Capture of microparticles by bolus flow of red blood cells in capillaries

Abstract Previous studies have concluded that microparticles (MPs) can more effectively approach the microvessel wall than nanoparticles because of margination. In this study, however, we show that MPs are not marginated in capillaries where the vessel diameter is comparable to that of red blood cel...

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Auteurs principaux:	Naoki Takeishi, Yohsuke Imai
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/fc7dded5e988493dbdce0ab0e15aa4e8
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spelling	oai:doaj.org-article:fc7dded5e988493dbdce0ab0e15aa4e82021-12-02T15:05:24ZCapture of microparticles by bolus flow of red blood cells in capillaries10.1038/s41598-017-05924-72045-2322https://doaj.org/article/fc7dded5e988493dbdce0ab0e15aa4e82017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05924-7https://doaj.org/toc/2045-2322Abstract Previous studies have concluded that microparticles (MPs) can more effectively approach the microvessel wall than nanoparticles because of margination. In this study, however, we show that MPs are not marginated in capillaries where the vessel diameter is comparable to that of red blood cells (RBCs). We numerically investigated the behavior of MPs with a diameter of 1 μm in various microvessel sizes, including capillaries. In capillaries, the flow mode of RBCs shifted from multi-file flow to bolus (single-file) flow, and MPs were captured by the bolus flow of the RBCs instead of being marginated. Once MPs were captured, they rarely escaped from the vortex-like flow structures between RBCs. These capture events were enhanced when the hematocrit was decreased, and reduced when the shear rate was increased. Our results suggest that microparticles may be rather inefficient drug carriers when targeting capillaries because of capture events, but nanoparticles, which are more randomly distributed in capillaries, may be more effective carriers.Naoki TakeishiYohsuke ImaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Naoki Takeishi Yohsuke Imai Capture of microparticles by bolus flow of red blood cells in capillaries
description	Abstract Previous studies have concluded that microparticles (MPs) can more effectively approach the microvessel wall than nanoparticles because of margination. In this study, however, we show that MPs are not marginated in capillaries where the vessel diameter is comparable to that of red blood cells (RBCs). We numerically investigated the behavior of MPs with a diameter of 1 μm in various microvessel sizes, including capillaries. In capillaries, the flow mode of RBCs shifted from multi-file flow to bolus (single-file) flow, and MPs were captured by the bolus flow of the RBCs instead of being marginated. Once MPs were captured, they rarely escaped from the vortex-like flow structures between RBCs. These capture events were enhanced when the hematocrit was decreased, and reduced when the shear rate was increased. Our results suggest that microparticles may be rather inefficient drug carriers when targeting capillaries because of capture events, but nanoparticles, which are more randomly distributed in capillaries, may be more effective carriers.
format	article
author	Naoki Takeishi Yohsuke Imai
author_facet	Naoki Takeishi Yohsuke Imai
author_sort	Naoki Takeishi
title	Capture of microparticles by bolus flow of red blood cells in capillaries
title_short	Capture of microparticles by bolus flow of red blood cells in capillaries
title_full	Capture of microparticles by bolus flow of red blood cells in capillaries
title_fullStr	Capture of microparticles by bolus flow of red blood cells in capillaries
title_full_unstemmed	Capture of microparticles by bolus flow of red blood cells in capillaries
title_sort	capture of microparticles by bolus flow of red blood cells in capillaries
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fc7dded5e988493dbdce0ab0e15aa4e8
work_keys_str_mv	AT naokitakeishi captureofmicroparticlesbybolusflowofredbloodcellsincapillaries AT yohsukeimai captureofmicroparticlesbybolusflowofredbloodcellsincapillaries
_version_	1718388869725945856

Capture of microparticles by bolus flow of red blood cells in capillaries

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