The history and geographic distribution of a KCNQ1 atrial fibrillation risk allele
Many rare high-impact variants have been associated with disease, but the origins and functional impact are not always explored. Here, the authors trace the ancestry of a rare high impact atrial fibrillation allele in KCNQ1, and use iPSC-derived cardiomyocytes to characterize the effect of the allel...
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Nature Portfolio
2021
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oai:doaj.org-article:fc7dba9c47974f5aa229e04e2b3a9d142021-11-14T12:35:47ZThe history and geographic distribution of a KCNQ1 atrial fibrillation risk allele10.1038/s41467-021-26741-72041-1723https://doaj.org/article/fc7dba9c47974f5aa229e04e2b3a9d142021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26741-7https://doaj.org/toc/2041-1723Many rare high-impact variants have been associated with disease, but the origins and functional impact are not always explored. Here, the authors trace the ancestry of a rare high impact atrial fibrillation allele in KCNQ1, and use iPSC-derived cardiomyocytes to characterize the effect of the allele.Shannon HateleyAngelica Lopez-IzquierdoChuanchau J. JouScott ChoJoshua G. SchraiberShiya SongColin T. MaguireNatalia TorresMichael RiedelNeil E. BowlesCammon B. ArringtonBrett J. KennedySusan P. EtheridgeShuping LaiChase PribbleLindsay MeyersDerek LundahlJake ByrnesJulie M. GrankaChristopher A. KauffmanGordon LemmonSteven BoydenW. Scott WatkinsMary Anne KarrenStacey KnightJ. Brent MuhlesteinJohn F. CarlquistJeffrey L. AndersonKenneth G. ChahineKhushi U. ShahCatherine A. BallIvor J. BenjaminMark YandellMartin Tristani-FirouziNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Shannon Hateley Angelica Lopez-Izquierdo Chuanchau J. Jou Scott Cho Joshua G. Schraiber Shiya Song Colin T. Maguire Natalia Torres Michael Riedel Neil E. Bowles Cammon B. Arrington Brett J. Kennedy Susan P. Etheridge Shuping Lai Chase Pribble Lindsay Meyers Derek Lundahl Jake Byrnes Julie M. Granka Christopher A. Kauffman Gordon Lemmon Steven Boyden W. Scott Watkins Mary Anne Karren Stacey Knight J. Brent Muhlestein John F. Carlquist Jeffrey L. Anderson Kenneth G. Chahine Khushi U. Shah Catherine A. Ball Ivor J. Benjamin Mark Yandell Martin Tristani-Firouzi The history and geographic distribution of a KCNQ1 atrial fibrillation risk allele |
| description |
Many rare high-impact variants have been associated with disease, but the origins and functional impact are not always explored. Here, the authors trace the ancestry of a rare high impact atrial fibrillation allele in KCNQ1, and use iPSC-derived cardiomyocytes to characterize the effect of the allele. |
| format |
article |
| author |
Shannon Hateley Angelica Lopez-Izquierdo Chuanchau J. Jou Scott Cho Joshua G. Schraiber Shiya Song Colin T. Maguire Natalia Torres Michael Riedel Neil E. Bowles Cammon B. Arrington Brett J. Kennedy Susan P. Etheridge Shuping Lai Chase Pribble Lindsay Meyers Derek Lundahl Jake Byrnes Julie M. Granka Christopher A. Kauffman Gordon Lemmon Steven Boyden W. Scott Watkins Mary Anne Karren Stacey Knight J. Brent Muhlestein John F. Carlquist Jeffrey L. Anderson Kenneth G. Chahine Khushi U. Shah Catherine A. Ball Ivor J. Benjamin Mark Yandell Martin Tristani-Firouzi |
| author_facet |
Shannon Hateley Angelica Lopez-Izquierdo Chuanchau J. Jou Scott Cho Joshua G. Schraiber Shiya Song Colin T. Maguire Natalia Torres Michael Riedel Neil E. Bowles Cammon B. Arrington Brett J. Kennedy Susan P. Etheridge Shuping Lai Chase Pribble Lindsay Meyers Derek Lundahl Jake Byrnes Julie M. Granka Christopher A. Kauffman Gordon Lemmon Steven Boyden W. Scott Watkins Mary Anne Karren Stacey Knight J. Brent Muhlestein John F. Carlquist Jeffrey L. Anderson Kenneth G. Chahine Khushi U. Shah Catherine A. Ball Ivor J. Benjamin Mark Yandell Martin Tristani-Firouzi |
| author_sort |
Shannon Hateley |
| title |
The history and geographic distribution of a KCNQ1 atrial fibrillation risk allele |
| title_short |
The history and geographic distribution of a KCNQ1 atrial fibrillation risk allele |
| title_full |
The history and geographic distribution of a KCNQ1 atrial fibrillation risk allele |
| title_fullStr |
The history and geographic distribution of a KCNQ1 atrial fibrillation risk allele |
| title_full_unstemmed |
The history and geographic distribution of a KCNQ1 atrial fibrillation risk allele |
| title_sort |
history and geographic distribution of a kcnq1 atrial fibrillation risk allele |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/fc7dba9c47974f5aa229e04e2b3a9d14 |
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