healthy normal subjects were enrolled in the study from March to October 2020. Their fasting blood glucose, glycated hemoglobin, HbA1c, and serum lipids (cholesterol, its fractions and triglycerides) were measured in addition to total and free vitamin D. Results: There was a significant negative correlation between total vitamin D and each of cholesterol and LDL-C in the diabetic group. The correlations between serum vitamin D and all other lipid parameters (HDL-C, VLDL-C and triglycerides) were non-significant in the diabetic group, while in the control groups none of serum lipids showed significant correlations with vitamin D. Conclusions: The significant negative association of vitamin D with total cholesterol and LDLC in the diabetics reveals the important action of vitamin D in reducing the atherogenic indices, and consequent reduction in the rate of atherosclerosis and cardiovascular disease or stroke.
format	article
author	Zainab J. Subber Hashim M. Hashim Ghassan A. Al-Shamma
author_facet	Zainab J. Subber Hashim M. Hashim Ghassan A. Al-Shamma
author_sort	Zainab J. Subber
title	The impact of vitamin D level on serum lipids in type 2 diabetes mellitus
title_short	The impact of vitamin D level on serum lipids in type 2 diabetes mellitus
title_full	The impact of vitamin D level on serum lipids in type 2 diabetes mellitus
title_fullStr	The impact of vitamin D level on serum lipids in type 2 diabetes mellitus
title_full_unstemmed	The impact of vitamin D level on serum lipids in type 2 diabetes mellitus
title_sort	impact of vitamin d level on serum lipids in type 2 diabetes mellitus
publisher	College of Medicine, Al-Nahrain University
publishDate	2021
url	https://doaj.org/article/fc7c72fdc65140c4b18d078ad4e0caef
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The impact of vitamin D level on serum lipids in type 2 diabetes mellitus

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